Staying Strong and Healthy during Androgen Deprivation Therapy for Latino Men

雄激素剥夺疗法(ADT)正越来越多地用于前列腺癌的新辅助治疗和 放射治疗(RT)的辅助背景，用于手术或手术治疗后复发 放射治疗，或前列腺癌晚期。考虑到这一点变得非常重要 前列腺癌是美国男性最常见的非皮肤癌。特别的 令人担忧的是拉美裔男性，因为拉美裔是美国增长最快的少数族裔。拉丁裔 男性被诊断出患有晚期疾病，这使得他们更有可能接受ADT治疗。研究表明， 研究表明，服用ADT的男性出现血管舒缩症状、抑郁、疲劳、健康状况恶化的风险增加。 相关生活质量(HRQOL)、骨密度降低(BMD)、性功能障碍、代谢 综合征，脂肪质量增加，同时精瘦肌肉质量减少，血脂增加，以及 动脉顺应性降低，所有这些都使他们患心血管疾病(CVD)的风险更高， 骨质疏松症和II型糖尿病。拉丁裔更常患有肥胖症、血脂异常、心血管健康低下、 高血压和糖尿病。因此，我们建议测试我们的保持强壮和健康计划，以 促进拉丁裔男性在ADT期间的健康运动和营养。采用混合设计方法，我们的目标是：1. 比较干预前后的BMI、血脂、腰围/臀围以及75%以内和75%之间的血糖 开始ADT的拉丁裔男性被随机分配接受保持强壮和健康的干预 75名拉丁裔男性开始接受ADT，随机分配接受常规护理。2.比较前和后 使用SF-12情绪和身体幸福感分量表和疾病特异性分量表干预HRQOL 在组内和组间使用扩展前列腺癌综合指数(EPIC)的HRQOL。3.发展 并比较拉美裔男性的活动和营养选择的解释性模型 干预措施和那些接受常规护理的人。4.评估干预措施的可接受性和效益 参与者的视角。拉丁裔男性将从几个以拉丁裔为主的网站招募 洛杉矶的人口。男性将来到加州大学洛杉矶分校的翻译研究中心学习Baseline，6和12 12个月时进行测量和面谈。被分配到干预组的男性将收到首字母 在基线措施后立即进行营养和锻炼计划的评估和教育。 然后，他们将每周收到来自护士协调员/文化联络组的12个电话，以提供有针对性的 信息，建立个人量身定做的营养和活动目标，评估目标的成就和 提供支持。我们将对每组30名男性进行定性访谈，以评估干预措施 从他们的角度出发，并制定与粮食和粮食有关的决策过程的解释性框架 活动选择。分析将在组内和组内比较与扎根理论之间结合 技巧。

Androgen deprivation therapy (ADT) is increasingly being used to treat prostate cancer in the neoadjuvant and adjuvant contexts with radiation therapy (RT), for recurrence following primary treatment with surgery or radiation, or when the prostate cancer is at an advanced stage. This becomes highly significant considering that prostate cancer is the most commonly diagnosed noncutaneous cancer in American men. Of particular concern are Latino men, because Latinos are the fastest growing minority in the United States (US). Latino men are diagnosed with later stage disease making them more likely to be treated with ADT. Studies have shown that men on ADT are at increased risk for vasomotor symptoms, depression, fatigue, diminished health- related quality of life (HRQOL), decreased bone mineral density (BMD), sexual dysfunction, metabolic syndrome, increased fat mass, along with decreased lean muscle mass, increased serum lipids, and decreased arterial compliance all of which places them at higher risk for cardiovascular disease (CVD), osteoporosis, and type II diabetes. Latinos more often have obesity, dyslipidemia, low cardiovascular fitness, hypertension, and diabetes. Therefore, we propose to test our Staying Strong and Healthy program to promote healthy activity and nutrition during ADT for Latino men. Using a mixed methods design we aim to: 1. Compare pre- and post-intervention BMI, lipids, waist/hip circumference, and glucose within and between 75 Latino men starting ADT who are randomly assigned to receive the Staying Strong and Healthy intervention and 75 Latino men starting ADT randomly assigned to receive usual care. 2. Compare pre- and post- intervention HRQOL using the SF-12 subscales of emotional and physical well-being and disease-specific HRQOL using the Expanded Prostate Cancer Index Composite (EPIC) within and between groups. 3. Develop and compare explanatory models of Latino men's activity and nutrition choices between those receiving the intervention and those receiving usual care. 4. Evaluate acceptability and benefit of the intervention from perspective of participants. Latino men will be recruited form several sites serving predominantly Latino populations in Los Angeles. Men will come to UCLA Center for Translational Research for baseline, 6 and 12 months measures and interview at 12 months. Men assigned to the intervention group will receive initial assessment and education on nutrition and the exercised program immediately following baseline measures. They will then receive 12 weekly calls from a nurse coordinator/cultural liaison team to deliver focused information, establish individually tailored nutrition and activity goals, assess accomplishments of goals and provide support. We will conduct qualitative interview with 30 men from each group to assess the intervention from their perspective and to develop explanatory frameworks for decision process used relative to food and activity choices. Analysis will combine within and between group comparisons and grounded theory techniques.