Yale Tobacco Center of Regulatory Science

耶鲁大学烟草监管科学中心

• 批准号: 9131690
• 负责人: SUCHITRA KRISHNAN-SARIN
• 金额: $ 399.24万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9131690
• 关键词: Address; Adolescence; Adolescent; Adolescent and Young Adult; Adult; Affect; Basic Science; Biological Assay; Biology; Brain; Chronic; Cigarette; Clinical; Clinical Sciences; Collaborations; Communication; Decision Making; Development; Discipline; Drug Kinetics; Electronic cigarette; Epidemic; Evaluation; Exposure to; Faculty; Family Smoking Prevention and Tobacco Control Act; Flavoring; Foundations; Funding; Generations; Goals; Guidelines; Health; Human; Interdisciplinary Study; Irritants; Knowledge; Laboratories; Maintenance; Marketing; Menthol; Mentors; Methods; Mus; Nature; Nicotinic Receptors; Pathway interactions; Pilot Projects; Policies; Population; Population Sciences; Postdoctoral Fellow; Prevention; Principal Investigator; Process; Psychophysics; Public Health; Rattus; Research; Research Design; Research Personnel; Research Project Grants; Research Technics; Rewards; Risk; Role; Sales; Sarin; Science; Scientist; Series; Signal Transduction; Smokeless Tobacco; Smoker; Sweetening Agents; TRP channel; Tobacco; Tobacco Dependence; Tobacco use; Training; Training and Education; Transdisciplinary Tobacco Research Center; Vulnerable Populations; addiction; authority; base; behavioral pharmacology; design; drug of abuse; education research; empowered; experience; health economics; interest; knowledge base; method development; multidisciplinary; non-smoker; population based; preference; programs; public policy on tobacco; receptor; standardize measure; uptake

DESCRIPTION (provided by applicant): The Family Smoking Prevention and Tobacco Control Act, by empowering the FDA to regulate tobacco products, makes the crucial goal of reducing the appeal, addiction, and harmful effects of all tobacco products, including current and emerging modified risk tobacco products (MRTP's) more achievable. The overarching goal of the Yale Tobacco Center of Regulatory Science is to reduce addiction by developing a strong knowledge base on how flavors, including menthol, and sweeteners affect the initiation and development of addiction to current tobacco and modified risk tobacco products. Translational in nature, the four proposed studies bridge basic, clinical and population science. The Yale TCORS multidisciplinary team includes experts in chemosensory psychophysics (Barry Green), menthol and irritant receptor biology (Sven Jordt; Green), dopaminergic signaling in brain reward pathways (Nil Addy), nicotinic receptor biology (Marina Picciotto), adolescent tobacco use (Suchitra Krishnan-Sarin), human behavioral pharmacology (Mehmet Sofuoglu), tobacco addiction (Stephanie O'Malley/Benjamin Toll), clinical pharmacokinetics of drugs of abuse (Peter Jatlow), and health economics and decision making science (Jody Sindelar/Johanna Maclean).The proposed center addresses the following specific aims: 1) To galvanize research interest across disciplines and to provide the FDA with empirical evidence that might be used to develop policies to reduce addiction to tobacco products, 2) To conduct a series of programmatic studies to understand the role of flavors and sweeteners, including menthol, in modulating addictive potential of tobacco products, 3) To train a new generation of researchers who have experience in regulatory research and can synthesize evidence from multiple disciplines to generate tobacco policies, 4) To facilitate collaborations within and across centers through the use of standardized measures and methods, and development of collaborative research projects, 5) To provide a mechanism for rapid review and funding of pilot projects which support the goals of the Yale TCORS and other TCORS, and are also responsive to the ongoing regulatory needs of the FDA. RELEVANCE: This center will conduct programmatic research to examine the influence of flavors, and related factors, on preference for and addiction to tobacco products. The center will also train a new generation of scientists, and provide pilot funding to stimulate research related to tobacco regulatory science. This comprehensive effort will help the FDA develop science based policies to reduce addiction to tobacco products.

描述（由申请人提供）：通过赋予FDA调节烟草产品的能力，《家庭预防和烟草控制法》的关键目标是减少所有烟草产品的吸引力，成瘾和有害影响，包括当前和新兴改装的风险烟草产品（MRTP）更加可实现的目标。耶鲁大学烟草科学中心的总体目标是通过建立强大的知识基础来减少成瘾，包括薄荷醇（包括薄荷醇）和甜味剂如何影响对当前烟草和改良风险烟草产品的成瘾的启动和发展。本质上的翻译是，这四个研究桥梁基本，临床和人口科学桥梁。 Yale TCOR的多学科团队包括化学体质心理物理学（Barry Green），Menthol和刺激性受体生物学（Sven Jordt; Green），大脑奖励途径中的多巴胺能信号传导（NIL ADDY）（NIL ADDY），烟碱受体生物学（Marina picciotto tobacco krishan krishan krishan krishan krishan krishan krishan krishan krishan krishan krishan krishan krishan， （Mehmet Sofuoglu），烟草成瘾（Stephanie O'Malley/Benjamin Toll），临床滥用药物（Peter Jatlow）的临床药代动力学（Peter Jatlow），以及健康经济学和决策科学（Jody Sindelar/Johanna MacLean）。经验证据可能被用来制定政策以减少烟草产品的成瘾，2）进行一系列程序性研究，以了解烟草产品中的风味和甜味剂（包括薄荷醇）在包括烟草产品上的成瘾潜力中的作用，3）以训练一系列新一代研究人员，可以在多种方面进行综合的研究，从而使多个学科的研究能够构成多种造型效果，从而使果皮繁殖效率繁多。通过使用标准化措施和方法，以及协作研究项目的开发，5）在中心内部和整个中心内部，提供了一种快速审查和资助飞行员项目的机制，这些试点项目支持耶鲁TCOR和其他TCOR的目标，并对FDA的持续监管需求做出响应。 相关性：该中心将进行程序化研究，以检查口味和相关因素对偏爱和成瘾烟草产品的影响。该中心还将培训新一代的科学家，并提供试点资金来刺激与烟草监管科学有关的研究。这项全面的努力将有助于FDA制定基于科学的政策，以减少对烟草产品的成瘾。