Oxytocin and Social Engagement

催产素和社交参与

• 批准号: 8914994
• 负责人: Amanda Cristina Venta
• 金额: $ 3.53万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8914994
• 关键词: Accounting; Address; Adolescence; Adolescent; Adult; Affect; Age; American; Animals; Autistic Disorder; Award; Behavior; Behavioral; Biological; Brain region; Cereals; Charge; Child; Classification; Clinical; Clinical Research; Communities; Computers; Data; Diagnostic; Double-Blind Method; Faculty; Health Personnel; Individual; Inpatients; Internet; Intervention; Interview; Investments; Lead; Mental Health; Mental disorders; Mission; Mothers; National Institute of Child Health and Human Development; National Institute of Mental Health; Neurobiology; Oxytocin; Parent-Child Relations; Parents; Perception; Personal Satisfaction; Placebo Control; Placebo Effect; Placebos; Play; Population; Postdoctoral Fellow; Process; Provider; Psychopathology; Public Health; Publications; Randomized; Recruitment Activity; Research; Research Personnel; Role; Sampling; Secure; Security; Self-Administered; Social Behavior; Social Environment; Suggestion; Symptoms; Therapeutic; Time; Training; Trust; Work; age group; base; blind; career; design; in vivo; neurobiological mechanism; neuroeconomics; novel; public health relevance; relating to nervous system; sex; social; social attachment; tool; willingness

DESCRIPTION (provided by applicant): Existing research with animals and human adults suggests that oxytocin is a promising therapeutic tool because it increases trust and attachment in social relationships-key factors in a range of psychiatric disorders. Oxytocin has been recommended as a treatment for psychopathology in adolescents, a population in which treatment providers are wary of other pharmacological options. However, this suggestion remains largely unfounded, with only one previous study administering oxytocin to adolescents with psychopathology. Against this background, the objectives of the current application are to (a) examine the effect of intranasal oxytocin administration on trust behavior towards mothers in a game designed to assess in vivo, quantifiable social behavior, determining how this effect differs among inpatient and healthy control adolescents and (b) explore baseline attachment security as a moderator within each group to determine whether the effect differs depending upon the existing social relationship. A secondary aim is to explore, for the first time, how dimensionally rated psychopathology relates to the effect of oxytocin on trust. The central hypothesis is that oxytocin will increase trust behavior in the whole sample, and demonstrate clinical potential by raising the level of trust in the inpatient sample nearer to the trust behavir of community adolescents. Within each group, oxytocin is expected to increase trust behavior to a greater degree among adolescents with a secure attachment style. The approach is to recruit 100 inpatient adolescents and 100 healthy controls for a randomized, double blind, placebo-controlled design in which they self- administer intranasal oxytocin or a placebo and play a trust game with their mother over the internet. At the completion of this project, it is the expectation that the effect of oxytocin on adolescent-parent trust behavior among inpatients and healthy controls and the moderating role of attachment security will be determined. Moreover, valuable pilot data regarding the relation between oxytocin effects and internalizing and externalizing symptoms will be collected as the basis of more fine-grained analyses, continuing this promising line of research to post-doctoral study. The impact of this study is taking a first step towards determining whether, and for whom, oxytocin may have clinical value by increasing trust, within the context of the critical variables of attachment and symptomatology in adolescents. In addition to addressing the NICHD emphasis on the social context of adolescent mental health, this proposal reflects the mission of the NIMH by seeking to understand adolescent mental illness via the neurobiological mechanisms associated with attachment and trust; using a novel experimental task; and integrating data on the effect of oxytocin on behavioral (trust) and experiential (attachment) variables. Moreover, secondary analyses echo RDoC's charge to study psychopathology dimensionally, cutting across diagnostic boundaries. Finally, this award will aid in the training of a young researcher for an independent research career.

描述（由申请人提供）：现有的动物和成人研究表明，催产素是一种有前途的治疗工具，因为它增加了社会关系中的信任和依恋-一系列精神疾病的关键因素。催产素已被推荐作为青少年精神病理学的治疗方法，在这个人群中，治疗提供者对其他药物选择持谨慎态度。然而，这一建议在很大程度上仍然是没有根据的，只有一个先前的研究管理催产素与青少年的精神病理学。在此背景下，本申请的目的是（a）在设计用于评估体内可量化的社会行为的游戏中，检查鼻内催产素施用对对母亲的信任行为的影响，确定这种效应在住院和健康对照青少年中的差异，以及（B）探索基线依恋安全性作为每个组内的调节器，以确定是否影响不同，取决于现有的社会关系。第二个目的是探索，第一次，维度评定的精神病理学如何与催产素对信任的影响有关。中心假设是，催产素将增加整个样本的信任行为，并通过提高住院样本的信任水平接近社区青少年的信任行为，显示临床潜力。在每一组中，催产素预计将在更大程度上增加具有安全依恋风格的青少年的信任行为。该方法是招募100名住院青少年和100名健康对照，进行随机、双盲、安慰剂对照设计，其中他们自我给予鼻内催产素或安慰剂，并通过互联网与他们的母亲玩信任游戏。在本研究完成后，我们期望能够确定催产素对住院患者和健康对照者的亲-亲信任行为的影响以及依恋安全性的调节作用。此外，将收集关于催产素效应与内化和外化症状之间关系的有价值的试点数据，作为更细粒度分析的基础，继续这一有前途的博士后研究。这项研究的影响是采取第一步，以确定是否，以及对谁来说，催产素可能具有临床价值，通过增加信任，在青少年的依恋和依恋学的关键变量的背景下。除了解决NICHD强调青少年心理健康的社会背景，这一建议反映了NIMH的使命，通过与依恋和信任相关的神经生物学机制来理解青少年心理疾病;使用一种新的实验任务;并整合催产素对行为（信任）和经验（依恋）变量的影响数据。此外，二次分析呼应RDoC的收费研究精神病理学的维度，跨越诊断界限。最后，该奖项将有助于培训年轻研究人员从事独立的研究生涯。