Preventing Inter-generational Transmission of Obesity and Cardiometabolic Risk
预防肥胖和心脏代谢风险的代际传播
基本信息
- 批准号:8708201
- 负责人:
- 金额:$ 63.05万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-08-01 至 2018-07-31
- 项目状态:已结题
- 来源:
- 关键词:4 year oldAddressAffectAgeAnimal ModelAutonomic nervous systemBackBirthCardiovascular systemCell physiologyChildClinicalControl GroupsDataDevelopmentDietDiseaseDisease susceptibilityEatingEnvironmentEpidemiologyEvaluationHealthHumanHydrocortisoneHyperactive behaviorIndividualInfantInsulin ResistanceInterventionIntervention TrialKnowledgeLeadLifeMalnutritionMetabolicMetabolic DiseasesMothersNewborn InfantObesityOrganismOutcomePathway interactionsPhysiologicalPilot ProjectsPlayPopulationPregnancyPrevalencePreventionPrimary PreventionProcessRegulationRelative (related person)ResearchRiskRisk FactorsRoleSamplingSinus ArrhythmiaSocietiesStressStructureSumSystemTestingTimeTissuesTreatment EfficacyVariantWeightWeight GainWomanbody systemburden of illnesscardiovascular disorder riskcardiovascular risk factorcontrol trialdisorder riskefficacy testingfetalfollow-upgroup interventionimprovedin uteroindexingintergenerationalintervention effectmaternal stressneurobehavioralnoveloffspringpostnatalprenatalprenatal interventionprenatal stresspreventprogramspublic health relevancerespiratorytransmission process
项目摘要
DESCRIPTION (provided by applicant): Effective primary prevention requires knowledge of modifiable antecedents of disease risk. Obesity, autonomic dysregulation, and HPA axis dysregulation are risk factors for cardiovascular and metabolic (cardiometabolic) disorders. Their prevalence in populations of all ages is increasing, including among young children. Converging evidence traces the origins of cardiometabolic risk back to the intrauterine and early postnatal period of life, supporting the concept of developmental programming of health and disease. Maternal excess weight and excess stress exposure are emerging as important gestational environment factors that affect offspring development and are plausible contributors to later disease. Previous research has been primarily cross-sectional or retrospective and/or has assessed limited systems for prenatal effects. The proposed research expands this research by capitalizing on an existing control trial of a prenatal intervention to reduce maternal
stress and excessive weight gain during gestation to examine the effects of intrauterine exposures on subsequent child cardiometabolic risk. We propose to follow 168 offspring of women in the trial from birth until 4 years age, with longitudinal assessments of cardiometabolic risk factors (adiposity, autonomic and HPA axis dysregulation) and their developmental trajectories. We will evaluate the effects of the intervention (Aim 1), as well as the effects of individual-level variation in prenatal stress and weight gain (Aim 2), on newborn and child outcomes that are likely early drivers of cardiovascular disease risk. The span of assessments allows us to separate the effects of prenatal from postnatal influences and examine important developmental trajectories; and assessment of other exposures will reduce confounding and provide clues about pathways and further targets of intervention. Preliminary data from the prenatal intervention suggest it reduces stress and weight gain in mothers and data from our offspring pilot study provide initial support for our hypotheses, showing maternal improvements in stress and weight gain predicted improved indices of offspring adiposity and neurobehavioral regulation. The SPECIFIC AIMS are to: 1) Test whether offspring born to mothers in the intervention have more favorable cardiometabolic outcomes (lower levels of: adiposity, autonomic dysregulation, and HPA-axis dysregulation) at birth and over the first 4 years of life, relative to offspring in the control group. 2) Examine across the full sample of 168 mother-infant dyads (controlling for treatment group) whether: a) Cardiometabolic risk outcomes, at birth and over the first 4 years of life, are more adverse in offspring from mothers with greater adiposity and/or stress during pregnancy. b) Adverse cardiometabolic outcomes are heightened in offspring from mothers with higher levels of both weight and stress (synergistic effects). Animal models provide support for such associations, but this interactive effect on offspring cardiometabolic risk outcomes has not yet been tested in human studies.
