SnapTag: Tagging active ensembles using a Strong Neuronal Activity Promoter

SnapTag：使用强神经元活动启动子标记活动整体

• 批准号: 8752270
• 负责人: Yingxi Lin
• 金额: $ 19.5万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-15 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8752270
• 关键词: Adaptive Behaviors; Address; Autistic Disorder; Behavior; Behavioral; Behavioral Paradigm; Bioinformatics; Biological Neural Networks; Brain; Brain region; Cells; Cognitive deficits; Communities; Coupled; Data; Dependovirus; Disease; Drosophila genus; Elements; Etiology; Genes; Genetic Enhancer Element; Goals; Health; Hippocampus (Brain); In Vitro; Individual; Information Storage; Investigation; Knowledge; Label; Lead; Light; Mental Depression; Modification; Molecular; Mus; Neurons; Neurosciences; Output; Pathology; Population; Process; Property; Rattus; Recruitment Activity; Reporter; Research; Rest; Schizophrenia; Sensory; Synapses; System; Work; base; conditioned fear; design; experience; in vivo; information processing; memory recall; nervous system disorder; neural circuit; neuropsychiatry; patch clamp; promoter; relating to nervous system; tool

DESCRIPTION (provided by applicant): The way in which sensory experience is captured and converted into long lasting changes in the brain is critical for adaptive behaviors. A deficit in sensory information processing is a pronounced feature shared by many devastating neuropsychiatric disorders such autism, schizophrenia and depression. Each experience activates a unique set of neurons within specific regions of the brain. While we now know in many cases the brain regions that are associated with particular types of sensory experience, we know very little about the identity of specific ensembles of neurons that are responsible for the encoding of specific sensory information, let alone the underlying molecular and cellular mechanisms. The goal of this proposed study is to fill this gap in our knowledge by developing a versatile system that allows for the identification and manipulation of ensembles of neurons as they participate in the processing of the influx of sensory information. Using this system, our long term goal is to explore the cellular and molecular mechanisms by which sensory experience is coupled to modification of the synaptic properties of neural networks and to understand how disruption of this process leads to cognitive deficits.

描述（由申请人提供）：感官体验被捕获并转化为大脑中持久变化的方式对适应性行为至关重要。感觉信息处理的缺陷是许多毁灭性的神经精神疾病（如自闭症、精神分裂症和抑郁症）共有的显著特征。每一种体验都会激活大脑特定区域内的一组独特的神经元。虽然我们现在知道在许多情况下，大脑区域与特定类型的感觉体验有关，但我们对负责编码特定感觉信息的特定神经元集合的身份知之甚少，更不用说潜在的分子和细胞机制了。这项拟议研究的目标是通过开发一种多功能系统来填补我们知识中的这一空白，该系统允许识别和操纵神经元的集合，因为它们参与处理感官信息的涌入。使用这个系统，我们的长期目标是探索细胞和分子机制，通过该机制，感觉体验与神经网络突触特性的改变相结合，并了解这一过程的中断如何导致认知缺陷。