Core 3: Pilot p342-353

核心 3：试点 p342-353

• 批准号: 8737868
• 负责人: SUCHITRA KRISHNAN-SARIN
• 金额: $ 36.7万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8737868
• 关键词: Animal Experimentation; Applications Grants; Award; Basic Science; Behavioral; Clinical; Collaborations; Communities; Complement; Development; Economics; Ensure; Epidemiology; Extramural Activities; Faculty; Fostering; Funding; Future; Goals; Grant; Human; Interdisciplinary Study; International; Laboratories; Marketing; Mentors; Molecular; Monitor; Nature; Pilot Projects; Process; Publications; Recording of previous events; Reporting; Research; Research Personnel; Research Project Grants; Risk; Risk Factors; Role; Science; Site; Structure; System; Tobacco; Tobacco Dependence; Tobacco use; Training; Training and Education; Transdisciplinary Tobacco Research Center; Treatment Failure; United States National Institutes of Health; Universities; addiction; career development; experience; knowledge base; meetings; member; novel strategies; programs; response; symposium; web site

The goal of the Pilot Core is to galvanize research within and outside the Yale Tobacco Center of Regulatory Science (TCORS) and to allow investigators to develop preliminary evidence that would enable submission of highly competitive extramural funding applications. The 4 research components of the Yale TCORS focus on understanding the role of tobacco additives and modified risk tobacco products through behavioral, molecular, pharmacological, epidemiological, and economic sciences that involve humans (in clinical, economic, and epidemiological research) and animals (basic research). Projects funded by the Pilot Core will reflect and complement these goals. The Pilot Core will be responsible for review, funding, and oversight of up to 5 TCORS pilot projects per year that are relevant to the goals of the Yale TCORS of reducing the addiction to tobacco products, to the goals of the other TCORS sites, and to the regulatory needs ofthe FDA. Further, in conjunction with the Laboratory and Administrative Cores, the Pilot Core will facilitate the training of junior investigators in the Education and Training Core by providing them with funds to initiate independent research projects that are relevant to tobacco regulatory science. Researchers involved in this proposed TCORS at Yale University have an established history of conducting programs of multidisciplinary research in tobacco use. From 2000-2011, we led an NIH Transdisciplinary Tobacco Use Research Center (TTURC) focused on tobacco dependence and risk factors for treatment failure in order to ultimately develop new approaches for treatment. As part of this effort we successfully solicited and reviewed pilot projects, and supported funding for 33 pilot projects. Fifty-two publications and 14 NIH funded grants resulted from these pilots. Moreover, the TTURC and its pilot mechanism led to the creation and cohesiveness of the Center for Tobacco Use Research at Yale (CENTURY), a core group of more than 25 faculty members who focus on tobacco research (CENTURY website: http://centurv.vale.edu) and has further stimulated tobacco research and collaborations within and outside the Yale community. Thus, our previous experience demonstrates our ability to successfully accomplish the proposed activities.

飞行员核心的目的是在耶鲁烟草中心和外部的研究中加剧研究 监管科学（TCORS），并允许研究人员开发初步证据 提交高度竞争性的校外资金应用程序。耶鲁大学的4个研究组件 TCOR专注于了解烟草添加剂和改良风险烟草产品的作用 行为，分子，药理，流行病学和涉及人类的经济科学（在 临床，经济和流行病学研究）和动物（基础研究）。飞行员资助的项目 核心将反映和补充这些目标。飞行员核心将负责审查，资金和 每年对多达5个TCOR的飞行员项目的监督，这些项目与耶鲁TCOR的目标有关 减少对烟草产品的成瘾，其他TCORS网站的目标以及监管需求 fda。此外，与实验室和行政核心一起，飞行员核心将有助于 通过为他们提供资金来启动教育和培训核心的初级调查人员的培训 与烟草监管科学相关的独立研究项目。 参与耶鲁大学拟议TCOR的研究人员有既定的指导史 烟草使用多学科研究的计划。从2000年至2011年，我们领导了NIH跨学科 烟草使用研究中心（TTURC）着重于烟草依赖性和治疗失败的危险因素 为了最终开发新的治疗方法。作为这项努力的一部分，我们成功征求了 审查了试点项目，并为33个试点项目提供了资金。 52个出版物和14个NIH资助 这些飞行员​​造成的赠款。此外，TTURC及其试验机制导致了创造和 耶鲁（Century）的烟草使用研究中心的凝聚力，超过25岁的核心群体 专注于烟草研究的教职员工（世纪网站：http：//centurv.vale.edu），并进一步 耶鲁社区内外刺激了烟草研究和合作。因此，我们的先前 经验证明了我们成功完成拟议活动的能力。