Multiplex detection array with anchored derivatization for environmental monitori

用于环境监测的具有锚定衍生化的多重检测阵列

• 批准号: 8715195
• 负责人: Steve Michael Savoy
• 金额: $ 22.5万
• 依托单位: NANOHMICS, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8715195
• 关键词: Address; Adverse effects; Biological; California; Chemicals; Collaborations; Collection; Column Chromatography; Complex; Complex Mixtures; Computer software; Concentration measurement; Custom; Data; Data Collection; Databases; Detection; Development; Device Designs; Devices; Diagnostic; Diffusion; Dimensions; Dose; Electronics; Elements; Environment; Environmental Health; Environmental Monitoring; Epidemiology; Exposure to; Film; Gas Chromatography; Gases; Goals; Health; Hexanes; Home environment; Human; Human Biology; Indium; Individual; Institutes; Laboratories; Lead; Libraries; Mass Spectrum Analysis; Measurement; Metals; Methods; Mission; Monitor; Nanotubes; Nucleic Acids; Oligonucleotides; Pattern; Peptide Nucleic Acids; Peptides; Personal Satisfaction; Phase; Physiological; Power Sources; Printing; Process; Reading; Reagent; Research; Safety; Sampling; Science; Security; Semiconductors; Solvents; Source; Spottings; Staging; Surface; System; Techniques; Technology; Thick; Time; Toluene; Toxic effect; Transducers; Universities; Vacuum; Work; Workplace; Xylene; air monitoring; austin; base; detector; hazard; manufacturing process; metal oxide; method development; monitoring device; multiplex detection; nanoimprint lithography; nanoparticle; nanoscale; nanowire; population based; professor; programs; protein aminoacid sequence; prototype; public health relevance; response; sensor; solid state; technology development; tool; vapor; volatile organic compound

DESCRIPTION: Complex, multi-analyte vapor analysis is routinely achieved using laboratory tools such as gas chromatography combined with mass spectrometry (GC-MS). However, these systems are not readily configurable for compact, low- concentration, near real-time environmental tracking of vapors (e.g. a wearable data logging badge), which is a stated technology development goal of the National Institute of Environmental Health and Safety (NIEHS). To address this need, Nanohmics Inc., an early-stage technology development company (Austin, TX) is currently developing OmniScense detection technology, a low profile, vapor-phase environment analysis device for monitoring air quality and toxicity at levels that are pertinent to environmental health and safety. Prototype OmniScensor devices developed to date have been used to identify and quantify common solvents and other volatile organic compounds (VOCs) via direct electrical detection with chemiresistive metal oxide semiconductor (MOx) arrays patterned using the method of NanoImprint Lithography (NIL). This approach provides greater vapor component selectivity and quantification capabilities over a large concentration dynamic range by controlling the dimensions of the sensor element at the nanoscale. Dimensional control is not readily achieved with existing commercial MOx thin films, or with research platforms based on composite transducers (e.g. nanowires, nanotubes, metal nanoparticles and graphene). In addition to sensor feature size control, further surface derivatization will provide a means to discriminate chemically similar vapor species (e.g. nonpolar toluene, xylene and hexane), thereby enabling complex analysis across the broad set of chemical functionality ranging from highly polarizing carrier acceptors/donators to nonpolar volatile gases/organics.

产品说明：复杂的多分析物蒸气分析通常使用实验室工具实现，例如气相色谱-质谱联用（GC-MS）。然而，这些系统不容易被配置用于蒸汽的紧凑、低浓度、近实时环境跟踪（例如，可穿戴数据记录徽章），这是国家环境健康与安全研究所（NIEHS）的既定技术开发目标。为了满足这一需求，Nanohydrate Inc.，一家处于早期阶段的技术开发公司（Austin，TX）目前正在开发OmniScense检测技术，这是一种用于在与环境健康和安全相关的水平上监测空气质量和毒性的低轮廓气相环境分析设备。迄今为止开发的原型OmniScensor设备已被用于通过使用纳米压印光刻（NIL）方法图案化的化学电阻金属氧化物半导体（MOx）阵列的直接电检测来识别和量化常见溶剂和其他挥发性有机化合物（VOC）。这种方法通过在纳米级控制传感器元件的尺寸，在大的浓度动态范围内提供更大的蒸气组分选择性和量化能力。现有的商业MOx薄膜或基于复合换能器（例如纳米线、纳米管、金属纳米颗粒和石墨烯）的研究平台不容易实现尺寸控制。除了传感器特征尺寸控制之外，进一步的表面衍生化将提供一种区分化学上相似的蒸气物质（例如，非极性甲苯、二甲苯和己烷）的方法，从而能够对从高度极化的载体受体/供体到非极性挥发性气体/有机物的广泛的化学功能进行复杂的分析。