Ambulatory cryocooling therapy device

门诊冷冻治疗装置

• 批准号: 10783172
• 负责人: Steve Michael Savoy
• 金额: $ 70.28万
• 依托单位: NANOHMICS, INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-23 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10783172
• 关键词: Ambulatory; cryocooling; therapy; device

PI: Savoy Project Summary Tissue protection following injury begins with shutting down vasodilation and limiting subsequent swelling through the application of cold. In many cases, the cold comes in the form of bags of ice or frozen cold packs, or commercial cooling products such ice packs or ice pack holding limb wraps. In others it may be via a chilled water circulator device, for example the Polar Care Kodiak Cold Therapy where ice water is sent from the “holding box” through ¾” tubing into a cooling pad applied to the skin. The drawback with ice and frozen packs is the risk of skin burn and soft tissue damage stemming from skin contact with such a low temperature. With as little as 20-30 minutes of an icepack lying against the skin, damage may occur. However, studies have shown that 20 minutes of cooling one time is not enough to change the course of treatment and decrease the swelling. Longer term cooling is needed to make a difference. However, the patient’s functional mobility and compliance is limited due the bulk of the apparatus, and this discourages longer term use and increases risks associated with deep vein thrombosis which combine decrease patient outcome. Ideally, the device could be worn “hands-free” for extended periods providing a long-term (full day) programmable therapeutic regimen which includes periods of anti-inflammation (T ~ 10 °C) followed by brief periods of elevated temperature (T ~ 20 °C) to prevent skin damage. An alternative electrical-to-thermal cooling device that could be applied directly to the injury site would increase patient adoption and improve patient therapy benefit. Nanohmics’ direct electric-to-thermal approach to address this shortcoming will provide programmable temperature control over the entire contact region in a low-profile, low-power consumption device that will enable the patient full ambulatory freedom during the therapeutic regimen after injury (e.g. ankle/wrist sprain) or surgery (e.g. knee arthroscopy). No ice means there are no issues with melting and replacement, and the temperature can be programmed for cold (anti- inflammatory) and heat (cellular debris clearing, thrombosis) which may lead to benefits in decreased pain medicine consumption, post-injury range of motion, and decreased pain score and risks associated with deep vein thrombosis.

PI：萨沃伊 项目摘要 损伤后的组织保护始于关闭血管舒张和限制 随后通过施加寒冷而肿胀。在许多情况下，感冒是以 冰袋或冷冻冰袋，或商业冷却产品，例如冰袋或冰袋 拿着四肢绷带在其他情况下，其可以经由冷冻水循环器装置，例如， Polar Care Kodiak冷疗，冰水从“保温箱”通过” 将导管插入敷在皮肤上的冷却垫中。冰和冷冻包的缺点是风险 皮肤烧伤和软组织损伤的可能性。 只要用冰袋敷在皮肤上20-30分钟，就可能造成损害。 然而，研究表明，一次冷却20分钟不足以改变 治疗过程中，并减少肿胀。需要更长时间的冷却， 差然而，患者的功能移动性和顺应性由于大部分的 这阻碍了长期使用，并增加了与深度相关的风险。 静脉血栓形成联合收割机降低了患者的预后。理想情况下，该设备可以佩戴在 长时间“免提”，提供长期（全天）可编程治疗 治疗方案包括抗炎期（T ~ 10 °C），随后是短暂的 高温（T ~ 20 °C）可防止皮肤损伤。 一种可直接应用于伤口的替代电热冷却装置 研究中心将增加患者采用率并改善患者治疗受益。纳米直接 解决这一缺点的电热方法将提供可编程的 以低轮廓、低功耗的方式对整个接触区域进行温度控制 该设备将使患者在治疗方案期间能够完全走动自由 损伤（如踝关节/手腕扭伤）或手术（如膝关节镜检查）。没有冰意味着没有 熔化和更换的问题，温度可以编程为冷（反- 炎症）和热（细胞碎片清除，血栓形成），这可能导致有益于 疼痛药物消耗减少，损伤后活动范围减少，疼痛评分降低 以及与深静脉血栓形成相关的风险。