2014 Plasminogen Activation and Extracellular Proteolysis Gordon Research Confere

描述(由申请者提供)：为2014年纤溶酶原激活和胞外蛋白分解戈登研究会议(GRC)和戈登研究研讨会(GRS)寻求部分资金支持。这些是在同一地点连续举行的配对会议，2012年2月8日至9日为GRS，2月9日至14日为GRC。GRC自1990年以来每两年连续举办一次，在国际上享有盛誉。它聚集了一群具有不同科学背景的高度积极的参与者，他们在与纤溶酶原激活系统和相关的细胞外蛋白水解酶相关的研究前沿以“非正式”的方式进行密集但非正式的讨论。因此，这次会议为来自广泛学科的世界领先研究人员提供了一个独特的机会，展示他们关于纤溶酶原激活和细胞外蛋白分解的最新未发表研究，并讨论将他们的研究转化为新疗法的创新方法。组织纤溶酶原激活剂(TPA)在本领域的研究已经成功地用于治疗广泛的血栓栓塞性疾病，并发现了纤溶酶原激活系统胞外蛋白分解在许多生理和病理过程中的重要作用。在2014年的会议上，重点将放在机制、成像和治疗学上。2014年GRC将由我们的主旨发言人罗杰·钱存训发起，他是发现绿色荧光蛋白的诺贝尔奖获得者，他将讨论新的蛋白酶探针。将讨论在血管生物学、中枢神经系统功能和功能障碍、创伤性脑损伤、阿尔茨海默病、组织稳态和再生、造血、干细胞生物学、代谢和肥胖、肿瘤生物学、心血管功能和血管生成方面的突破性发现。将介绍在蛋白水解酶领域中的生物医学成像和生物工程的新模式。由于将基础研究转化为治疗是2014年会议的主要重点，因此将讨论生物标记物、药物输送和新疗法领域的前沿问题。与会者将通过邀请和在线提交的申请进行选择。他们将被选为代表不同研究人员的代表，重点是让妇女和代表性不足的少数群体作为讨论的领导者和发言者，并将继续作为海报主持人和与会者。相关的GRS是一项新颖的功能，将为年轻科学家提供一个分享GRC经验的独特机会。这个为期两天的研讨会将由研究生和博士后研究员在领先研究人员的支持下组织，并将允许纤溶酶原激活和细胞外蛋白分解领域的初级研究人员聚集在一起讨论他们目前的研究，同时与他们的同行建立非正式的网络，可能导致终身合作和科学成就。

DESCRIPTION (provided by applicant): Funds are sought for partial support of the 2014 Plasminogen Activation and Extracellular Proteolysis Gordon Research Conference (GRC) and Gordon Research Seminar (GRS). These are paired conferences held sequentially at the same location, February 8-9, 2012 for the GRS, and February 9-14 for the GRC. The GRC has been held continuously every two years since 1990 and enjoys an outstanding international reputation. It brings together a group of highly motivated participants with diverse scientific backgrounds that engage in intensive, yet informal, discussions at the frontier of research related to the plasminogen activation system and associated extracellular proteases in an "off-the-record" fashion. The conference thus provides a unique opportunity for the leading researchers in the world from a broad range of disciplines to present their latest unpublished research related to plasminogen activation and extracellular proteolysis, and to discuss innovative ways to translate their research into new therapies. Previous research in our field has led to the development of tissue plasminogen activator (tPA) for the successful treatment of a wide range of thromboembolic disorders, and the discovery of important roles for the plasminogen activation system extracellular proteolysis in a number of physiologic and pathologic processes. In the 2014 meeting, emphasis will be placed on Mechanisms, Imaging, and Therapeutics. The 2014 GRC will be launched by our Keynote Speaker Roger Tsien, Nobel Laureate for the discovery of GFP, who will discuss novel protease probes. Breakthrough findings in plasminogen activation and extracellular proteolysis in vascular biology, central nervous system function and dysfunction, traumatic brain injury, Alzheimer's disease, tissue homeostasis and regeneration, hematopoiesis, stem cell biology, metabolism and obesity, tumor biology, cardiovascular function, and angiogenesis will be discussed. Novel modalities of biomedical imaging and bioengineering in the field of proteases will be presented. Since translating basic research into treatments is a major focus of the 2014 meeting, the cutting- edge in biomarkers, drug delivery, and new therapies in our field will be discussed. Attendees will be selected by invitation and from applications submitted online. They will be chosen to represent a diverse spectrum of researchers, and a strong emphasis has been made on the inclusion of women and underrepresented minorities as Discussion Leaders and Speakers, and will continue on Poster Presenters, and Attendees. The associated GRS is a novel feature that will provide a unique opportunity for young scientists to share in the GRC experience. This two-day seminar will be organized by Graduate Students and Postdoctoral Fellows with the support of leading researchers, and will allow junior researchers within the field of plasminogen activation and extracellular proteolysis to come together to discuss their current research, while building informal networks with their peers that may lead to a lifetime of collaboration and scientific achievement.