Caffeine Disposition After Inhalation

吸入后咖啡因的处置

• 批准号: 8636115
• 负责人: Steven Casey Laizure
• 金额: $ 7.5万
• 依托单位: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-15 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8636115
• 关键词: Address; Adverse effects; Alcohol abuse; Alcohol consumption; Alcoholic Intoxication; Alcohols; Attention; Behavioral; Beverages; Blood Pressure; Breathing; Caffeine; Cardiovascular system; Child; Coffee; Consumption; Data; Deposition; Devices; Dosage Forms; Dose; Drug Kinetics; Drunk driving; Epidemic; Exposure to; Goals; Heart Rate; Inhalation Drug Administration; Intoxication; Marketing; Measures; Methods; Moods; Oral; Oral Administration; Oral cavity; Pharmacodynamics; Phase; Physiological; Plasma; Powder dose form; Reporting; Risk; Shapes; Solutions; Tea; Testing; Time; Tube; United States Food and Drug Administration; Violence; absorption; alcohol effect; alcohol related problem; caffeine abuse; dietary supplements; drinking; high risk; insight; public health relevance; sexual assault; soft drink; volunteer; young adult

The co-abuse of energy drinks with alcohol has reached epidemic levels in young adults. This combination encourages heavy binge alcohol use, and is associated with an increase in alcohol- related problems including severe intoxication, violence, sexual assault, and drunk driving. This co-abuse of caffeine and alcohol coincides with the introduction of energy drinks that heralded the consumption of high caffeine content beverages in children and young adults, who prior to the availability of energy drinks had limited exposure to high caffeine levels. Recently, a new inhaled form of caffeine (Aeroshot") was introduced into the U.S. market as a dietary supplement and could expose young adults to even higher levels of caffeine posing an even greater risk of co-abuse with alcohol than energy drinks. Aeroshot" is a caffeine delivery device the size and shape of a lipstick case. By inhaling from one end of the tube a fine powder containing 100 mg of caffeine is deposited into the oral cavity and upper airway. How much and how fast caffeine gets into the body using this method of administration are unknown. These are critical questions, because the disposition of caffeine following administration especially during the crucial absorption phase is an important factor influencing abuse potential. Our overall hypothesis is that caffeine administration by inhalation results in more rapid absorption of caffeine and greater physiologic and behavioral effects than administration by oral solution. We plan to evaluate this hypothesis by completing specific aim 1) determine the plasma concentration-time profile of caffeine and its major metabolites after administration by oral solution and inhalation, and specific aim 2) determine the cardiovascular and mood effects of caffeine after administration by oral solution and inhalation. We expect the results from this study to provide important insight into the abuse potential of the Aeroshot" device alone and in combination with alcohol. Our long term goal is to define the pharmacodynamics of caffeine- alcohol abuse and the pharmacokinetic factors contributing to high-risk alcohol use in young adults.

能量饮料和酒精的共同滥用在年轻人中已经达到了流行的水平。这 这种组合会鼓励大量饮酒，并与酒精含量的增加有关。 相关问题包括严重醉酒、暴力、性侵犯和酒后驾车。 咖啡因和酒精的共同滥用与能量饮料的推出不谋而合，能量饮料 预示着儿童和年轻人对高咖啡因饮料的消费， 在能量饮料问世之前，接触高咖啡因的机会有限。最近，一位 新的吸入型咖啡因(Aeroshot)被引入美国市场，作为一种饮食 补充剂，并可能使年轻人接触到更高水平的咖啡因 与能量饮料相比，与酒精共滥用的风险更大。AeroShote“是一种咖啡因递送 设计口红盒的大小和形状。通过从试管的一端吸入细粉 含有100毫克咖啡因的咖啡因被沉积到口腔和上呼吸道。多少钱和 使用这种给药方法，咖啡因进入人体的速度尚不清楚。这些 都是关键问题，因为咖啡因在服药后的处置尤其重要 在关键的吸收阶段是影响滥用潜力的重要因素。我们的 总体假设是，吸入咖啡因会导致咖啡因更快地吸收 咖啡因和更大的生理和行为作用比口服溶液给药。我们 计划通过完成特定目标来评估此假设1)确定血浆 咖啡因及其主要代谢物口服给药后的药时曲线 溶液和吸入，以及特定的目标2)确定对心血管和情绪的影响 咖啡因口服液和吸入剂服用后。我们期待着由此产生的结果 这项研究为了解Aeroshot设备的滥用潜力提供了重要的见解 再加上酒精。我们的长期目标是确定咖啡因的药效学- 酒精滥用与青少年高危饮酒的药代动力学因素 成年人。