Vermont Genetics Network-Vermont INBRE

佛蒙特州遗传学网络-佛蒙特州 INBRE

• 批准号: 8676546
• 负责人: JUDITH L VAN HOUTEN
• 金额: $ 307.38万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8676546
• 关键词: Attitude; Award; Bioinformatics; Biomedical Research; Development; Education; Education and Outreach; Educational Curriculum; Evaluation; Extramural Activities; Faculty; Funding; Genetic; High School Student; Institution; Lead; Logic; Longitudinal Studies; Modeling; Occupations; Output; Progress Reports; Proteomics; Protocols documentation; Publishing; Research; Research Infrastructure; Research Personnel; Resource Sharing; Resources; Science; Services; Students; Time; Universities; Vermont; career; college; community college; graduate student; improved; interest; outreach; outreach program; programs; research facility; science education; tool

The Vermont IDeA Network for Biomedical Research Excellence (INBRE) is the Vermont Genetics Network (VGN). We build biomedical research capacity throughout the state by promoting faculty and Student research at our Baccalaureate Partner Institutions (BPIs) with research awards and renovations; reaching out to BPIs and other colleges with delivery of curriculum modules for students to have hands-on opportunities to carry out realistic research protocols and use VGN's facilities; developing Microarray and Proteomics facilities that serve the entire network; providing Bioinformatics services; supporting new faculty and graduate students at the University of Vermont (UVM). Our assessments show our faculty at both BPIs and UVM are publishing, applying for extramural funding and becoming competitive for this funding. Our facilities support the entire network. We use the theme of Genetics because it allows for inclusion of many kinds of biomedical research at UVM and BPIs and promotes a broad network. VGN has four current specific aims: 1. Build a Culture of Research at the BPIs; 2. Establish an Outreach Core for institutions outside our network; 3. Strengthen the Research Capacity and Critical Mass of Genetics Biomedical Researchers at UVM; 4. Assess the progress through longitudinal studies. Over four years, we have made substantial progress toward all of these aims. VGN has become a leader in promoting research resources and building consortia among the Bioinformatics Cores. VGN has changed the attitude in colleges toward UVM that now is considered a welcoming place for college faculty and student research. In this application for renewal of funding for VGN, we have five Specific Aims: 1. Expand the network to include more BPIs and develop cultures of research at these new and current BPIs. 2. Expand education outreach to more colleges, including the Community College of Vermont (CCV). 3. Focus research capacity building for the state and region on Proteomics and provide state-of-the-art Microarray services. This includes the provision of Bioinformatics services that are critical for the Proteomics and Microarray facilities. 4. Expand our regional and national efforts to share research resources. 5. Assess the progress of VGN through a new set of evaluation tools. New proposed aspects of our application include an expanded workforce development effort through an expanded network of BPIs and inclusion of CCV in our outreach program. We will increase our emphasis on facilities and services in Proteomics, Microarray and Bioinformatics and promote regional and national shahng of research resources. A Logic Model and Output Time line for assessment will be important additions to our evaluation plan.

佛蒙特州IDEA生物医学研究卓越网络（INBRE）是佛蒙特州遗传学网络（VGN）。我们通过促进教师和学生的研究在我们的学士学位合作机构（BPIs）与研究奖励和装修在整个国家建立生物医学研究能力;接触BPIs和其他学院提供课程模块，让学生有动手的机会进行现实的研究协议，并使用VGN的设施;开发微阵列和蛋白质组学设施，服务于整个网络;提供生物信息学服务;支持佛蒙特大学（UVM）的新教师和研究生。我们的评估显示，我们在两个BPI和UVM教师出版，申请校外资助，并成为这项资金的竞争力。我们的设施支持整个网络。我们使用遗传学的主题，因为它允许在UVM和BPIs包含多种生物医学研究，并促进广泛的网络。VGN目前有四个具体目标：1。在BPI建立研究文化; 2。为我们网络之外的机构建立外展核心; 3.加强研究能力和遗传学生物医学研究人员在UVM的临界质量; 4.通过纵向研究评估进展。四年来，我们在实现所有这些目标方面取得了重大进展。VGN已成为促进研究资源和建立生物信息学核心联盟的领导者。VGN改变了大学对UVM的态度，现在UVM被认为是大学教师和学生研究的欢迎场所。 在VGN的资金更新申请中，我们有五个具体目标：1。扩大网络，以包括更多的BPI，并在这些新的和当前的BPI发展研究文化。2.扩大教育推广到更多的大学，包括佛蒙特州社区学院（CCV）。3.专注于蛋白质组学的国家和地区的研究能力建设，并提供最先进的微阵列服务。这包括提供对蛋白质组学和微阵列设施至关重要的生物信息学服务。4.扩大我们的区域和国家努力，分享研究资源。5.通过一套新的评估工具评估VGN的进展情况。我们的应用程序的新建议方面包括通过扩大的BPI网络扩大劳动力发展工作，并将CCV纳入我们的推广计划。加强蛋白质组学、微阵列和生物信息学的设施和服务，促进区域和国家研究资源的共享。评估的逻辑模型和输出时间线将是我们评估计划的重要补充。

项目成果

Fidelity escape by the unnatural amino acid β-hydroxynorvaline: an efficient substrate for Escherichia coli threonyl-tRNA synthetase with toxic effects on growth.

• DOI: 10.1021/bi101360a
• 发表时间: 2011-02-15
• 期刊: BIOCHEMISTRY
• 影响因子: 2.9
• 作者: Minajigi, Anand;Deng, Bin;Francklyn, Christopher S.
• 通讯作者: Francklyn, Christopher S.

Spontaneous recovery but not reinstatement of the extinguished conditioned eyeblink response in the rat.

• DOI: 10.1037/a0023582
• 发表时间: 2011-08
• 期刊: BEHAVIORAL NEUROSCIENCE
• 影响因子: 1.9
• 作者: Thanellou, Alexandra;Green, John T.
• 通讯作者: Green, John T.

Magnetic circular dichroism study of a dicobalt(II) complex with mixed 5- and 6-coordination: a spectroscopic model for dicobalt(II) hydrolases.

• DOI: 10.1021/ic901000d
• 发表时间: 2009-09-21
• 期刊: INORGANIC CHEMISTRY
• 影响因子: 4.6
• 作者: Larrabee, James A.;Johnson, W. Rainey;Volwiler, Adam S.
• 通讯作者: Volwiler, Adam S.

Genomic analysis of pterostilbene predicts its antiproliferative effects against pancreatic cancer in vitro and in vivo.

• DOI: 10.1007/s11605-012-1869-7
• 发表时间: 2012-06
• 期刊: JOURNAL OF GASTROINTESTINAL SURGERY
• 影响因子: 3.2
• 作者: McCormack, Denise Elizabeth;Mannal, Patrick;McDonald, Debbie;Tighe, Scott;Hanson, Joshua;McFadden, David
• 通讯作者: McFadden, David

The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells.

• DOI: 10.1084/jem.20081571
• 发表时间: 2009-01-16
• 期刊: The Journal of experimental medicine
• 作者: Dienz O;Eaton SM;Bond JP;Neveu W;Moquin D;Noubade R;Briso EM;Charland C;Leonard WJ;Ciliberto G;Teuscher C;Haynes L;Rincon M
• 通讯作者: Rincon M