Invasive breast cancer with and without DCIS: Race, risk factors and outcomes
伴或不伴 DCIS 的浸润性乳腺癌:种族、危险因素和结果
基本信息
- 批准号:8634076
- 负责人:
- 金额:$ 9.05万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-04-01 至 2015-03-31
- 项目状态:已结题
- 来源:
- 关键词:AffectAfricanAfrican AmericanAggressive courseAmericanAreaBiologicalBreastBreast Cancer Risk FactorCase-Control StudiesCharacteristicsChemopreventionClinicalCox Proportional Hazards ModelsDataData SetDatabasesDecision MakingDevelopmentDiagnosisDiseaseDisease OutcomeEpidemiologistEstrogen receptor negativeEstrogen receptor positiveEtiologyEuropeanEvaluationEventFLT1 geneFibroblast Growth Factor 2FreezingGenesGeneticGoalsHealthHistologyHormonalImmunohistochemistryIn SituIndolentInsulin-Like Growth Factor IInterdisciplinary StudyInterferonsInterleukin-6KnowledgeLesionLiteratureMMP11 geneMalignant - descriptorMalignant NeoplasmsMammary NeoplasmsMammographyMeasuresNoninfiltrating Intraductal CarcinomaOperative Surgical ProceduresOutcomePTGS2 genePathway interactionsPatientsPhenotypePopulation StudyPositive Lymph NodePreventionProcessPrognostic FactorProteinsRaceRecurrenceResearchRisk FactorsRoleRoswell Park Cancer InstituteSamplingSocioeconomic StatusSubgroupSuggestionTNF geneTherapeuticTimeTissue Inhibitor of Metalloproteinase-3Tissue SampleTreatment outcomeTumor TissueVisitWomancarcinogenesisclinically significantcohortdesigndisease characteristicexperiencefollow-upinfiltrating duct carcinomainterdisciplinary approachmalignant breast neoplasmmolecular phenotypemortalitynoveloutcome forecastprognosticprogramsprotein expressionpublic health relevancereproductiveresearch studyscreeningtumor
项目摘要
DESCRIPTION (provided by applicant): There has been little research conducted to determine if pure invasive ductal carcinoma (IDC) with no concomitant ductal carcinoma in situ (DCIS) differs from mixed IDC with DCIS in etiology, prognosis, or microenvironment, although there are some suggestions in the literature that pure IDC is likely to have a more aggressive course. The goal of this proposed research is to conduct a thorough examination of this phenomenon. We will examine risk factors for pure IDC vs mixed IDC with DCIS using data from a case- control study (n= 3715) designed to examine predictors of early/aggressive breast cancer in African-American and European-American women. We will first determine if pure IDC is more common in AA than in EA women, and characterize associated tumor characteristics for both phenotypes. Risk factors, particularly reproductive and hormonal factors, will be examined, with consideration of factors related to socioeconomic status and screening. Then, in a second cohort of 1588 women treated at Roswell Park Cancer Institute from 1995 to 2005 and followed up for treatment outcomes, we will examine associations between tumor and disease characteristics and pure IDC as well as mixed IDC with DCIS. Cox proportional hazard modeling will be used to determine disease and treatment outcomes among women in both of these groups, with consideration of other disease characteristics and treatments received. We hypothesize that women with pure IDC will be more likely to have aggressive tumor characteristics, and have more recurrences and shorter survival times than women with mixed IDC with DCIS. Finally, in an exploratory analysis using banked frozen tissue samples, we will microdissect stromal tissue from tumors from 15 women with pure IDC and 15 women with mixed IDC with DCIS and use real-time quantitative PCR to examine levels of expression of IL-6, TNF-¿, IFN-?, Cox-2, IGF-1, bFGF, TGF¿-1, fmsFLT1, MMP11 and TIMP-3, known for their role in tumor development, within each group. This proposed multidisciplinary research study, led by an epidemiologist and a breast biologist, will be the first to investigate the distribution f pure IDC and mixed IDC with DCIS by ancestry and to examine risk factors for each pathway, a previously unexplored area. In a large data set, we will evaluate the prognostic significance of these clinical subgroups, and in an exploratory pilot analysis, we will examine mechanisms by which specific pathways in the stromal microenvironment contribute to the pathobiological differences in IDC with and without concomitant DCIS.
