Gene-environment interactions modulating cognition and dementia in Huntington’s disease

基因-环境相互作用调节亨廷顿病的认知和痴呆

• 批准号: nhmrc : GNT1085977
• 负责人: A/Pr Peter Crouch
• 金额: $ 43.88万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/gene-environment-interactions-huntingtons-disease/1345643
• 关键词: Gene; environment; interactions; modulating; cognition

We are investigating mechanisms whereby cognitive symptoms, culminating in dementia, occur in a fatal brain disease, Huntington’s. We will explore how the ‘genetic stutter’ affects the brain at the level of molecules and cells, which will help identify targets for future treatment. We will also establish how environmental factors, including cognitive stimulation, physical activity and stress, modulate dementia. This will inform the development of treatments for this currently incurable disease.

我们正在研究一种致命的脑部疾病--亨廷顿舞蹈症--的认知症状，最终导致痴呆的机制。我们将探索“遗传口吃”如何在分子和细胞水平上影响大脑，这将有助于确定未来治疗的目标。我们还将确定环境因素，包括认知刺激，体力活动和压力，如何调节痴呆症。这将为这种目前无法治愈的疾病的治疗提供信息。