Racial disparities in cancer outcomes: quantifying modifiable mechanisms
癌症结果的种族差异:量化可修改的机制
基本信息
- 批准号:8721744
- 负责人:
- 金额:$ 12.64万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-09-11 至 2017-08-31
- 项目状态:已结题
- 来源:
- 关键词:AccountingAddressAdultAfrican AmericanAreaAwardBiologic CharacteristicBiological AssayBiologyCancer BiologyCancer BurdenCancer ControlCase-Control StudiesCentral obesityCessation of lifeChildhoodClinicalCommunitiesCountyDataDiagnosisEnrollmentEpidemiologic MethodsEpidemiologyGenderGeneral PopulationGoalsGrantIncidenceInequalityInterventionLeadMalignant NeoplasmsMediationMentorsMethodsModelingMorbidity - disease rateNorth CarolinaObesityOutcomePathway interactionsPolicy MakerPopulationPopulation ControlPremenopauseProcessPublic HealthRelative (related person)ResearchRiskSocioeconomic StatusStructural ModelsTechniquesTrainingTreatment EfficacyWeightWeight GainWomanWorkbasecancer diagnosiscancer health disparitycancer preventioncancer riskcohorteffective interventionepidemiologic dataethnic minority populationfollow-uphealth disparityhigh riskimprovedinnovationlow socioeconomic statusmalignant breast neoplasmmenmolecular markermortalitynoveloutcome forecastpopulation basedracial and ethnicracial and ethnic disparitiesracial differenceskillssocioeconomicssymposiumtumor
项目摘要
DESCRIPTION (provided by applicant): This proposal addresses a central challenge in cancer prevention and control: prioritizing efforts to reduce cancer disparities. Some racial and socioeconomic groups have higher rates of cancer incidence and mortality than others. However, the processes causing these disparities remain unclear. Standard epidemiologic methods describe cancer disparities but do not identify the causes of the disparities. To effectively intervene to reduce disparities, we must identify the mechanisms by which disparities arise. This grant will train the recipient to identify modifiable causes of disparities in cancer incidence and mortality using epidemiologic data. To develop the necessary statistical and substantive expertise, the recipient will receive training in three areas: (1) novel statistical techniques that are specifically suited to dissect health disparities (i.e., econometric decomposition and causal mediation analysis using marginal structural models); (2) mentored application of the statistical techniques in a racially and socioeconomically diverse cohort of U.S. men and women; and (3) biological characteristics of tumors that predict prognosis and treatment efficacy. This training will be achieved via hands-on mentored research, coursework, and limited conference attendance. Using the skills developed through the training, the grant recipient will specifically investigate causes of higher breast cancer burden in Black versus White women in the U.S. Socioeconomic status is believed to account for a large portion of racial disparities in breast cancer risk and mortality, but it is unclear by what specific pathways
SES influences these racial disparities. This research will estimate the contribution of one pathway by which low SES contributes to racial cancer disparities in breast cancer risk, biology, and mortality: adult weight gain and obesity. The research uses data from the Carolina Breast Cancer Study, a population-based, case-control study conducted in 24 counties of North Carolina. Women with invasive breast cancer and population controls were enrolled between 1993 and 2011. The data consist of 1,803 cases of invasive breast cancer (787 African- American, 1,016 white) and 1,564 population-based controls (718 African- American, 846 white). A unique strength of the data is novel molecular markers of breast cancer subtypes. These markers will allow the study to quantify a potential causal pathway underlying the higher risk of the basal-like subtype of breast cancer in Black women. The results of this work will help policy-makers and the public health and clinical communities evaluate what interventions will be most effective in reducing cancer disparities.
描述(由申请人提供):本提案解决了癌症预防和控制的核心挑战:优先努力减少癌症差异。一些种族和社会经济群体的癌症发病率和死亡率高于其他群体。然而,造成这些差异的过程仍不清楚。标准流行病学方法描述了癌症差异,但没有确定差异的原因。为了有效地进行干预以减少差距,我们必须确定产生差距的机制。这笔赠款将培训受助人利用流行病学数据确定癌症发病率和死亡率差异的可修改原因。为了发展必要的统计和实质性专门知识,接受者将在三个领域接受培训:(1)特别适合剖析健康差异的新颖统计技术(即使用边际结构模型的计量经济分解和因果中介分析);(2)指导统计技术在种族和社会经济多样化的美国男性和女性队列中的应用;(3)预测预后和治疗效果的肿瘤生物学特性。该培训将通过实践指导的研究、课程作业和有限的会议出席来实现。利用通过培训培养的技能,赠款接受者将专门调查美国黑人与白人女性乳腺癌负担较高的原因。社会经济地位被认为是导致乳腺癌风险和死亡率的很大一部分种族差异的原因,但具体途径尚不清楚
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Whitney Ragan Robinson其他文献
Whitney Ragan Robinson的其他文献
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{{ truncateString('Whitney Ragan Robinson', 18)}}的其他基金
Racial Differences in Treatment with Hysterectomy: a Multilevel Investigation
子宫切除术治疗的种族差异:多层次调查
- 批准号:
10588401 - 财政年份:2017
- 资助金额:
$ 12.64万 - 项目类别:
Racial Differences in Treatment with Hysterectomy: a Multilevel Investigation
子宫切除术治疗的种族差异:多层次调查
- 批准号:
10196944 - 财政年份:2017
- 资助金额:
$ 12.64万 - 项目类别:
Racial Differences in Treatment with Hysterectomy: a Multilevel Investigation
子宫切除术治疗的种族差异:多层次调查
- 批准号:
9381334 - 财政年份:2017
- 资助金额:
$ 12.64万 - 项目类别:
Racial disparities in cancer outcomes: quantifying modifiable mechanisms
癌症结果的种族差异:量化可修改的机制
- 批准号:
8425259 - 财政年份:2012
- 资助金额:
$ 12.64万 - 项目类别:
Racial disparities in cancer outcomes: quantifying modifiable mechanisms
癌症结果的种族差异:量化可修改的机制
- 批准号:
9124796 - 财政年份:2012
- 资助金额:
$ 12.64万 - 项目类别:
Racial disparities in cancer outcomes: quantifying modifiable mechanisms
癌症结果的种族差异:量化可修改的机制
- 批准号:
8544184 - 财政年份:2012
- 资助金额:
$ 12.64万 - 项目类别:
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