Staying Strong and Healthy during Androgen Deprivation Therapy for Latino Men

拉丁裔男性在雄激素剥夺疗法期间保持强壮和健康

• 批准号: 8931060
• 负责人: SALLY L Maliski
• 金额: $ 61.98万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-23 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8931060
• 关键词: Accounting; Achievement; Address; Adjuvant; Adopted; Adoption; Adverse effects; American; Androgens; Attention; Awareness; Behavior; Blood Glucose; Body mass index; Bone Density; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Center for Translational Science Activities; Cessation of life; Cholesterol; Congestive Heart Failure; Cutaneous; Data; Diabetes Mellitus; Diagnosis; Disease; Dyslipidemias; Eating; Education; Emotional; Ethnic Origin; Event; Exercise; Fatigue; Fatty acid glycerol esters; Food; Glucose; Goals; Health; Height; High Density Lipoproteins; Hip region structure; Hispanics; Hot flushes; Hypertension; Individual; Intervention; Interview; Latino; Lipids; Los Angeles; Low-Density Lipoproteins; Malignant Neoplasms; Malignant neoplasm of prostate; Measures; Mental Depression; Metabolic; Metabolic syndrome; Methods; Minority; Modeling; Monitor; Morbidity - disease rate; Myocardial Infarction; Neoadjuvant Therapy; Non-Insulin-Dependent Diabetes Mellitus; Nurses; Obesity; Operative Surgical Procedures; Osteoporosis; Outcome; Outcome Measure; Participant; Patients; Perception; Personal Communication; Personal Satisfaction; Physiological; Prevention program; Process; Prostate Cancer Outcomes Study; Prostate Cancer therapy; Quality of life; Radiation; Radiation therapy; Randomized; Recruitment Activity; Recurrence; Relative (related person); Risk; SF-12; Serum; Sexual Dysfunction; Site; Stage at Diagnosis; Staging; Subgroup; Techniques; Telephone; Testing; Time; Triglycerides; United States; Vasomotor; Visceral; Waist-Hip Ratio; Weight; Wife; cancer diagnosis; cardiovascular disorder risk; comparison group; depressive symptoms; deprivation; design; diabetes risk; fitness; good diet; group intervention; health related quality of life; high risk; improved; indexing; interest; men; muscle form; nutrition; post intervention; programs; theories; treatment as usual

DESCRIPTION (provided by applicant): Androgen deprivation therapy (ADT) is increasingly being used to treat prostate cancer in the neoadjuvant and adjuvant contexts with radiation therapy (RT), for recurrence following primary treatment with surgery or radiation, or when the prostate cancer is at an advanced stage. This becomes highly significant considering that prostate cancer is the most commonly diagnosed no cutaneous cancer in American men. Of particular concern are Latino men, because Latinos are the fastest growing minority in the United States (US). Latino men are diagnosed with later stage disease making them more likely to be treated with ADT. Studies have shown that men on ADT are at increased risk for vasomotor symptoms, depression, fatigue, diminished health- related quality of life (HRQOL), decreased bone mineral density (BMD), sexual dysfunction, metabolic syndrome, increased fat mass, along with decreased lean muscle mass, increased serum lipids, and decreased arterial compliance all of which places them at higher risk for cardiovascular disease (CVD), osteoporosis, and type II diabetes. Latinos more often have obesity, dyslipidemia, low cardiovascular fitness, hypertension, and diabetes. Therefore, we propose to test our Staying Strong and Healthy program to promote healthy activity and nutrition during ADT for Latino men. Using a mixed methods design we aim to: 1. Compare pre- and post-intervention BMI, lipids, waist/hip circumference, and glucose within and between 75 Latino men starting ADT who are randomly assigned to receive the Staying Strong and Healthy intervention and 75 Latino men starting ADT randomly assigned to receive usual care. 2. Compare pre- and post- intervention HRQOL using the SF-12 subscales of emotional and physical well-being and disease-specific HRQOL using the Expanded Prostate Cancer Index Composite (EPIC) within and between groups. 3. Develop and compare explanatory models of Latino men's activity and nutrition choices between those receiving the intervention and those receiving usual care. 4. Evaluate acceptability and benefit of the intervention from perspective of participants. Latino men will be recruited form several sites serving predominantly Latino populations in Los Angeles. Men will come to UCLA Center for Translational Research for baseline, 6 and 12 months measures and interview at 12 months. Men assigned to the intervention group will receive initial assessment and education on nutrition and the exercised program immediately following baseline measures. They will then receive 12 weekly calls from a nurse coordinator/cultural liaison team to deliver focused information, establish individually tailored nutrition and activity goals, assess accomplishments of goals and provide support. We will conduct qualitative interview with 30 men from each group to assess the intervention from their perspective and to develop explanatory frameworks for decision process used relative to food and activity choices. Analysis will combine within and between group comparisons and grounded theory techniques.

描述（由申请人提供）：雄激素剥夺疗法（ADT）越来越多地用于治疗前列腺癌的新辅助治疗和放射疗法（RT）辅助治疗，用于手术或放射初次治疗后的复发，或前列腺癌处于晚期。考虑到前列腺癌是美国男性中最常见的非皮肤癌，这变得非常重要。特别值得关注的是拉丁裔男性，因为拉丁裔是美国增长最快的少数民族。拉丁裔男性被诊断为晚期疾病，使他们更有可能接受ADT治疗。研究表明，接受ADT治疗的男性发生血管扩张症状、抑郁、疲劳、健康相关生活质量（HRQOL）降低、骨矿物质密度（BMD）降低、性功能障碍、代谢综合征、脂肪量增加、沿着瘦肌肉量减少、血脂增加和动脉顺应性降低的风险增加，所有这些都使他们发生心血管疾病（CVD）、骨质疏松症、和II型糖尿病拉美裔人更容易患肥胖症、血脂异常、心血管功能低下、高血压和糖尿病。因此，我们建议测试我们保持强壮和健康的计划，以促进拉丁裔男性ADT期间的健康活动和营养。使用混合方法设计，我们的目标是：1。比较干预前和干预后的BMI，血脂，腰围/臀围和葡萄糖内和75名拉丁裔男性开始ADT谁被随机分配接受保持强壮和健康的干预和75名拉丁裔男性开始ADT随机分配接受常规护理。2.使用SF-12情绪和身体健康子量表比较干预前后的HRQOL，使用扩展前列腺癌综合指数（EPIC）比较组内和组间疾病特异性HRQOL。3.开发和比较解释模型的拉丁美洲男子的活动和营养选择之间的那些接受干预和那些接受常规护理。4.从参与者的角度评价干预的可接受性和受益。拉丁裔男子将从洛杉矶几个主要为拉丁裔人口服务的地点招募。男性将前往加州大学洛杉矶分校转化研究中心进行基线、6个月和12个月的测量，并在12个月时进行访谈。分配到干预组的男性将在基线测量后立即接受营养和锻炼计划的初步评估和教育。然后，他们将每周接到护士协调员/文化联络小组的12个电话，提供重点信息，制定个性化的营养和活动目标，评估目标的实现情况并提供支持。我们将对每组30名男性进行定性访谈，从他们的角度评估干预措施，并为食物和活动选择相关的决策过程制定解释框架。分析将结合联合收割机内部和之间的组比较和扎根理论技术。