Core 3: Pilot p342-353

核心 3：试点 p342-353

• 批准号: 8737868
• 负责人: SUCHITRA KRISHNAN-SARIN
• 金额: $ 36.7万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8737868
• 关键词: Animal Experimentation; Applications Grants; Award; Basic Science; Behavioral; Clinical; Collaborations; Communities; Complement; Development; Economics; Ensure; Epidemiology; Extramural Activities; Faculty; Fostering; Funding; Future; Goals; Grant; Human; Interdisciplinary Study; International; Laboratories; Marketing; Mentors; Molecular; Monitor; Nature; Pilot Projects; Process; Publications; Recording of previous events; Reporting; Research; Research Personnel; Research Project Grants; Risk; Risk Factors; Role; Science; Site; Structure; System; Tobacco; Tobacco Dependence; Tobacco use; Training; Training and Education; Transdisciplinary Tobacco Research Center; Treatment Failure; United States National Institutes of Health; Universities; addiction; career development; experience; knowledge base; meetings; member; novel strategies; programs; response; symposium; web site

The goal of the Pilot Core is to galvanize research within and outside the Yale Tobacco Center of Regulatory Science (TCORS) and to allow investigators to develop preliminary evidence that would enable submission of highly competitive extramural funding applications. The 4 research components of the Yale TCORS focus on understanding the role of tobacco additives and modified risk tobacco products through behavioral, molecular, pharmacological, epidemiological, and economic sciences that involve humans (in clinical, economic, and epidemiological research) and animals (basic research). Projects funded by the Pilot Core will reflect and complement these goals. The Pilot Core will be responsible for review, funding, and oversight of up to 5 TCORS pilot projects per year that are relevant to the goals of the Yale TCORS of reducing the addiction to tobacco products, to the goals of the other TCORS sites, and to the regulatory needs ofthe FDA. Further, in conjunction with the Laboratory and Administrative Cores, the Pilot Core will facilitate the training of junior investigators in the Education and Training Core by providing them with funds to initiate independent research projects that are relevant to tobacco regulatory science. Researchers involved in this proposed TCORS at Yale University have an established history of conducting programs of multidisciplinary research in tobacco use. From 2000-2011, we led an NIH Transdisciplinary Tobacco Use Research Center (TTURC) focused on tobacco dependence and risk factors for treatment failure in order to ultimately develop new approaches for treatment. As part of this effort we successfully solicited and reviewed pilot projects, and supported funding for 33 pilot projects. Fifty-two publications and 14 NIH funded grants resulted from these pilots. Moreover, the TTURC and its pilot mechanism led to the creation and cohesiveness of the Center for Tobacco Use Research at Yale (CENTURY), a core group of more than 25 faculty members who focus on tobacco research (CENTURY website: http://centurv.vale.edu) and has further stimulated tobacco research and collaborations within and outside the Yale community. Thus, our previous experience demonstrates our ability to successfully accomplish the proposed activities.

Pilot Core的目标是激励耶鲁大学烟草中心内外的研究 监管科学(TCORS)，并允许调查人员开发初步证据，以使 提交竞争激烈的校外资金申请。耶鲁大学的四个研究组成部分 TCORS侧重于通过以下途径了解烟草添加剂和经修饰的风险烟草产品的作用 涉及人类的行为、分子、药理学、流行病学和经济学(在 临床、经济和流行病学研究)和动物(基础研究)。试点资助的项目 CORE将反映和补充这些目标。Pilot Core将负责审查、资助和 每年监督多达5个与耶鲁TCORS目标相关的TCORS试点项目 减少对烟草产品的依赖，实现其他TCORS网站的目标，满足监管需要 美国食品和药物管理局。此外，与实验室和行政核心一起，试点核心将促进 对初级调查人员进行教育和培训核心培训，为他们提供启动资金 与烟草监管科学相关的独立研究项目。 耶鲁大学参与这项拟议的TCORS的研究人员已经有了进行 烟草使用方面的多学科研究计划。从2000年到2011年，我们领导了一项NIH跨学科 烟草使用研究中心(TTURC)专注于烟草依赖和治疗失败的风险因素 以便最终开发新的治疗方法。作为这项努力的一部分，我们成功地征集了 审查试点项目，支持资助33个试点项目。52份出版物和14份美国国立卫生研究院资助 从这些飞行员那里获得了赠款。此外，TTURC及其试点机制导致了 耶鲁(CENTURY)烟草使用研究中心的凝聚力，这是一个超过25人的核心小组 专注于烟草研究的教职员工(世纪网站：http://centurv.vale.edu)，并有更多 促进了耶鲁社区内外的烟草研究和合作。因此，我们之前的 经验表明，我们有能力成功完成拟议的活动。