Investigating the action of clozapine on the epidermal growth factor system: implications for antipsychotic drug action

研究氯氮平对表皮生长因子系统的作用：对抗精神病药物作用的影响

• 批准号: nhmrc : 628802
• 负责人: A/Pr Peter Crouch
• 金额: $ 24.31万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-action-clozapine-drug-action/95884
• 关键词: Investigating; action; clozapine; epidermal; growth

Current treatments for schizophrenia are ineffective for up to half of sufferers leaving the toxic drug clozapine as the only resort. This project aims to investigate if the unique effectiveness of clozapine is due to a novel action in brain cells that we have identified. The project will delineate this mechanism and from this may lead to the development of a new way of treating schizophrenia and insights into the causes of this disorder.

目前精神分裂症的治疗方法对多达一半的患者无效，留下有毒药物氯氮平作为唯一的手段。这个项目的目的是调查，如果氯氮平的独特效果是由于一个新的行动，我们已经确定的脑细胞。该项目将描述这种机制，并由此可能导致开发一种治疗精神分裂症的新方法，并深入了解这种疾病的原因。