Prostate Cancers Invisible on Multiparametric MRI: Pathologic Features in Correlation with Whole-Mount Prostatectomy.
Prostate Cancers Invisible on Multiparametric MRI: Pathologic Features in Correlation with Whole-Mount Prostatectomy.
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多参数MRI上不可见的前列腺癌：与全前列腺切除术相关的病理特征。
DOI：
10.3390/cancers15245825
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发表时间：
2023-12-13
期刊：
影响因子：
5.2
通讯作者：
Oto, Aytekin
中科院分区：
文献类型：
--
作者：
Chatterjee, Aritrick;Gallan, Alexander;Fan, Xiaobing;Medved, Milica;Akurati, Pranadeep;Bourne, Roger M.;Antic, Tatjana;Karczmar, Gregory S.;Oto, Aytekin
我们研究了为什么一些前列腺癌（PCas）没有确定多参数MRI（mpMRI）通过使用地面真值参考从整体安装的前列腺切除术标本。共61例PCa患者接受了3 T mpMRI，随后进行了前列腺切除术。与组织学相关后，前瞻性或回顾性确定的MRI可见病变被视为“确定的癌症”（IC）。在mpMRI上无法识别的病变被认为是“未识别的癌症”（UC）。病理学家标记Gleason评分、阶段、大小和癌腺体的密度，并进行定量组织学以计算组织组成。与IC相比，UC明显更小，具有更低的Gleason评分和临床分期病变，具有更低的癌腺体密度。与大小和Gleason评分无关，组织组成差异，特别是UC中较高的管腔和较低的上皮（与较高的T2和ADC相关），可以解释为什么一些前列腺癌无法在mpMRI上识别。我们研究了为什么一些前列腺癌（PCas）没有确定多参数MRI（mpMRI）通过使用地面真值参考从整体安装的前列腺切除术标本。共有61例活检证实的PCa患者接受了3 T mpMRI，随后进行了前列腺切除术。与组织学相关后，前瞻性或回顾性确定的MRI可见病变被视为“确定的癌症”（IC）。在mpMRI上无法识别的病变被认为是“未识别的癌症”（UC）。病理学家标记Gleason评分、阶段、大小和癌腺体的密度，并进行定量组织学以计算组织组成。在115例癌症中，19例在MRI上未被识别。UC与IC相比明显较小，Gleason评分和临床分期病变较低。UC的ADC（1.34 ± 0.38 vs. 1.02 ± 0.30 μm2/ms）和T2（117.0 ± 31.1 vs. 97.1 ± 25.1 ms）显著（p < 0.05）高于IC。UC中癌腺的密度显着较低（p = 0.04）。与UC（15 ± 8%）相比，IC（20 ± 12%）中Gleason 3 + 4病变中Gleason 4组分的百分比名义上（p = 0.15）更高。与IC相比，UC具有显著更低的上皮（32.9 ± 21.5 vs. 47.6 ± 13.1%，p = 0.034）和更高的管腔体积（20.4 ± 10.0 vs. 13.3 ± 4.1%，p = 0.021）。与大小和Gleason评分无关，组织组成差异，特别是UC中较高的管腔和较低的上皮，可以解释为什么一些前列腺癌无法在mpMRI上识别。
We investigated why some prostate cancers (PCas) are not identified on multiparametric MRI (mpMRI) by using ground truth reference from whole-mount prostatectomy specimens. A total of 61 patients with PCa underwent 3T mpMRI followed by prostatectomy. Lesions visible on MRI prospectively or retrospectively identified after correlating with histology were considered “identified cancers” (ICs). Lesions that could not be identified on mpMRI were considered “unidentified cancers” (UCs). Pathologists marked the Gleason score, stage, size, and density of cancer glands and performed quantitative histology to calculate the tissue composition. The UCs were significantly smaller, had lower Gleason scores and clinical stage lesions, with a lower density of cancer glands, compared with the ICs. Independent from size and Gleason score, tissue composition differences, specifically, the higher lumen and lower epithelium in UCs (associated with higher T2 and ADC), can explain why some of the prostate cancers cannot be identified on mpMRI. We investigated why some prostate cancers (PCas) are not identified on multiparametric MRI (mpMRI) by using ground truth reference from whole-mount prostatectomy specimens. A total of 61 patients with biopsy-confirmed PCa underwent 3T mpMRI followed by prostatectomy. Lesions visible on MRI prospectively or retrospectively identified after correlating with histology were considered “identified cancers” (ICs). Lesions that could not be identified on mpMRI were considered “unidentified cancers” (UCs). Pathologists marked the Gleason score, stage, size, and density of the cancer glands and performed quantitative histology to calculate the tissue composition. Out of 115 cancers, 19 were unidentified on MRI. The UCs were significantly smaller and had lower Gleason scores and clinical stage lesions compared with the ICs. The UCs had significantly (p < 0.05) higher ADC (1.34 ± 0.38 vs. 1.02 ± 0.30 μm2/ms) and T2 (117.0 ± 31.1 vs. 97.1 ± 25.1 ms) compared with the ICs. The density of the cancer glands was significantly (p = 0.04) lower in the UCs. The percentage of the Gleason 4 component in Gleason 3 + 4 lesions was nominally (p = 0.15) higher in the ICs (20 ± 12%) compared with the UCs (15 ± 8%). The UCs had a significantly lower epithelium (32.9 ± 21.5 vs. 47.6 ± 13.1%, p = 0.034) and higher lumen volume (20.4 ± 10.0 vs. 13.3 ± 4.1%, p = 0.021) compared with the ICs. Independent from size and Gleason score, the tissue composition differences, specifically, the higher lumen and lower epithelium in UCs, can explain why some of the prostate cancers cannot be identified on mpMRI.
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DOI：
10.1007/s00261-021-03371-7
发表时间：
2022-03
期刊：
Abdominal radiology (New York)
影响因子：
--
作者：
Chatterjee A;Antic T;Gallan AJ;Paner GP;Lin LI;Karczmar GS;Oto A
通讯作者：
Oto A
影响因子：
4.4
作者：
Lin, Yu-Chun;Lin, Gigin;Wang, Chun-Chieh
通讯作者：
Wang, Chun-Chieh
影响因子：
2.4
作者：
Chatterjee, Aritrick;Gallan, Alexander J.;Oto, Aytekin
通讯作者：
Oto, Aytekin
影响因子：
4.4
作者：
Isebaert, Sofie;Van den Bergh, Laura;Oyen, Raymond
通讯作者：
Oyen, Raymond
影响因子：
2.4
作者：
Bajgiran, Amirhossein Mohammadian;Mirak, Sohrab Afshari;Raman, Steven S.
通讯作者：
Raman, Steven S.