3T MRI Scanner for multidisciplinary imaging and image-guided therapy

用于多学科成像和图像引导治疗的 3T MRI 扫描仪

• 批准号: 8733938
• 负责人: Gregory S. Karczmar
• 金额: $ 200万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-15 至 2016-12-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8733938
• 关键词: Ablation; Anatomy; Behavior Disorders; Body Image; Breast Cancer Treatment; Cancer Center; Chicago; Clinical; Clinical Trials; Cognitive; Development; Drug abuse; Empathy; Engineering; Faculty; Focused Ultrasound Therapy; Functional Imaging; Funding; Grant; Healthcare; Human; Image; Image Analysis; Industry; Institutes; Intervention; Investments; Laboratories; Laboratory Animals; Lasers; Lead; Magnetic Resonance Imaging; Malignant Neoplasms; Malignant neoplasm of brain; Malignant neoplasm of prostate; Memory; Molecular; Neurosciences; Performance; Pharmaceutical Preparations; Postdoctoral Fellow; Procedures; Radiology Specialty; Research; Research Project Grants; Research Support; Resources; Rodent; Site; Sleep Disorders; System; Universities; Work; addiction; anticancer research; experience; graduate student; image guided therapy; image reconstruction; imaging modality; improved; instrumentation; malignant breast neoplasm; multidisciplinary; new technology; oncology; programs

ABSTRACT/SUMMARY The University of Chicago MRI Research Center proposes to upgrade our existing 3 Tesla MRI scanner to accommodate a wide range of research projects from oncology and neuroscience, as well as development of improved anatomic and functional imaging methods, image reconstruction, image analysis, and MRI-guided interventional procedures. Our current scanner was funded by high end instrumentation grant in 2008 and over the past 5 years, the scanner has supported over 30 very productive functional neuro-imaging projects. As part of this application we are proposing a larger multidisciplinary user group, which would increase efficiency and lead to important synergies between projects. This upgrade is urgently needed to improve the performance of the scanner for neuro-imaging, and to equip the scanner for body imaging and MRI-guided interventions. The MRI system will support studies of humans as well as both larger laboratory animals and rodents. The scanner will continue to support highly productive cognitive research on empathy, behavioral and sleep disorders, memory, addiction, and drug abuse. We propose to add new cancer research including quantitative imaging of breast and prostate cancer, clinical drug trials, and MRI-guided high intensity focused ultrasound and laser ablation for treatment of breast, prostate, and brain cancers. The proposed scanner will support research funded by 12 RO1's, 2 R21's, an R25 and multiple clinical trials and industry sponsored studies. The scanner will be part of an MRI research Center with a highly experienced faculty and staff. Dr. Karczmar has over 30 years of experience in development of new functional and anatomic MR imaging methods, and applications of MRI to cancer. Dr. Sammet has extensive experience in high field imaging, and neuro-imaging. Dr. Oto has a strong research program in imaging and image-guided therapy of prostate cancer, and use of MRI in clinical trials. Dr. Decety is an internationally recognized expert in cognitive imaging. Drs. Guo and Medved are experienced MRI physicists and provide strong technical support. Two post-doctoral fellows, 4 graduate students, and 2 research technicians work in the MRI Research Center. UC has been a luminary site of Philips Healthcare for many years, and the strong relationship with Philips strengthens research and provides access to new technology. The MRI Research Center is a critical resource for the Radiology Department, the Cancer Center, the new Molecular Engineering and Neuroscience Institutes, and other UC departments. The scanner upgrade will be accompanied by significant investments in new faculty, staff, and laboratories by the Radiology Department, the BSD, and the Cancer Center. New faculty recruitments will enhance neuro-imaging and MRI-guided therapy. As a result the new scanner will be a central component of a strong multidisciplinary MRI research program.