描述(由申请人提供):尽管文献中有一些建议认为单纯浸润性导管癌(IDC)可能具有更具侵袭性的病程,但很少有研究确定不伴导管原位癌(DCIS)的单纯浸润性导管癌(IDC)与伴DCIS的混合型IDC在病因、预后或微环境方面是否不同。这项研究的目的是对这一现象进行彻底的研究。我们将使用来自病例对照研究(n= 3715)的数据来检查纯IDC与混合IDC与DCIS的风险因素,该研究旨在检查非洲裔美国人和欧洲裔美国人女性中早期/侵袭性乳腺癌的预测因子。我们将首先确定单纯IDC在AA中是否比EA女性更常见,并描述两种表型的相关肿瘤特征。将检查风险因素,特别是生殖和激素因素,并考虑与社会经济地位和筛查相关的因素。然后,在1995年至2005年在Roswell Park癌症研究所接受治疗的1588名妇女的第二个队列中,我们将研究肿瘤和疾病特征与单纯IDC以及混合IDC与DCIS之间的关系。将使用考克斯比例风险模型来确定这两组女性的疾病和治疗结局,并考虑其他疾病特征和接受的治疗。我们假设,与单纯IDC的女性将更有可能有侵略性的肿瘤特征,并有更多的复发和较短的生存时间比混合IDC与DCIS的女性。最后,在使用冷冻组织样本库进行的探索性分析中,我们将显微解剖15名单纯IDC患者和15名IDC与DCIS混合患者的肿瘤间质组织,并使用实时定量PCR检测IL-6、TNF-α、IFN-β、考克斯-2、IGF-1、bFGF、TGF β-1、fmsFLT 1、MMP 11和TIMP-3,已知它们在肿瘤发展中的作用。这项由流行病学家和乳腺生物学家领导的多学科研究将首次调查纯IDC和混合IDC与DCIS的分布,并检查每种途径的风险因素,这是一个以前未探索的领域。在一个大的数据集中,我们将评估这些临床亚组的预后意义,并在探索性初步分析中,我们将研究基质微环境中的特定途径对伴或不伴DCIS的IDC的病理生物学差异的作用机制。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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Christine B. Ambrosone其他文献
Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification
对超过 40 万名女性的分析为 BRCA1 和 BRCA2 变异分类提供了病例对照证据
- DOI:
10.1038/s41467-025-59979-6 - 发表时间:
2025-05-25 - 期刊:
- 影响因子:15.700
- 作者:
Maria Zanti;Denise G. O’Mahony;Michael T. Parsons;Leila Dorling;Joe Dennis;Nicholas J. Boddicker;Wenan Chen;Chunling Hu;Marc Naven;Kristia Yiangou;Thomas U. Ahearn;Christine B. Ambrosone;Irene L. Andrulis;Antonis C. Antoniou;Paul L. Auer;Caroline Baynes;Clara Bodelon;Natalia V. Bogdanova;Stig E. Bojesen;Manjeet K. Bolla;Kristen D. Brantley;Nicola J. Camp;Archie Campbell;Jose E. Castelao;Melissa H. Cessna;Jenny Chang-Claude;Fei Chen;Georgia Chenevix-Trench;Don M. Conroy;Kamila Czene;Arcangela De Nicolo;Susan M. Domchek;Thilo Dörk;Alison M. Dunning;A. Heather Eliassen;D. Gareth Evans;Peter A. Fasching;Jonine D. Figueroa;Henrik Flyger;Manuela Gago-Dominguez;Montserrat García-Closas;Gord Glendon;Anna González-Neira;Felix Grassmann;Andreas Hadjisavvas;Christopher A. Haiman;Ute Hamann;Steven N. Hart;Mikael B. A. Hartman;Weang-Kee Ho;James M. Hodge;Reiner Hoppe;Sacha J. Howell;Anna Jakubowska;Elza K. Khusnutdinova;Yon-Dschun Ko;Peter Kraft;Vessela N. Kristensen;James V. Lacey;Jingmei Li;Geok Hoon Lim;Sara Lindström;Artitaya Lophatananon;Craig Luccarini;Arto Mannermaa;Maria Elena Martinez;Dimitrios Mavroudis;Roger L. Milne;Kenneth Muir;Katherine L. Nathanson;Rocio Nuñez-Torres;Nadia Obi;Janet E. Olson;Julie R. Palmer;Mihalis I. Panayiotidis;Alpa V. Patel;Paul D. P. Pharoah;Eric C. Polley;Muhammad U. Rashid;Kathryn J. Ruddy;Emmanouil Saloustros;Elinor J. Sawyer;Marjanka K. Schmidt;Melissa C. Southey;Veronique Kiak-Mien Tan;Soo Hwang Teo;Lauren R. Teras;Diana Torres;Amy Trentham-Dietz;Thérèse Truong;Celine M. Vachon;Qin Wang;Jeffrey N. Weitzel;Siddhartha Yadav;Song Yao;Gary R. Zirpoli;Melissa S. Cline;Peter Devilee;Sean V. Tavtigian;David E. Goldgar;Fergus J. Couch;Douglas F. Easton;Amanda B. Spurdle;Kyriaki Michailidou - 通讯作者:
