Brain Damage and Exercise Neurorestoration After Repeated Binge Alcohol Exposure
反复酗酒后的脑损伤和运动神经恢复
基本信息
- 批准号:8731787
- 负责人:
- 金额:$ 17.34万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-09-10 至 2016-08-31
- 项目状态:已结题
- 来源:
- 关键词:AbstinenceAddressAdultAffectAlcohol consumptionAlcohol dependenceAlcohol-Induced DisordersAlcoholsAnimal ModelAnimalsAreaAstrocytesBrainBrain InjuriesCell CountCell DeathCellsCognitionCognitiveCognitive deficitsConsumptionDataDementiaDevelopmentEmotionalEnsureEpidemiologyExerciseExposure toFemaleFunctional disorderGenerationsHealthHeavy DrinkingHippocampus (Brain)Impaired cognitionImpairmentInjuryLifeMediatingMissionModelingNerve DegenerationNeurodegenerative DisordersNeurogliaNeuronsOligodendrogliaPatternPrefrontal CortexProcessPublic HealthRattusRecoveryRecovery of FunctionRiskSeveritiesShort-Term MemoryStem cellsStructureTestingTimeUnited StatesWithdrawalaging brainalcohol exposurealcohol use disorderbinge drinkerbinge drinkingbrain behaviorbrain repairdentate gyruseffective therapyfrontal lobefunctional disabilitygliogenesisgranule cellimprovedneurogenesisneurorestorationpartial recoveryprogenitorregenerativerelating to nervous systemrepairedresearch studyrestorationsedentarytreatment programway findingyoung adult
项目摘要
DESCRIPTION (provided by applicant): The objective of this proposal is to evaluate cumulative brain damage and the potential for exercise neurorestoration in a rat model of an alcohol use disorder (AUD), which conforms to NIAAA's mission to improve the treatment of AUDs. Binge alcohol consumption impairs cognition and damages the brain by promoting cell death and inhibiting neurogenesis. Exercise, on the other hand, enhances brain health and function. Because binge drinking is a pattern of consumption, and thus by definition occurs repeatedly, this proposal will determine whether exercise can restore the brain after repeated binge episodes. Evidence suggests that repair attempts occur in the brain after a single binge. It is possible that if successive binges occur during ongoing repair attempts, they will not only independently cause damage, but also suppress efforts to repair damage caused by the previous binge. Our proposed experiments will test this hypothesis by timing subsequent binges to overlap with brain repair attempts, and quantify cumulative damage and resulting cognitive impairment. We will assess cognitive impairment both early and chronically after the last binge. We hypothesize that cognitive dysfunction will become more severe and more lasting with increasing binge episodes. Finally, we will determine whether post-binge exercise can ameliorate cumulative brain damage and cognitive dysfunction by allowing abstinent rats to exercise post-binge. We have previously shown that exercise is neuroprotective against damage incurred by a subsequent binge episode. We hypothesize that post-binge exercise will enhance natural brain repair processes during abstinence, resulting in reduced cognitive dysfunction compared to sedentary binge-exposed animals. This application is relevant to public health because it will determine whether exercise could be a useful component of treatment programs aimed at reducing the negative neural and functional consequences of binge alcohol consumption.
描述(由申请方提供):本提案的目的是评价酒精使用障碍(AUD)大鼠模型中的累积脑损伤和运动神经恢复潜力,这符合NIAAA改善AUD治疗的使命。酗酒会损害认知能力,并通过促进细胞死亡和抑制神经发生来损害大脑。另一方面,锻炼可以增强大脑的健康和功能。由于暴饮暴食是一种消费模式,因此根据定义会反复发生,因此该提案将确定运动是否可以在反复暴饮暴食后恢复大脑。有证据表明,在一次狂欢后,大脑中会发生修复尝试。有可能的是,如果连续的狂欢发生在正在进行的修复尝试期间,它们不仅会独立地造成损害,而且会抑制修复先前狂欢造成的损害的努力。我们提出的实验将测试这一假设的时间随后狂欢重叠与大脑修复的尝试,并量化累积的损害和由此产生的认知障碍。我们将在最后一次狂欢后评估早期和长期的认知障碍。我们推测,认知功能障碍将变得更加严重,更持久的增加狂欢发作。最后,我们将通过让戒断大鼠在狂欢后运动来确定狂欢后运动是否可以改善累积的脑损伤和认知功能障碍。我们先前已经证明,运动对随后的狂欢事件造成的损害具有神经保护作用。我们假设,与久坐不动的暴饮暴食动物相比,暴饮暴食后运动将增强禁欲期间的自然大脑修复过程,从而减少认知功能障碍。这项应用与公共卫生有关,因为它将确定运动是否可以成为旨在减少酗酒对神经和功能的负面影响的治疗计划的有用组成部分。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Investigation of Sex Differences in the Microglial Response to Binge Ethanol and Exercise.
- DOI:10.3390/brainsci7100139
- 发表时间:2017-10-24
- 期刊:
- 影响因子:3.3
- 作者:Barton EA;Baker C;Leasure JL
- 通讯作者:Leasure JL
Can the Brain Benefits of Exercise Be Enhanced Without Additional Exercise?
不额外运动就能增强运动对大脑的益处吗?
- DOI:10.29245/2572.942x/2016/2.1027
- 发表时间:2016
- 期刊:
- 影响因子:0
- 作者:LeighLeasure,J;West,Rebecca
- 通讯作者:West,Rebecca
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J. Leigh Leasure其他文献
J. Leigh Leasure的其他文献
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{{ truncateString('J. Leigh Leasure', 18)}}的其他基金
Brain Damage and Exercise Neurorestoration After Repeated Binge Alcohol Exposure
反复酗酒后的脑损伤和运动神经恢复
- 批准号:
8285901 - 财政年份:2013
- 资助金额:
$ 17.34万 - 项目类别:
Combination Therapy for Chronic Stroke-Induced Impairment
慢性中风引起的损伤的联合治疗
- 批准号:
7315114 - 财政年份:2007
- 资助金额:
$ 17.34万 - 项目类别:
Combination Therapy for Chronic Stroke-Induced Impairment
慢性中风引起的损伤的联合治疗
- 批准号:
7485800 - 财政年份:2007
- 资助金额:
$ 17.34万 - 项目类别:
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