Synaptic basis of motion detection in the retina
视网膜运动检测的突触基础
基本信息
- 批准号:8614797
- 负责人:
- 金额:$ 37.44万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-01-01 至 2018-12-31
- 项目状态:已结题
- 来源:
- 关键词:AcetylcholineAddressAmacrine CellsAreaBrainCellsChemicalsConsciousDataDendritesDetectionDevelopmentElectrophysiology (science)Eye MovementsFunctional disorderGeneticGoalsImageInterneuronsKnowledgeLabelLightMapsMotionMusNeuronsOutputProcessPropertyPublic HealthReportingResearchResolutionRetinaRetinalSensory ProcessStructureStructure-Activity RelationshipSynapsesSynaptic TransmissionTechniquesVaricosityVisionVisualVisual system structureWorkbasecell typecholinergiccholinergic synapsegamma-Aminobutyric Acidganglion cellinnovationinsightinterestneural circuitoptogeneticspatch clamppostsynapticpublic health relevanceresearch studyresponsesensory systemtooltransmission processvisual processvisual processing
项目摘要
Project Summary
Direction selective ganglion cells in the mammalian retina are strongly activated by motion in their preferred
direction, but are suppressed by motion in the opposite, or "null", direction. They report the direction of motion
to higher brain centers for further visual processing, and they contribute to the control of eye movements and,
potentially, to conscious vision. Direction selectivity of these ganglion cells is attributed to multiple pre- and
postsynaptic mechanisms. However, the implementation of these mechanisms at the synapse level is not fully
understood. The goal of this proposal is to provide fundamental insights into the structure-function relationship
of the synaptic circuitry that underlies direction selectivity. The proposed experiments will focus on synaptic
inputs from the starburst amacrine cell, a critical interneuron that co-releases GABA and acetylcholine onto
direction selective ganglion cells. We will first determine the properties of synaptic transmission and the
functional wiring diagrams of the GABAergic and cholinergic circuits from starburst amacrine cells to direction
selective ganglion cells, and will then identify the predominant synaptic mechanism underlying direction
selectivity. We will take an innovative approach that combines genetic cell type-specific targeting,
electrophysiology, fine resolution optogenetics and uncaging techniques to characterize and manipulate the
synapse types of interest, and to correlate synaptic-level mechanisms with circuit function. This work will
provide definitive answers to the outstanding questions that remain about the direction selective circuit. It will
also contribute to the knowledge of the general principles that govern sensory processing. Moreover, this
research will provide insight into the mechanism of chemical co-transmission in sensory systems and in higher
brain structures.
项目摘要
哺乳动物视网膜中的方向选择性神经节细胞在其优选的运动中被强烈激活。
方向上的运动,但被相反方向或“零”方向上的运动抑制。它们报告运动的方向
到更高级的大脑中心进行进一步的视觉处理,它们有助于控制眼球运动,
潜在地,到有意识的视觉。这些神经节细胞的方向选择性归因于多个前和
突触后机制然而,这些机制在突触水平上的实现并不完全。
明白该提案的目标是提供对结构-功能关系的基本见解
方向选择性背后的突触回路。拟议的实验将集中在突触
来自星状无长突细胞的输入,这是一种关键的中间神经元,它共同释放GABA和乙酰胆碱,
方向选择性神经节细胞我们将首先确定突触传递的性质和突触的性质。
从星爆无长突细胞到方向性的GABA能和胆碱能回路的功能布线图
选择性的神经节细胞,然后将确定主要的突触机制的方向
选择性我们将采取一种创新的方法,结合遗传细胞类型特异性靶向,
电生理学,精细分辨率光遗传学和uncaging技术,以表征和操纵
感兴趣的突触类型,并将突触水平机制与电路功能相关联。这项工作将
为关于方向选择电路的悬而未决的问题提供了明确的答案。它将
也有助于了解支配感觉处理的一般原则。而且这
研究将提供深入了解在感觉系统和更高的化学共传输机制,
大脑结构
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Wei Wei其他文献
Random sampling in shift invariant spaces
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10.1016/j.jmaa.2012.08.030 - 发表时间:
2013-02 - 期刊:
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Differential Protection for an Outgoing Transformer of Large-Scale Doubly Fed Induction Generator-Based Wind Farms
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10.3390/en7095566 - 发表时间:
2014-08 - 期刊:
- 影响因子:3.2
- 作者:
Bingtuan Gao;Wei Wei;Luoma Zhang;Ning Chen;Yingjun Wu;Yi Tang - 通讯作者:
Yi Tang
Wei Wei的其他文献
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- 资助金额:
$ 37.44万 - 项目类别:
Circuit mechanisms for encoding naturalistic motion in the mammalian retina
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10231126 - 财政年份:2018
- 资助金额:
$ 37.44万 - 项目类别:
Circuit mechanisms for encoding naturalistic motion in the mammalian retina
哺乳动物视网膜中编码自然运动的电路机制
- 批准号:
9788123 - 财政年份:2018
- 资助金额:
$ 37.44万 - 项目类别:
Synaptic basis of motion detection in the retina
视网膜运动检测的突触基础
- 批准号:
8788406 - 财政年份:2014
- 资助金额:
$ 37.44万 - 项目类别:
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