Developmental and Translational Pharmacology of Pediatric Antimicrobial Therapy

描述（由申请人提供）：该项目名为“儿科抗菌药物治疗的发展和转化药理学”，是根据RFA-HD-10-026：儿科发展药理学研究专业中心（RPDP）项目（U54）提交的申请。加州大学圣地亚哥分校拟议项目的总体主题是汇集发育生理学、药理学和传染病领域的非临床和临床专家，并进行转化研究，以推进儿科发育药理学领域的发展。本项目由3个主要项目组成；2个试点项目和4个核心。三个主要项目是“colistimeate在婴儿和儿童中的剂量优化”，“药物与内源性抗生素的药物-药物相互作用”和“发育方面”

DESCRIPTION (provided by applicant): This program, entitled "Developmental and Translational Pharmacology of Pediatric Antimicrobial Therapy", is submitted as an application responsive to RFA-HD-10-026: Specialized Center in Research in Pediatric Developmental Pharmacology (RPDP) Program (U54). The overall theme of the proposed program at the UC San Diego is to bring together non-clinical and clinical experts in the fields of developmental physiology, pharmacology, and infectious diseases and conduct translational research to advance the field of pediatric developmental pharmacology. This program is comprised of 3 Main Projects; 2 Pilot Projects and 4 Cores. The three main projects are "Colistimethate Dose Optimization in Infants and Children", "Drug-Drug Interactions between Pharmaceutical and Endogenous Antibiotics" and "Developmental Aspects of Aminopenicillin Renal Clearance". Each project utilizes the Administrative Core (A), the Pharmacometrics Core (B), the Quantitative Pharmacology Assay Core (C) and the Training and Outreach Core (D). Working together these projects and cores will characterize developmental changes in the disposition and potential toxicity of antimicrobial therapy. The program will capitalize on the discoveries made in basic science laboratories at UC Diego and extend these investigations in both non-clinical and clinical domains. The Cores will develop pharmacologic assays that are appropriate across the pediatric age continuum and utilize innovative modeling and simulation techniques to optimize the knowledge generated from these projects and help establish links between clinical and non-clinical findings. These projects and core activities will provide a rich training environment for future pediatric pharmacologist. While this RPDP program is focused to address developmental pharmacologic issues relating to antimicrobial therapy, understanding the determinants of Oat transporter maturation in both rat and humans has broad Implications for other classes of drugs undergoing renal excretion.