Building research capacity in aging HIV-infected persons

建设老年艾滋病毒感染者的研究能力

• 批准号: 8735839
• 负责人: RONALD J. ELLIS
• 金额: $ 7.03万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8735839
• 关键词: AIDS/HIV problem; Address; Affect; Age; Age-Years; Aged, 80 and over; Aging; Anti-Retroviral Agents; Brain; California; Caring; Case Report Form; Centers for Disease Control and Prevention (U.S.); Certification; Cities; Clinical Research; Communities; Community Services; Comorbidity; County; Databases; Disease; Elderly; Eligibility Determination; Evaluation; Feasibility Studies; Feedback; Focus Groups; Funding; Future; Goals; HIV; HIV Infections; Health; Human Resources; Impairment; Individual; Information Dissemination; Institutional Review Boards; Interdisciplinary Study; Intervention; Intervention Studies; Interview; Letters; Life; Logistics; Los Angeles; Medical; Methods; National Institute of Mental Health; Nervous System Physiology; Neurocognitive; Neurologic; Outcome Measure; Persons; Population; Probability; Productivity; Provider; Public Health; Publishing; Quality of life; Recruitment Activity; Reporting; Research; Research Infrastructure; Research Personnel; Resources; Risk; Secure; Site; Structure; Teleconferences; Training; Travel; Universities; Woman; antiretroviral therapy; base; cohort; community consultation; disability; human subject protection; interest; meetings; men; multidisciplinary; neurobehavioral; neuropsychological; peer; premature; public health relevance; quality assurance; response; sensory neuropathy; success; volunteer

DESCRIPTION (provided by applicant): A critical barrier to progress in multidisciplinary clinical research on HIV and aging is the paucity in clinical studies to date of truly older HIV-infected (HIV+) individuals - those in whom the synergistic effects of HIV and age on brain structure and function are most likely to be observed. Although HIV+ people in the U.S. are now living into old age with long-term combination antiretroviral treatment (CART) and the U.S. CDC estimates that by 2015 more than 10% of all HIV+ individuals will exceed 65 years of age (i.e., older HIV+), very few such individuals have actually been included in published reports. We propose to capitalize on a unique geographic concentration of HIV+ individuals over age 65 in a cluster of desert communities nearby to San Diego, where their proportion has already exceeded 10%. We will establish a productive, collaborative partnership between the aging HIV+ community in Riverside County and the multidisciplinary UCSD HIV Neurobehavioral Research Center (HNRC) to investigate neurological functioning among older HIV+ individuals. We will strengthen and evolve an emerging alliance between desert community activists and HNRC researchers. We will leverage the well- established, NIMH-funded HNRC infrastructure to establish this new cohort with modest support. We will demonstrate feasibility by training local personnel in high-quality clinical research evaluations and by establishing an initial cohort of 20 well-characterized older HIV+ persons. These preliminary efforts will support the establishment of an expanded clinical research infrastructure for planned future studies on interventions to maximize neurological health, productivity and quality of life in the "oldest old" HIV+ persons.

描述（由申请人提供）：多学科临床研究和衰老的临床临床研究的关键障碍是迄今为止临床研究的匮乏，迄今为止，真正感染了HIV的人（HIV+）个体 - 艾滋病毒和年龄对大脑结构和功能的协同作用的人最有可能观察到那些对大脑结构和功能的协同作用。尽管美国的艾滋病毒+人现在以长期组合抗逆转录病毒治疗（CART）生活在老年中，并且美国疾病预防控制中心估计，到2015年，所有HIV+个体中的10％以上将超过65岁（即较老的HIV+），但实际上很少有这样的人包括在公开的报告中。我们建议在圣地亚哥附近的一群沙漠社区中利用65岁以上的艾滋病毒+个体的独特地理集中度，那里的比例已经超过10％。我们将在河滨县老龄化的HIV+社区与多学科的UCSD HIV HIV神经行为研究中心（HNRC）之间建立富有成效的合作伙伴关系，以研究老年HIV+个体的神经功能。我们将加强和发展沙漠社区活动家和HNRC研究人员之间的新兴联盟。我们将利用良好的NIMH资助的HNRC基础架构来建立这个新的队列，并提供适度的支持。我们将通过培训当地人员进行高质量的临床研究评估，并建立20个同类，以证明可行性 特征良好的老年艾滋病毒+人。这些初步努力将支持建立扩展的临床研究基础设施，以实现对干预措施的未来研究，以最大程度地提高“最古老的老式”艾滋病毒+人的神经健康，生产力和生活质量。