Image-guided planning system for skull correction in children with craniosynostos

颅缝早闭儿童颅骨矫正的图像引导规划系统

• 批准号: 8778815
• 负责人: Andinet Asmamaw Enquobahrie
• 金额: $ 22.48万
• 依托单位: KITWARE, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-26 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8778815
• 关键词: Address; Adult; Aftercare; Age; Algorithms; Area; Atlases; Biomechanics; Brain; Cephalic; Child; Clinical; Clinical Trials; Clinical assessments; Collaborations; Complex; Computer software; Craniosynostosis; Data; Databases; Development; Ethnic Origin; Evaluation; Goals; Growth; Head; Helmet; Hemorrhage; Hospitals; Image; Image Analysis; Impairment; Individual; Infant; Institution; Intervention; Jaw; Joint structure of suture of skull; Lead; Live Birth; Machine Learning; Maps; Measurement; Medical Imaging; Medical center; Methods; Molds; Morbidity - disease rate; Morphology; Operative Surgical Procedures; Osteotomy; Outcome; Patients; Pediatric Research; Perioperative; Phase; Planning Techniques; Postoperative Period; Property; Reconstructive Surgical Procedures; Reproducibility; Research; Research Personnel; Shapes; Simulate; Small Business Technology Transfer Research; Surgeon; System; Techniques; Technology; Testing; Time; Translations; Treatment Cost; Variant; Visual; Work; X-Ray Computed Tomography; age group; base; bone; clinical application; clinical practice; commercialization; common treatment; craniofacial; cranium; design; experience; graphical user interface; image processing; improved; innovation; interest; malformation; premature; pressure; public health relevance; reconstruction; research and development; shape analysis; success; tool; treatment planning; virtual

DESCRIPTION (provided by applicant): Craniosynostosis is the premature fusion of cranial sutures and occurs in approximately one in 2000 live births. It results in cranial malformation that can lead to elevated intra-cranial pressure, brain growth impairment, and developmental deficiency. The most common treatment option for craniosynostosis is surgery. Currently, surgical treatment planning of craniosynostosis is mostly qualitative, subjective and irreproducible guided mainly by the surgeon's experience. While virtual planning has been successfully introduced in niche areas of craniofacial surgery, such as corrective jaw surgery applications, clinical tools that provide accurate and reproducible evaluation of cranial morphology to guide cranial vault remodeling do not yet exist. To cover this gap in current clinical practice, we will develop personalized preoperative planning for infants with craniosynostosis that allows for decreased operative time and blood loss, thereby reducing perioperative morbidity, but also facilitates an optimized and more durable long-term outcome. In this Phase I STTR project, our goal is to design, develop and validate a virtual surgery system for optimal treatment planning for cranial remodeling. The plan includes creating a normative multi-atlas database to capture a wide breadth of normal variations on cranial shape and patient ages, developing image processing and statistical shape analysis algorithms to identify desirable post-operative skull shapes, and analyzing biomechanical properties of cranial bones to evaluate osteotomy plans. The surgeon will be presented with a visual and quantitative map of the patient's cranial malformations, the desired post-treatment cranial shape, and a personalized plan of how cranial shape should be altered in the least invasive fashion to most accurately approach the normal head shape. The impact of our technology is reduced perioperative morbidity and lower treatment costs. The technology will also enable the precise, quantitative comparison of measurements before and after cranial vault reconstruction to determine the efficacy and durability of specific reconstructive techniques.

描述（由申请方提供）：颅缝早闭是颅缝过早融合，发生率约为1/2000活产。它导致颅骨畸形，可导致颅内压升高，脑生长障碍和发育缺陷。颅缝早闭最常见的治疗选择是手术。目前，颅缝早闭的手术治疗计划大多是定性的，主观的和不可重复的主要由外科医生的经验指导。虽然虚拟计划已成功引入颅面外科的利基领域，如矫正颌外科应用，但提供准确和可重复的颅骨形态评估以指导颅穹窿重塑的临床工具尚不存在。为了弥补目前临床实践中的这一差距，我们将为颅缝早闭婴儿制定个性化的术前计划，以减少手术时间和失血量，从而降低围手术期发病率，同时促进优化和更持久的长期结局。 在这个一期STTR项目中，我们的目标是设计，开发和验证一个虚拟手术系统，用于颅骨重塑的最佳治疗计划。该计划包括创建一个规范的多图谱数据库，以捕获颅骨形状和患者年龄的广泛正常变化，开发图像处理和统计形状分析算法，以识别理想的术后颅骨形状，并分析颅骨的生物力学特性，以评估截骨计划。将向外科医生提供患者颅骨畸形的视觉和定量图、所需的治疗后颅骨形状以及如何以最小侵入性方式改变颅骨形状以最准确地接近正常头部形状的个性化计划。我们的技术的影响是降低围手术期发病率和降低治疗成本。该技术还将能够对颅顶重建前后的测量结果进行精确、定量的比较，以确定特定重建技术的有效性和耐用性。

项目成果

Personalized Optimal Planning for the Surgical Correction of Metopic Craniosynostosis.

异位颅缝早闭手术矫正的个性化最佳规划。

• DOI: 10.1007/978-3-319-46472-5_8
• 发表时间: 2016
• 期刊: Clinical image-based procedures : from planning to intervention : international workshop, CLIP ..., held in conjunction with MICCAI ... : revised selected papers. CLIP (Workshop)
• 作者: Porras,AntonioR;Zukic,D;Equobahrie,A;Rogers,GaryF;Linguraru,MariusGeorge
• 通讯作者: Linguraru,MariusGeorge

Osteotomy Planner: An open-source tool for osteotomy simulation.

Osteotomy Planner：用于截骨模拟的开源工具。

• DOI: 10.1117/12.2293649
• 发表时间: 2018
• 期刊: Proceedings of SPIE--the International Society for Optical Engineering
• 作者: Horvath,Sam;Paniagua,Beatriz;Andruejol,Johan;Porras,AntonioR;Linguraru,MariusGeorge;Enquobahrie,Andinet
• 通讯作者: Enquobahrie,Andinet