Kyriaki Michailidou
Association between TP53 and p21 genetic polymorphisms and acute side effects of radiotherapy in breast cancer patients
- DOI:
10.1007/s10549-005-9119-2 - 发表时间:
2005-12-06 - 期刊:
- 影响因子:3.000
- 作者:
Xiang-Lin Tan;Odilia Popanda;Christine B. Ambrosone;Silke Kropp;Irmgard Helmbold;Dietrich von Fournier;Wulf Haase;Marie Luise Sautter-Bihl;Frederik Wenz;Peter Schmezer;Jenny Chang-Claude - 通讯作者:
Jenny Chang-Claude
Erratum to: DNA hypermethylation and clinicopathological features in breast cancer: the Western New York Exposures and Breast Cancer (WEB) Study
- DOI:
10.1007/s10549-013-2660-5 - 发表时间:
2013-08-01 - 期刊:
- 影响因子:3.000
- 作者:
Meng Hua Tao;Peter G. Shields;Jing Nie;Amy Millen;Christine B. Ambrosone;Stephen B. Edge;Shiva S. Krishnan;Catalin Marian;Bin Xie;Janet Winston;Dominica Vito;Maurizio Trevisan;Jo L. Freudenheim - 通讯作者:
Jo L. Freudenheim
Refining breast cancer genetic risk and biology through multi-ancestry fine-mapping analyses of 192 risk regions
通过对 192 个风险区域的多祖先精细定位分析来完善乳腺癌的遗传风险和生物学
- DOI:
10.1038/s41588-024-02031-y - 发表时间:
2025-01-03 - 期刊:
- 影响因子:29.000
- 作者:
Guochong Jia;Zhishan Chen;Jie Ping;Qiuyin Cai;Ran Tao;Chao Li;Joshua A. Bauer;Yuhan Xie;Stefan Ambs;Mollie E. Barnard;Yu Chen;Ji-Yeob Choi;Yu-Tang Gao;Montserrat Garcia-Closas;Jian Gu;Jennifer J. Hu;Motoki Iwasaki;Esther M. John;Sun-Seog Kweon;Christopher I. Li;Koichi Matsuda;Keitaro Matsuo;Katherine L. Nathanson;Barbara Nemesure;Olufunmilayo I. Olopade;Tuya Pal;Sue K. Park;Boyoung Park;Michael F. Press;Maureen Sanderson;Dale P. Sandler;Chen-Yang Shen;Melissa A. Troester;Song Yao;Ying Zheng;Thomas Ahearn;Abenaa M. Brewster;Adeyinka Falusi;Anselm J. M. Hennis;Hidemi Ito;Michiaki Kubo;Eun-Sook Lee;Timothy Makumbi;Paul Ndom;Dong-Young Noh;Katie M. O’Brien;Oladosu Ojengbede;Andrew F. Olshan;Min-Ho Park;Sonya Reid;Taiki Yamaji;Gary Zirpoli;Ebonee N. Butler;Maosheng Huang;Siew-Kee Low;John Obafunwa;Clarice R. Weinberg;Haoyu Zhang;Hongyu Zhao;Michelle L. Cote;Christine B. Ambrosone;Dezheng Huo;Bingshan Li;Daehee Kang;Julie R. Palmer;Xiao-Ou Shu;Christopher A. Haiman;Xingyi Guo;Jirong Long;Wei Zheng - 通讯作者:
Wei Zheng
Proceedings of the fourth international molecular pathological epidemiology (MPE) meeting
- DOI:
10.1007/s10552-019-01177-z - 发表时间:
2019-05-08 - 期刊:
