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Recombinant Vaccines for Prevention of AIDS and Other Diseases

Recombinant Vaccines for Prevention of AIDS and Other Diseases
用于预防艾滋病和其他疾病的重组疫苗
批准号：
8946263
负责人：
Bernard Moss
金额：
$56.55万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8946263
关键词：
AIDS preventionAdverse effectsAnimalsAntigensCellular ImmunityDNA VaccinesDiseaseHIV vaccineLifePhase I Clinical TrialsPoxviridaeRecombinant ProteinsRecombinant VaccinesResearchTestingVaccinesVaccinia virusViralViral AntigensWorkimprovednonhuman primaterecombinant virus vaccinevaccine candidatevector

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中文摘要
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英文摘要
There are many diseases for which there are no vaccines and others for which the vaccines are not optimal or have significant side effects. The objectives of this project are to characterize viral antigens, determine targets of humoral and cell mediated immunity, and use this information to develop candidate vaccines. Live recombinant viral vaccines, DNA vaccines and recombinant protein vaccines are being developed. Presently we are working on vaccinia virus-vectored vaccines for HIV. The vaccines are first tested in small animals and then in non-human primates. Phase 1 clinical trials are ongoing by collaborators.
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会议论文
Poxvirus pathogenesis and immunity
Poxvirus Assembly
Poxvirus DNA Replication
Poxvirus Gene Expression
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