Interdisciplinary Study of Two Novel Anticonvulsants in Alcoholism

 描述(申请人提供)：在最近的一项双盲安慰剂对照研究中，我们发现广谱抗惊厥药卓尼沙胺(ZON)对乙醇消耗的影响与托吡酯相当。我们在这里假设，ZON通过其神经保护作用减弱禁欲期间大脑的过度兴奋性，并增强中脑和额叶区域的多巴胺活性，将抵消酒精的影响，这些影响导致控制酒精消费的情绪和奖励过程的调节受损。这将从酒精和情绪词Stroop任务中大脑活动的正常化以及对酒精相关图像的大胆反应的减少中可见一斑。这项研究的结果应该为ZON调节酒精消费的神经行为机制提供一个指示。

 DESCRIPTION (provided by applicant): In a recent double-blind placebo-controlled study we found the broad spectrum anticonvulsant zonisamide (ZON) to have effects on ethanol consumption that are comparable to those of topiramate. We hypothesize here that the administration of ZON, by attenuating the hyperexcitability of the brain during periods of abstinence, through its neuro-protective effects, and its enhancement of dopamine activity in midbrain and frontal regions will counteract the effects of alcohol that lead to impaired regulatio of emotional and reward processes that control the consumption of alcohol. This will be evident by the normalization of brain activity seen in performance of the alcohol and emotional-word Stroop tasks and in a reduction of the BOLD response to alcohol related images. The results of this study should provide an indication of the neurobehavioral mechanisms through which ZON may act to regulate the consumption of alcohol.