描述(由申请人提供):有效的一级预防需要了解疾病风险的可变前因。肥胖、自主神经失调和HPA轴失调是心血管和代谢(心脏代谢)疾病的危险因素。在所有年龄段的人群中,包括在幼儿中,它们的患病率都在上升。越来越多的证据表明,心脏代谢风险的起源可以追溯到子宫内和出生后早期,这支持了健康和疾病发展规划的概念。母亲超重和过度的压力暴露正在成为影响后代发育的重要妊娠环境因素,并可能导致后代患病。以前的研究主要是横断面或回顾性和/或评估有限的产前影响系统。拟议的研究扩大了这项研究,利用现有的产前干预的对照试验,以减少产妇
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Nicole Renee Bush其他文献
Nicole Renee Bush的其他文献
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{{ truncateString('Nicole Renee Bush', 18)}}的其他基金
Retaining the diverse CANDLE cohort to advance ECHO Cohort solution-oriented research and identify early-life modifiable risk factors for obesity and mental health problems in children
保留多样化的 CANDLE 队列,以推进 ECHO 队列以解决方案为导向的研究,并确定儿童肥胖和心理健康问题的早期可改变风险因素
- 批准号:
10745100 - 财政年份:2023
- 资助金额:
$ 63.05万 - 项目类别:
Prenatal and Early Childhood Pathways To Health: An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory Outcomes
产前和幼儿期健康之路:化学和社会暴露、生物机制以及对神经发育和呼吸结果的性别特异性影响的综合模型
- 批准号:
9262422 - 财政年份:2016
- 资助金额:
$ 63.05万 - 项目类别:
Prenatal and Early Childhood Pathways To Health: An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory Outcomes
产前和幼儿期健康之路:化学和社会暴露、生物机制以及对神经发育和呼吸结果的性别特异性影响的综合模型
- 批准号:
9355741 - 财政年份:2016
- 资助金额:
$ 63.05万 - 项目类别:
Prenatal and Early Childhood Pathways To Health: An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory Outcomes
产前和幼儿期健康之路:化学和社会暴露、生物机制以及对神经发育和呼吸结果的性别特异性影响的综合模型
- 批准号:
10018122 - 财政年份:2016
- 资助金额:
$ 63.05万 - 项目类别:
Prenatal and Early Childhood Pathways To Health: An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory Outcomes
产前和幼儿期健康之路:化学和社会暴露、生物机制以及对神经发育和呼吸结果的性别特异性影响的综合模型
- 批准号:
10241431 - 财政年份:2016
- 资助金额:
$ 63.05万 - 项目类别:
Prenatal and Early Childhood Pathways To Health: An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory Outcomes
产前和幼儿期健康之路:化学和社会暴露、生物机制以及对神经发育和呼吸结果的性别特异性影响的综合模型
- 批准号:
10473537 - 财政年份:2016
- 资助金额:
$ 63.05万 - 项目类别:
Prenatal and Early Childhood Pathways To Health: An Integrated Model of Chemical and Social
产前和幼儿健康之路:化学和社会的综合模型
- 批准号:
10205408 - 财政年份:2016
- 资助金额:
$ 63.05万 - 项目类别:
Preventing Inter-generational Transmission of Obesity and Cardiometabolic Risk
预防肥胖和心脏代谢风险的代际传播
- 批准号:
9119029 - 财政年份:2013
- 资助金额:
$ 63.05万 - 项目类别:
Preventing Inter-generational Transmission of Obesity and Cardiometabolic Risk
预防肥胖和心脏代谢风险的代际传播
- 批准号:
8528402 - 财政年份:2013
- 资助金额:
$ 63.05万 - 项目类别:
Preventing Inter-generational Transmission of Obesity and Cardiometabolic Risk
预防肥胖和心脏代谢风险的代际传播
- 批准号:
9314614 - 财政年份:2013
- 资助金额:
$ 63.05万 - 项目类别:
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