Image-guided planning system for skull correction in children with craniosynostos

颅缝早闭儿童颅骨矫正的图像引导规划系统

• 批准号: 8778815
• 负责人: Andinet Asmamaw Enquobahrie
• 金额: $ 22.48万
• 依托单位: KITWARE, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-26 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8778815
• 关键词: Address; Adult; Aftercare; Age; Algorithms; Area; Atlases; Biomechanics; Brain; Cephalic; Child; Clinical; Clinical Trials; Clinical assessments; Collaborations; Complex; Computer software; Craniosynostosis; Data; Databases; Development; Ethnic Origin; Evaluation; Goals; Growth; Head; Helmet; Hemorrhage; Hospitals; Image; Image Analysis; Impairment; Individual; Infant; Institution; Intervention; Jaw; Joint structure of suture of skull; Lead; Live Birth; Machine Learning; Maps; Measurement; Medical Imaging; Medical center; Methods; Molds; Morbidity - disease rate; Morphology; Operative Surgical Procedures; Osteotomy; Outcome; Patients; Pediatric Research; Perioperative; Phase; Planning Techniques; Postoperative Period; Property; Reconstructive Surgical Procedures; Reproducibility; Research; Research Personnel; Shapes; Simulate; Small Business Technology Transfer Research; Surgeon; System; Techniques; Technology; Testing; Time; Translations; Treatment Cost; Variant; Visual; Work; X-Ray Computed Tomography; age group; base; bone; clinical application; clinical practice; commercialization; common treatment; craniofacial; cranium; design; experience; graphical user interface; image processing; improved; innovation; interest; malformation; premature; pressure; public health relevance; reconstruction; research and development; shape analysis; success; tool; treatment planning; virtual

DESCRIPTION (provided by applicant): Craniosynostosis is the premature fusion of cranial sutures and occurs in approximately one in 2000 live births. It results in cranial malformation that can lead to elevated intra-cranial pressure, brain growth impairment, and developmental deficiency. The most common treatment option for craniosynostosis is surgery. Currently, surgical treatment planning of craniosynostosis is mostly qualitative, subjective and irreproducible guided mainly by the surgeon's experience. While virtual planning has been successfully introduced in niche areas of craniofacial surgery, such as corrective jaw surgery applications, clinical tools that provide accurate and reproducible evaluation of cranial morphology to guide cranial vault remodeling do not yet exist. To cover this gap in current clinical practice, we will develop personalized preoperative planning for infants with craniosynostosis that allows for decreased operative time and blood loss, thereby reducing perioperative morbidity, but also facilitates an optimized and more durable long-term outcome. In this Phase I STTR project, our goal is to design, develop and validate a virtual surgery system for optimal treatment planning for cranial remodeling. The plan includes creating a normative multi-atlas database to capture a wide breadth of normal variations on cranial shape and patient ages, developing image processing and statistical shape analysis algorithms to identify desirable post-operative skull shapes, and analyzing biomechanical properties of cranial bones to evaluate osteotomy plans. The surgeon will be presented with a visual and quantitative map of the patient's cranial malformations, the desired post-treatment cranial shape, and a personalized plan of how cranial shape should be altered in the least invasive fashion to most accurately approach the normal head shape. The impact of our technology is reduced perioperative morbidity and lower treatment costs. The technology will also enable the precise, quantitative comparison of measurements before and after cranial vault reconstruction to determine the efficacy and durability of specific reconstructive techniques.

描述（由申请人提供）：颅突式症是颅骨缝合线的过早融合，发生在2000年的活产中。它会导致颅骨畸形，从而导致颅内压，大脑生长障碍和发育缺陷升高。颅突式症的最常见治疗选择是手术。目前，颅突的手术治疗计划主要是由外科医生的经验引导的定性，主观和不可培养的。虽然虚拟计划已在颅面手术的利基领域成功引入，例如矫正下颌手术应用，但临床工具可提供对颅形态的准确评估，以指导颅拱顶重塑，但尚不存在。为了弥补当前临床实践中的这一差距，我们将针对患有颅内脑流​​行病的婴儿制定个性化的术前计划，从而减少手术时间和失血，从而降低围手术期的发病率，但也促进了优化且更耐用的长期结果。 在此阶段I STTR项目中，我们的目标是设计，开发和验证虚拟手术系统，以最佳的颅骨改造计划。该计划包括创建一个规范性的多ATLA数据库，以捕获颅面和患者年龄的正常变化的广泛范围，开发图像处理和统计形状分析算法，以识别所需的术后头骨形状，并分析颅骨的生物力学特性以评估骨质瘤计划。将向外科医生提供有关患者颅骨畸形，所需的治疗后颅骨形状的视觉和定量图，以及如何以最小的侵入性方式改变颅骨形状的个性化计划，以最准确地接近正常的头部形状。我们技术的影响是围手术期发病率降低和降低治疗成本。该技术还将实现颅库重建前后测量值的精确，定量的比较，以确定特定重建技术的功效和耐用性。

项目成果

Personalized Optimal Planning for the Surgical Correction of Metopic Craniosynostosis.

异位颅缝早闭手术矫正的个性化最佳规划。

• DOI: 10.1007/978-3-319-46472-5_8
• 发表时间: 2016
• 期刊: Clinical image-based procedures : from planning to intervention : international workshop, CLIP ..., held in conjunction with MICCAI ... : revised selected papers. CLIP (Workshop)
• 作者: Porras,AntonioR;Zukic,D;Equobahrie,A;Rogers,GaryF;Linguraru,MariusGeorge
• 通讯作者: Linguraru,MariusGeorge

Osteotomy Planner: An open-source tool for osteotomy simulation.

Osteotomy Planner：用于截骨模拟的开源工具。

• DOI: 10.1117/12.2293649
• 发表时间: 2018
• 期刊: Proceedings of SPIE--the International Society for Optical Engineering
• 作者: Horvath,Sam;Paniagua,Beatriz;Andruejol,Johan;Porras,AntonioR;Linguraru,MariusGeorge;Enquobahrie,Andinet
• 通讯作者: Enquobahrie,Andinet