Antiviral Drug Discovery and Development Center - Overall

描述(由申请人提供)：本文建议的翻译研究英才中心(CETR)，将被命名为抗病毒药物发现和开发中心(AD3C)，其中心的主题是为新出现和重新出现的病毒感染开发新的小分子疗法。翻译研究将集中在抑制病毒复制，特别是病毒聚合酶。进展途径将包括靶标验证、高通量筛选以确定新的化学支架，以及基础病毒学研究以证明和进一步探索已识别的前导分子在病毒复制中的确切作用机制。药物化学和先导开发活动将在药物发现和开发过程中推进已识别的化合物，最终导致对有希望的候选药物进行临床前评估。AD3C有四个相互关联的研究项目，重点是黄病毒、冠状病毒、甲型病毒和流感。它们的努力将得到三个核心的支持：一个行政核心(核心A)， 一个筛选核心(SC；核心B)和一个药物化学和铅开发核心(MCLDC；核心C)。所有项目和核心之间的组织和互动将在行政核心之外进行调解，AD3C的日常运作将由核心的人员领导。由所有项目和核心领导人组成的执行委员会(EC)将定期审查项目和核心的活动和生产率。最后，成立了一个由杰出科学家组成的外部科学顾问委员会(EAB)，每年对AD3C的进展和成功进行高级别评估，并帮助完善中心的活动和方向。

DESCRIPTION (provided by applicant): The herein proposed Center of Excellence for Translational Research (CETR), which will be named the Antiviral Drug Discovery and Development Center (AD3C) has, at its center, the theme to develop new small molecule therapeutics for emerging and re-emerging viral infections. Translational research will focus on the inhibition of viral replication, especially viral polymerases. Progression pathways will includ target validation, high throughput screening to identify novel chemical scaffolds, and basic virologic research to prove and further probe the exact mechanism of action of identified lead molecules in viral replication. Medicinal chemistry and lead development activities will advance identified compounds down the drug discovery and development pathway, ultimately leading to preclinical evaluation of promising drug candidates for clinical evaluation. The AD3C has four interrelated research projects with a focus on flaviviruses, coronaviruses, alphaviruses and influenza. They will be supported in their efforts by three cores: an Administrative Core (Core A), a Screening Core (SC; Core B) and a Medicinal Chemistry and Lead Development Core (MCLDC; Core C). Organization and interaction between all projects and cores will be mediated out of the Administrative Core, with day to day AD3C operations led by the Core's personnel. An Executive Committee (EC) consisting of all project and core leaders will regularly review the projects' and cores' activities and productivity. Finally, an External Scientific Advisory Board (EAB) of distinguished scientists has been established to annually provide a high level evaluation of AD3C's progress and successes, and aid in refining the Center's activities and direction.