Caffeine Disposition After Inhalation

吸入后咖啡因的处置

• 批准号: 8847697
• 负责人: Steven Casey Laizure
• 金额: $ 7.39万
• 依托单位: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-15 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8847697
• 关键词: Address; Adverse effects; Alcohol abuse; Alcohol consumption; Alcoholic Intoxication; Alcohols; Attention; Behavioral; Beverages; Blood Pressure; Breathing; Caffeine; Cardiovascular system; Child; Coffee; Consumption; Data; Deposition; Devices; Dosage Forms; Dose; Drug Kinetics; Drunk driving; Epidemic; Exposure to; Goals; Health; Heart Rate; Inhalation Drug Administration; Intoxication; Marketing; Measures; Methods; Moods; Oral; Oral Administration; Oral cavity; Pharmacodynamics; Phase; Physiological; Plasma; Powder dose form; Reporting; Risk; Shapes; Solutions; Tea; Testing; Time; Tube; United States Food and Drug Administration; Violence; absorption; alcohol effect; alcohol related problem; caffeine abuse; dietary supplements; drinking; high risk; insight; sexual assault; soft drink; volunteer; young adult

DESCRIPTION (provided by applicant): The co-abuse of energy drinks with alcohol has reached epidemic levels in young adults. This combination encourages heavy binge alcohol use, and is associated with an increase in alcohol- related problems including severe intoxication, violence, sexual assault, and drunk driving. This co-abuse of caffeine and alcohol coincides with the introduction of energy drinks that heralded the consumption of high caffeine content beverages in children and young adults, who prior to the availability of energy drinks had limited exposure to high caffeine levels. Recently, a new inhaled form of caffeine (Aeroshot TM) was introduced into the U.S. market as a dietary supplement and could expose young adults to even higher levels of caffeine posing an even greater risk of co-abuse with alcohol than energy drinks. AeroshotTM is a caffeine delivery device the size and shape of a lipstick case. By inhaling from one end of the tube a fine powder containing 100 mg of caffeine is deposited into the oral cavity and upper airway. How much and how fast caffeine gets into the body using this method of administration are unknown. These are critical questions, because the disposition of caffeine following administration especially during the crucial absorption phase is an important factor influencing abuse potential. Our overall hypothesis is that caffeine administration by inhalation results in more rapid absorption of caffeine and greater physiologic and behavioral effects than administration by oral solution. We plan to evaluate this hypothesis by completing specific aim 1) determine the plasma concentration-time profile of caffeine and its major metabolites after administration by oral solution and inhalation, and specific aim 2) determine the cardiovascular and mood effects of caffeine after administration by oral solution and inhalation. We expect the results from this study to provide important insight into the abuse potential of the AeroshotTM device alone and in combination with alcohol. Our long term goal is to define the pharmacodynamics of caffeine- alcohol abuse and the pharmacokinetic factors contributing to high-risk alcohol use in young adults.

描述（由申请人提供）：能量饮料与酒精的共同滥用在年轻人中已达到流行水平。这种结合鼓励重度酗酒，并与酒精相关问题的增加有关，包括严重中毒，暴力，性侵犯和酒后驾车。咖啡因和酒精的共同滥用与能量饮料的引入相吻合，这预示着儿童和年轻人消费高咖啡因含量的饮料，在能量饮料可用之前，他们接触高咖啡因水平有限。最近，一种新的吸入形式的咖啡因（Aeroshot TM）被引入美国市场作为膳食补充剂，并可能使年轻人暴露于更高水平的咖啡因，造成与酒精共同滥用的风险比能量饮料更大。AeroshotTM是一种咖啡因输送装置，其大小和形状与口红盒相仿。通过从管的一端吸入，含有100毫克咖啡因的细粉末沉积到口腔和上气道中。使用这种给药方法，咖啡因进入体内的量和速度尚不清楚。这些都是关键问题，因为咖啡因在给药后的处置，特别是在关键的吸收阶段，是影响滥用潜力的重要因素。我们的总体假设是，通过吸入给予咖啡因比通过口服溶液给药导致咖啡因更快的吸收和更大的生理和行为效应。我们计划通过完成特定目标1）确定口服溶液和吸入给药后咖啡因及其主要代谢物的血浆浓度-时间曲线，以及特定目标2）确定口服溶液和吸入给药后咖啡因的心血管和情绪效应来评估这一假设。我们希望本研究的结果能够为AeroshotTM器械单独使用以及与酒精联合使用的滥用潜力提供重要见解。我们的长期目标是确定咖啡因-酒精滥用的药效学和导致年轻人高危酒精使用的药代动力学因素。

项目成果

Measurement of caffeine and its three primary metabolites in human plasma by HPLC-ESI-MS/MS and clinical application.

• DOI: 10.1002/bmc.3900
• 发表时间: 2017-06
• 期刊: Biomedical chromatography : BMC
• 作者: Chen F;Hu ZY;Parker RB;Laizure SC
• 通讯作者: Laizure SC

Comparison of caffeine disposition following administration by oral solution (energy drink) and inspired powder (AeroShot) in human subjects.

人类受试者口服溶液（能量饮料）和激发粉末（AeroShot）后咖啡因处置的比较。

• DOI: 10.1111/bcp.13389
• 发表时间: 2017
• 期刊: British journal of clinical pharmacology
• 影响因子: 3.4
• 作者: Laizure,SCasey;Meibohm,Bernd;Nelson,Kembral;Chen,Feng;Hu,Zhe-Yi;Parker,RobertB
• 通讯作者: Parker,RobertB