Developing Pediatric Clinical Pharmacologists for the Advancement of Therapeutics

 描述(由申请人提供)：尽管近年来成人药物疗法取得了巨大的进步，但将这些新疗法的益处扩大到婴儿和儿童仍然是一个重大的挑战。药代动力学、药效学、疾病表现和进展方面的重要发展变化都阻碍了成人治疗学直接转化为儿科治疗。儿科临床药理学学科提供发育生理学方面的必要培训，以利用现有知识并指导婴儿和儿童的合理治疗。然而，目前接受过临床药理学正规培训的药理学家和儿科专科专家人数很少，而且正在老龄化。这一由加州大学圣地亚哥分校(UCSD)儿科系领导的T32奖学金项目，题为培养促进治疗学的儿科临床药理学家(DPCPAT)，将提供儿科临床药理学方面的尖端研究培训和指导，使我们的受训人员成为儿科学术研究人员的领导者。加州大学圣迭戈分校的生物医学研究社区有着久负盛名的卓越声誉，目前在美国所有机构的NIH研究资金中排名前五。值得注意的是，在过去的5-10年里，加州大学圣迭戈分校儿科部门及其研究任务取得了令人印象深刻的学术扩张，同时圣地亚哥Rady儿童医院(RCHSD)与加州大学圣迭戈分校医学院和药房之间的协同关系也得到了巩固。我们将提供充分的证据，证明加州大学圣迭戈分校设立DPCPAT培训计划的时机从未像现在这样好，无论以什么标准衡量，我们的研究培训环境和师资都是真正的世界级的。DPCPAT计划的首要目标将是让儿科内科医生和科学家为持续、独立和高产出的研究的终身挑战做好准备。负责健康科学的院长兼副校长David Brenner博士、科学事务副校长Jack Dixon博士、儿科主任Gabriel Haddad博士和药学院院长James McKerrow博士为我们提议的DPCPAT提供了UCSD机构承诺函，证实了该项目对UCSD医学院学术使命的核心重要性。我们DPCAT的主要目标如下：(1)增加应用于儿童健康的临床药理学研究的儿科临床药剂师和临床医生科学家；(2)吸引优秀的年轻儿科临床医生到加州大学圣迭戈分校学习，并通过临床药理学方法扩大他们的翻译能力；(3)在世界级的知名研究员-教师导师的指导下促进DPCAT学员的职业发展；以及(4)培养儿童治疗学领域女性和少数族裔研究人员的早期职业生涯。有了我们令人印象深刻的导师团队和出色的培训记录，UCSD DPCPAT研究员将成为未来儿科临床药理学的领导者。

 DESCRIPTION (provided by applicant): While tremendous advances in pharmacotherapy for adults have been achieved in recent years, expanding the benefits of these new therapies to infants and children remains a significant challenge. Important developmental changes in pharmacokinetics, pharmacodynamics, disease presentation and progression all impede direct translation of adult therapeutics into pediatrics. The discipline of pediatric clinical pharmacolog provides necessary training in developmental physiology to leverage existing knowledge and guide rational therapeutics for infants and children. However, the current pool of pharmacologists and pediatric sub- specialists with formal training in clinical pharmacology is both small and aging. This T32 Fellowship Program led by the Department of Pediatrics at the University of California, San Diego (UCSD), entitled Developing Pediatric Clinical Pharmacologists for the Advancement of Therapeutics (DPCPAT), will provide cutting-edge research training and mentorship in pediatric clinical pharmacology, enabling our trainees to emerge as leaders among the ranks of pediatric academic investigators. The biomedical research community at UCSD has a long- established reputation of excellence, and now ranks in the top 5 in NIH research funding of all US institutions. Notably, the last 5-10 years have witnessed an impressive academic expansion within the UCSD Department of Pediatrics and its research mission, coupled with the solidification of the synergistic relationship among Rady Children's Hospital San Diego (RCHSD) and the UCSD Schools of Medicine and Pharmacy. We will provide ample evidence that the timing for creation of the DPCPAT training program at UCSD has never been better, and that our research training environment and faculty are truly world class by any measure. The overarching goal of the DPCPAT program will be to prepare Pediatric Physician-Scientists for the lifelong challenges of a sustained, independent and highly productive research. Dr. David Brenner, Dean and Vice Chancellor for Health Sciences, Dr. Jack Dixon, Associate Vice Chancellor for Scientific Affairs, Dr. Gabriel Haddad, Chair of the Department of Pediatrics and Dr. James McKerrow, Dean of the School of Pharmacy, have provided letters of UCSD institutional commitment to our proposed DPCPAT, confirming the central importance of this Program to the academic mission of the UCSD School of Medicine. The key objectives of our DPCAT are as follows: (1) To increase the number Pediatric clinical pharmacologists and Clinician-Scientists engaged in clinical pharmacology research as applied to child health; (2) to attract outstanding young pediatric clinicians to UCSD and to expand their translational capacity through clinical pharmacology methods; (3) to facilitate career development of DPCAT trainees under the guidance of world class, established investigator-faculty mentors; and (4) to cultivate the early careers of women and minority investigators in pediatric therapeutics. With our impressive group of mentors with outstanding training track records, UCSD DPCPAT Fellows will be poised to be tomorrow's leaders in pediatric clinical pharmacology.