Recombinant Vaccines for Prevention of AIDS and Other Diseases

用于预防艾滋病和其他疾病的重组疫苗

• 批准号: 8156837
• 负责人: Bernard Moss
• 金额: $ 86.16万
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8156837
• 关键词: AIDS prevention; Disease; Recombinant Vaccines

There are many diseases for which there are no vaccines and others for which the vaccines are not optimal or have significant side effects. The objectives of this project are to characterize viral antigens, determine targets of humoral and cell mediated immunity, and use this information to develop candidate vaccines. Live recombinant viral vaccines, DNA vaccines and recombinant protein vaccines are being developed. The vaccines are first tested in small animals and then in non-human primates. Presently we are working on vaccines for HIV.

有许多疾病没有疫苗，而另一些疾病的疫苗不是最佳的或有明显的副作用。 该项目的目标是描述病毒抗原的特征，确定体液和细胞介导免疫的靶点，并利用这些信息开发候选疫苗。重组病毒活疫苗、DNA疫苗和重组蛋白疫苗正在开发中。这些疫苗首先在小动物身上进行测试，然后在非人类灵长类动物身上进行测试。目前，我们正在研制艾滋病毒疫苗。