Harnessing the consequences of impaired mitochondrial function to treat and image motor neuron disease

利用线粒体功能受损的后果来治疗和成像运动神经元疾病

• 批准号: nhmrc : 1084927
• 负责人: A/Pr Peter Crouch
• 金额: $ 31.57万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/harnessing-consequences-impaired-neuron-disease/519043
• 关键词: Harnessing; consequences; impaired; mitochondrial; function

Motor neuron disease (MND) is a group of fatal adult-onset diseases affecting the neurons that relay signals from the brain to muscles. The incidence of MND is rapidly increasing due to the ageing population and a diagnosis of MND comes with a prognosis of paralysis and 2-5 years survival. The diagnosis process is lengthy, and even after MND is confirmed, there are no effective therapeutics. This research project aims to develop new therapeutic and diagnostic options for MND.

运动神经元病（MND）是一组致命的成人发病性疾病，影响从大脑到肌肉传递信号的神经元。由于人口老龄化，MND的发病率迅速增加，并且MND的诊断伴随瘫痪和2-5年生存的预后。诊断过程是漫长的，即使在MND被确认后，也没有有效的治疗方法。该研究项目旨在为MND开发新的治疗和诊断选择。