- 影响因子:2.100
- 作者:
Peter T. Campbell;Christine B. Ambrosone;Reiko Nishihara;Hugo J. W. L. Aerts;Melissa Bondy;Nilanjan Chatterjee;Montserrat Garcia-Closas;Marios Giannakis;Jeffrey A. Golden;Yujing J. Heng;N. Sertac Kip;Jill Koshiol;X. Shirley Liu;Camila M. Lopes-Ramos;Lorelei A. Mucci;Jonathan A. Nowak;Amanda I. Phipps;John Quackenbush;Robert E. Schoen;Lynette M. Sholl;Rulla M. Tamimi;Molin Wang;Matty P. Weijenberg;Catherine J. Wu;Kana Wu;Song Yao;Kun-Hsing Yu;Xuehong Zhang;Timothy R. Rebbeck;Shuji Ogino - 通讯作者:
Shuji Ogino
Christine B. Ambrosone的其他文献
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{{ truncateString('Christine B. Ambrosone', 18)}}的其他基金
Relationships between parity, breastfeeding and ER- breast cancer in African American women: Elucidating the biologic underpinnings at the molecular and cellular level.
非裔美国女性的产次、母乳喂养和 ER-乳腺癌之间的关系:阐明分子和细胞水平的生物学基础。
- 批准号:
10303040 - 财政年份:2018
- 资助金额:
$ 9.05万 - 项目类别:
Relationships between parity, breastfeeding and ER- breast cancer in African American women: Elucidating the biologic underpinnings at the molecular and cellular level.
非裔美国女性的产次、母乳喂养和 ER-乳腺癌之间的关系:阐明分子和细胞水平的生物学基础。
- 批准号:
10057367 - 财政年份:2018
- 资助金额:
$ 9.05万 - 项目类别:
Relationships between parity, breastfeeding and ER- breast cancer in African American women: Elucidating the biologic underpinnings at the molecular and cellular level.
非裔美国女性的产次、母乳喂养和 ER-乳腺癌之间的关系:阐明分子和细胞水平的生物学基础。
- 批准号:
10520028 - 财政年份:2018
- 资助金额:
$ 9.05万 - 项目类别:
Infrastructure for Pathways, a Prospective Study of Breast Cancer Survivorship
通路基础设施,乳腺癌存活率的前瞻性研究
- 批准号:
10622554 - 财政年份:2016
- 资助金额:
$ 9.05万 - 项目类别:
Infrastructure for Pathways, a Prospective Study of Breast Cancer Survivorship
通路基础设施,乳腺癌存活率的前瞻性研究
- 批准号:
10439575 - 财政年份:2016
- 资助金额:
$ 9.05万 - 项目类别:
Infrastructure for Pathways, a Prospective Study of Breast Cancer Survivorship
通路基础设施,乳腺癌存活率的前瞻性研究
- 批准号:
9044480 - 财政年份:2016
- 资助金额:
$ 9.05万 - 项目类别:
Infrastructure for Pathways, a Prospective Study of Breast Cancer Survivorship
通路基础设施,乳腺癌存活率的前瞻性研究
- 批准号:
9980180 - 财政年份:2016
- 资助金额:
$ 9.05万 - 项目类别:
Infrastructure for Pathways, a Prospective Study of Breast Cancer Survivorship
通路基础设施,乳腺癌存活率的前瞻性研究
- 批准号:
10081095 - 财政年份:2016
- 资助金额:
$ 9.05万 - 项目类别:
Invasive breast cancer with and without DCIS: Race, risk factors and outcomes
伴或不伴 DCIS 的浸润性乳腺癌:种族、危险因素和结果
- 批准号:
8512328 - 财政年份:2013
- 资助金额:
$ 9.05万 - 项目类别:
Epidemiology of Breast Cancer Subtypes in African American Women: a Consortium
非裔美国女性乳腺癌亚型的流行病学:一个联盟
- 批准号:
8523798 - 财政年份:2011
- 资助金额:
$ 9.05万 - 项目类别:
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