Intrinsic hearing protection mechanisms: a pathway to prevention of noise-induced hearing loss

内在听力保护机制：预防噪声性听力损失的途径

• 批准号: nhmrc : 1089838
• 负责人: Prof Allen Ryan
• 金额: $ 41.74万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/intrinsic-hearing-protection-hearing-loss/519260
• 关键词: Intrinsic; hearing; protection; mechanisms; pathway

Noise-induced hearing loss (NIHL) is a significant contributor to the total burden of disease. We recently determined that when the ear is exposed to sustained noise, the cochlea is protected from damage by activation of a specific (P2X2) receptor, evident as reversible hearing adaptation. This study will determine the downstream signalling from this receptor. This will support assessment of vulnerability to NIHL and contribute to development of hearing therapeutics.

噪声性听力损失（NIHL）是疾病总负担的一个重要因素。我们最近确定，当耳朵暴露在持续的噪音中时，耳蜗会通过激活特定的 (P2X2) 受体而免受损伤，这表现为可逆的听力适应。这项研究将确定该受体的下游信号传导。这将支持评估 NIHL 的脆弱性并有助于听力治疗的发展。