Family and Neighborhood Interventions to Reduce Heart Disease Risk in East L.A.

描述(由申请人提供)：我们建议加州大学洛杉矶分校-南加州大学人口健康和健康差异中心(CPHHD)专注于降低加州东洛杉矶(东洛杉矶)拉丁裔的心血管疾病风险。东洛杉矶是一个与肥胖相关的慢性病发病率很高的城市社区，包括心脏病、糖尿病、高血压和中风。东洛杉矶有超过96%的拉丁裔，其中85%有墨西哥血统，其余主要来自中美洲。我们的主要目标是降低这一服务不足地区的心血管疾病风险。为了实现这一目标，我们有三个综合的、互补的项目、两个核心和一个培训和职业发展计划。我们将使用以社区为基础的参与式方法来实施家庭和邻里环境干预，同时收集生理数据，以检查个人和世代之间的风险。干预部分包括几个影响健康结果的维度--个人和家庭因素、系统因素和环境因素。项目一是家庭参与的强化家庭环境干预，其中一名成员是当地一家糖尿病护理诊所新登记的高危病例。项目2将检查不同世代和移民身份的个体的血管功能和心血管疾病风险生物标记物，以增加对拉丁裔文化适应悖论在心血管疾病风险中的基础的理解。项目3将对Comer商店进行改造，使它们能够销售和提供更健康的食物选择，并使它们成为培训社区成员关于更健康食物选择和餐饮准备策略的场所。该中心还将利用推广者和公共卫生新手参与干预活动的机会。公共卫生新秀将是从社区一所公立高中招募的青少年。这两个核心为项目提供行政和研究方法资源，培训和职业发展方案将提供资源和基础设施，为公共卫生新手提供管道，并将培训和指导研究生、博士后研究员和教职员工使用跨学科、缩小差距的研究。

DESCRIPTION (provided by applicant): We propose a UCLA-USC Center for Population Health and Health Disparities (CPHHD) that will focus on reducing cardiovascular disease risk among Latinos in East Los Angeles, California (East L.A.). East L.A. is an urban community with high rates of obesity-related chronic diseases including heart disease, diabetes, hypertension and stroke. East L.A. is over 96% Latino; 85% of whom have Mexican ancestry and the rest come mainly from Central America. Our primary objective is to reduce cardiovascular disease risk in this under-served area. To accomplish this objective, we have three integrated, complementary projects, two cores, and a Training and Career Development Program. We will use a community-based participatory approach to implement family and neighborhood environment interventions, along with the collection of physiological data that will examine risk in individuals and across generations. The intervention components include several dimensions that affect health outcomes - personal & family factors, systems factors, and environmental factors. Project 1 is an intensive home environment intervention involving families, of which one member is a high-risk case newly enrolled in a local diabetes care clinic. Project 2 will examine vascular function and cardiovascular disease risk biomarkers for individuals varying in generational and immigrant status, to increase the understanding of the basis for the Latino acculturation paradox in CVD risk. Project 3 will conduct make overs of comer stores to enable them to market and provide healthier food options, as well as enable them to serve as a venue for training community members about healthier food options and meal preparation strategies. The center will also capitalize on the inclusion of both promotoras and public health rookies in intervention activities. The public health rookies will be adolescents recruited from a public high school in the community. The two cores provide administrative and research methods resources to the projects, and the Training and Career Development Program will provide resources and infrastructure to provide a pipeline for the public health rookies and will train and mentor graduate students, post-doctoral fellows, and faculty on the use of interdisciplinary, disparities-reduction research.