Community Mobilization and HIV/STI Epidemiology of Female Sex Workers in Mexico

墨西哥女性性工作者的社区动员和艾滋病毒/性传播感染流行病学

• 批准号: 8603112
• 负责人: Lianne A Urada
• 金额: $ 18.76万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8603112
• 关键词: AIDS prevention; Address; Advocacy; Advocate; Affect; Alcohol consumption; Alcohol dependence; Alcohol or Other Drugs use; Applications Grants; Attention; Behavior; Behavioral; Biological; Biological Markers; Border Crossings; Brazil; California; Caribbean region; Cities; Coercion; Cognitive; Communities; Community Workers; Conscious; Cost-Benefit Analysis; Data; Data Analyses; Data Collection; Dependence; Development Plans; Diffuse; Drug usage; Ensure; Epidemiology; Ethics; Evaluation Methodology; Event; Face; Female; Focus Groups; Forcible intercourse; Funding; Future; General Population; Goals; Guidelines; HIV; HIV Infections; HIV risk; HIV/STD; Harm Reduction; Health; Health Services Accessibility; Human Rights; Illicit Drugs; India; Individual; Infection; International; Intervention; Intervention Studies; Interview; Knowledge; Lead; Learning; Literature; Marijuana; Measurement; Measures; Mentored Research Scientist Development Award; Mentors; Methods; Mexico; Modeling; National Institute of Drug Abuse; Nature; Needles; Outcome; Pharmaceutical Preparations; Police; Population; Positioning Attribute; Prevalence; Prevention; Preventive Intervention; Public Health; Publishing; Readability; Recording of previous events; Reporting; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Project Grants; Rights; Risk; Risk Behaviors; Role; Shares syringes; Surveys; Syringes; Testing; Time; Training; United States; Universities; Unsafe Sex; Victimization; Violence; Vulnerable Populations; Woman; Work; World Health Organization; base; career; career development; clinical epidemiology; design; empowerment; experience; follow-up; high risk; improved; injection drug use; interest; parent grant; peer; programs; sex; sex risk; skills; social; solidarity; substance abuse epidemiology; transmission process

DESCRIPTION (provided by applicant): This Mentored Research Scientist Development Award (K01) will enable me to 1) acquire expertise in the research methods of developing structural HIV prevention interventions targeting substance using female sex workers (FSWs); 2) increase knowledge of substance abuse epidemiology, assessment and prevention; 3) obtain additional training in the culturally competent ethical conduct of research involving behavioral and biological HIV/STI data collection, violence measurement, and structural interventions in a new international setting; 4) learn how to design RCTs of interventions and conduct related longitudinal data analyses (GLMM); 5) hone skills needed for a successful academic career studying the intersection of substance use, HIV/STI acquisition, and structural risk and protective factors among high risk populations, including grantsmanship and disseminating scientific research findings nationally and internationally. My career development plan will include a mixture of didactic courses, seminars, hands-on field research experience, and mentored independent studies which will provide me with training in intervention evaluation methodologies, substance use epidemiology, and clinical biomarkers. For example, I will take courses in longitudinal data analyses (e.g. event history and survival, and cost-benefit analyses). I will work with a world-renowned mentoring team and an infrastructure already in place in Mexico, with the goal of applying what I learn to other national contexts as well. I will train in intervention adaptation while simultaneously practicing rigorous RCT evaluation methodologies (Generalized Linear Mixed Modeling (GLMM)) on existing data, with the goal of becoming one of a few structural HIV prevention intervention researchers for FSWs worldwide. My proposed K01 project "Mujeres Unidas" (Women United) will be embedded in the NIDA funded parent grant, "Proyecto Mapa de Salud" (R01DA028692-01, PI: Brouwer), which explores HIV/STI transmission among FSWs and other vulnerable populations along the Mexico/U.S. border. In Tijuana, Mexico, Mujeres Unidas will 1) qualitatively interview FSWs (N=30) and FSW advocates/organizers (N=20) about community mobilization and the role of substance use; 2) adapt measures of community mobilization to the Tijuana context through cognitive testing with FSWs (n=10) to ensure readability and acceptability, and 3) determine the prevalence of community mobilization participation and its association with substance use, HIV/STI prevalence and sexual risk behaviors among FSWs by adding adapted measures to the parent grant's 12- month follow up surveys (N=300 FSWs). Results will generate pilot data for a future R34 grant application to pilot/feasibility test an adapted preventive intervention targeting drug use and HIV infection acquisition.

描述(由申请人提供)：这个有指导的研究科学家发展奖(K01)将使我能够1)获得针对女性性工作者(FSWs)开发针对药物的结构性艾滋病毒预防干预措施的研究方法方面的专业知识；2)增加药物滥用流行病学、评估和预防的知识；3)在新的国际环境下获得关于研究的文化能力的额外培训，包括行为和生物艾滋病毒/性传播感染数据收集、暴力测量和结构性干预措施；4)学习如何设计干预措施的随机对照试验并进行相关的纵向数据分析(GLMM)；5)磨练成功的学术生涯所需的技能，研究药物使用、艾滋病毒/性传播感染的获取以及高危人群中的结构性风险和保护因素之间的交集，包括在国内和国际上开展研究和传播科学研究成果。我的职业发展计划将包括授课课程、研讨会、实践现场研究经验和有指导的独立研究，这些研究将为我提供干预评估方法、物质使用流行病学和临床生物标记物方面的培训。例如，我将选修纵向数据分析课程(例如，事件历史和存活率，以及成本效益分析)。我将与一个世界知名的指导团队和墨西哥已经到位的基础设施合作，目标是将我所学到的东西也应用到其他国家的背景中。我将在干预适应方面进行培训，同时在现有数据上实践严格的随机对照试验评估方法(广义线性混合建模(GLMM))，目标是成为全球为数不多的针对暗娼的结构性艾滋病毒预防干预研究人员之一。我提议的K01项目“团结的妇女”将被嵌入到NIDA资助的父母资助的项目“项目马帕德·萨卢德”(R01DA028692-01，PI：Brouwer)中，该项目探索艾滋病/性传播疾病在墨西哥和美国边境的FSWs和其他弱势群体中的传播。在墨西哥提华纳，MuJeres Unidas将1)就社区动员和物质使用的作用定性地采访FSWs(N=30)和FSWs的倡导者/组织者(N=20)；2)通过对FSWs(n=10)进行认知测试，使社区动员措施适应提华纳的情况，以确保可读性和可接受性；3)通过在父母赠款的12个月后续调查(N=300 FSWs)中增加适当的措施，确定FSWs中社区动员参与的流行率及其与药物使用、艾滋病毒/性传播感染流行率和性危险行为的关系。结果将为未来的R34赠款申请产生试点数据，以试点/可行性测试针对药物使用和艾滋病毒感染获得的适应预防干预措施。