Interdisciplinary Study of Two Novel Anticonvulsants in Alcoholism

 描述（由申请人提供）：在最近的一项双盲安慰剂对照研究中，我们发现广谱抗惊厥药唑尼沙胺（ZON）对乙醇消耗量的影响与托吡酯相当。我们在这里假设，ZON的管理，通过减弱过度兴奋的大脑在禁欲期间，通过其神经保护作用，并在中脑和额叶区域的多巴胺活性的增强，将抵消酒精的影响，导致受损的调节情绪和奖励过程，控制酒精的消费。这将是显而易见的，在酒精和情绪词Stroop任务的表现中看到的大脑活动的正常化，以及对酒精相关图像的BOLD反应的减少。这项研究的结果应该提供一个指示的神经行为机制，通过ZON可能会采取行动，以调节酒精的消费。

 DESCRIPTION (provided by applicant): In a recent double-blind placebo-controlled study we found the broad spectrum anticonvulsant zonisamide (ZON) to have effects on ethanol consumption that are comparable to those of topiramate. We hypothesize here that the administration of ZON, by attenuating the hyperexcitability of the brain during periods of abstinence, through its neuro-protective effects, and its enhancement of dopamine activity in midbrain and frontal regions will counteract the effects of alcohol that lead to impaired regulatio of emotional and reward processes that control the consumption of alcohol. This will be evident by the normalization of brain activity seen in performance of the alcohol and emotional-word Stroop tasks and in a reduction of the BOLD response to alcohol related images. The results of this study should provide an indication of the neurobehavioral mechanisms through which ZON may act to regulate the consumption of alcohol.