摘要/总结 芝加哥大学MRI研究中心建议将我们现有的3特斯拉MRI扫描仪升级为 容纳广泛的研究项目，从肿瘤学和神经科学，以及发展 改进的解剖和功能成像方法、图像重建、图像分析和MRI引导 介入手术。我们目前的扫描仪是由高端仪器赠款在2008年资助， 在过去5年中，该扫描仪支持了30多个非常富有成效的功能性神经成像项目。 作为该应用程序的一部分，我们提出了一个更大的多学科用户群，这将增加 效率并带来项目之间的重要协同作用。这一升级迫切需要改善 神经成像扫描仪的性能，并配备身体成像和MRI引导的扫描仪 干预措施。MRI系统将支持对人类以及大型实验室动物的研究， 啮齿动物该扫描仪将继续支持关于同理心、行为和 睡眠障碍、记忆、成瘾和药物滥用。我们建议增加新的癌症研究，包括 乳腺癌和前列腺癌的定量成像、临床药物试验和MRI引导的高强度聚焦 超声和激光消融用于治疗乳腺癌、前列腺癌和脑癌。拟议的扫描仪将 支持由12个RO 1、2个R21、1个R25资助的研究以及多项临床试验和行业赞助的研究 问题研究该扫描仪将成为MRI研究中心的一部分，拥有经验丰富的教职员工。博士 Karczmar在开发新的功能和解剖MR成像方面拥有30多年的经验 方法和MRI在癌症中的应用。Sammet博士在高场成像方面拥有丰富的经验， 神经成像Oto博士在前列腺成像和图像引导治疗方面拥有强大的研究计划 癌症和MRI在临床试验中的应用。Decety博士是国际公认的认知成像专家。 Drs. Guo和Medved是经验丰富的MRI物理学家，并提供强大的技术支持。两名博士后 研究员、4名研究生和2名研究技术人员在MRI研究中心工作。UC是一个 飞利浦医疗多年来一直是飞利浦医疗的重要网站，与飞利浦的牢固关系得到加强 研究并提供新技术。MRI研究中心是一个关键的资源， 放射科，癌症中心，新的分子工程和神经科学研究所， UC其他部门扫描仪的升级将伴随着对新教师的大量投资， 放射科、BSD和癌症中心的工作人员和实验室。新教师 招募将加强神经成像和MRI引导的治疗。因此，新的扫描仪将是一个中央 一个强大的多学科MRI研究计划的组成部分。

项目成果

External motivation to avoid prejudice alters neural responses to targets varying in race and status.

避免偏见的外部动机会改变对不同种族和地位目标的神经反应。

• DOI: 10.1093/scan/nsx128
• 发表时间: 2018
• 期刊: Social cognitive and affective neuroscience
• 影响因子: 4.2
• 作者: Mattan,BradleyD;Kubota,JenniferT;Dang,TzipporahP;Cloutier,Jasmin
• 通讯作者: Cloutier,Jasmin

Effect of Echo Times on Prostate Cancer Detection on T2-Weighted Images.

回波时间对 T2 加权图像前列腺癌检测的影响。

• DOI: 10.1016/j.acra.2019.12.014
• 发表时间: 2020
• 期刊: Academic radiology
• 影响因子: 4.8
• 作者: Chatterjee,Aritrick;Nolan,Paul;Sun,Chongpeng;Mathew,Melvy;Dwivedi,Durgesh;Yousuf,Ambereen;Antic,Tatjana;Karczmar,GregoryS;Oto,Aytekin
• 通讯作者: Oto,Aytekin

Prostate Cancers Invisible on Multiparametric MRI: Pathologic Features in Correlation with Whole-Mount Prostatectomy.

• DOI: 10.3390/cancers15245825
• 发表时间: 2023-12-13
• 期刊: CANCERS
• 影响因子: 5.2
• 作者: Chatterjee, Aritrick;Gallan, Alexander;Fan, Xiaobing;Medved, Milica;Akurati, Pranadeep;Bourne, Roger M.;Antic, Tatjana;Karczmar, Gregory S.;Oto, Aytekin
• 通讯作者: Oto, Aytekin

Motivation Modulates Brain Networks in Response to Faces Varying in Race and Status: A Multivariate Approach.

动机调节大脑网络以响应种族和地位不同的面孔：一种多元方法。

• DOI: 10.1523/eneuro.0039-18.2018
• 发表时间: 2018
• 期刊: eNeuro
• 影响因子: 3.4
• 作者: Mattan,BradleyD;Kubota,JenniferT;Li,Tianyi;Dang,TzipporahP;Cloutier,Jasmin
• 通讯作者: Cloutier,Jasmin