Antiviral Drug Discovery and Development Center - Overall

描述（由申请人提供）：本文提出的卓越转化研究中心（CETR）将被命名为抗病毒药物发现和开发中心（AD3C），其中心主题是开发针对新发和再发病毒感染的新小分子疗法。转化研究将集中在病毒复制的抑制，特别是病毒聚合酶。进展途径将包括靶标验证，高通量筛选以确定新的化学支架，以及基础病毒学研究，以证明和进一步探索鉴定的铅分子在病毒复制中的确切作用机制。药物化学和先导物开发活动将沿着药物发现和开发途径推进已确定的化合物，最终导致有希望的候选药物的临床前评估，以进行临床评估。AD3C有四个相互关联的研究项目，重点是黄病毒、冠状病毒、甲病毒和流感。它们的工作将得到三个核心的支持：行政核心（核心A）；

DESCRIPTION (provided by applicant): The herein proposed Center of Excellence for Translational Research (CETR), which will be named the Antiviral Drug Discovery and Development Center (AD3C) has, at its center, the theme to develop new small molecule therapeutics for emerging and re-emerging viral infections. Translational research will focus on the inhibition of viral replication, especially viral polymerases. Progression pathways will includ target validation, high throughput screening to identify novel chemical scaffolds, and basic virologic research to prove and further probe the exact mechanism of action of identified lead molecules in viral replication. Medicinal chemistry and lead development activities will advance identified compounds down the drug discovery and development pathway, ultimately leading to preclinical evaluation of promising drug candidates for clinical evaluation. The AD3C has four interrelated research projects with a focus on flaviviruses, coronaviruses, alphaviruses and influenza. They will be supported in their efforts by three cores: an Administrative Core (Core A), a Screening Core (SC; Core B) and a Medicinal Chemistry and Lead Development Core (MCLDC; Core C). Organization and interaction between all projects and cores will be mediated out of the Administrative Core, with day to day AD3C operations led by the Core's personnel. An Executive Committee (EC) consisting of all project and core leaders will regularly review the projects' and cores' activities and productivity. Finally, an External Scientific Advisory Board (EAB) of distinguished scientists has been established to annually provide a high level evaluation of AD3C's progress and successes, and aid in refining the Center's activities and direction.