Epidemiology of Breast Cancer Subtypes in African American Women: a Consortium

非裔美国女性乳腺癌亚型的流行病学:一个联盟

基本信息

项目摘要

Women of African ancestry (AA) women are more likely than those with European ancestry (EA) to be diagnosed with breast cancer before age 45, and to have more aggressive tumors, characterized by high grade, with negative staining for estrogen and progesterone receptors and HER-2 (triple negative). They are also more likely to have basal-like breast tumors, an intrinsic breast cancer subtype with the poorest prognosis. The reasons for these disparities are unclear, and existing studies lack the statistical power to investigate risk factors for breast cancer subtypes among young women. In this Program Project, we will pool data and samples from the Carolina Breast Cancer Study (CBCS), the Black Women's Health Study (BWHS), the Women's Circle of Health Study (WCHS) and the Multi-ethnic Cohort (MEC) and continue to accrue cases for a final sample size of more than 5500 cases and 5500 controls. We will collect tissue blocks and classify cancers by their intrinsic subtypes, and investigate specific genetic, biologic and epidemiologic risk factors for subtypes in four highly interactive projects. The specific aims are to examine associations between age at diagnosis and breast cancer subtypes and 1) genetic loci identified in recent GWAS findings, using fine-mapping to identify potential causal alleles; 2) pregnancy history and lactation, and potential modification by genetic variants in related pathways; 3) body size, early life and adult physical activity, and gene/environment interactions; and 4) risk factors that may have been adaptive in Africa to endemic infectious disease (robust immune response) and intense sunlight (high skin pigmentation), but that in western society may result in hyper-inflammatory milieu and vitamin D deficiency, which may be related to early, aggressive breast cancer. Interactive aims will investigate relationships between subtypes and genetic and biologic factors, as well as epidemiologic characteristics. Cores that support all of the projects include the 1) Administrative Core; 2) Data Collection Core; 3) Biospecimen Core; and 4) Biostatistics and Data Management Core. By pooling our data, specimens, and importantly, expertise to investigate these synergist hypotheses, we will elucidate much of the etiology of aggressive, early onset breast cancers in AA women.
非洲血统 (AA) 女性比欧洲血统 (EA) 女性更有可能在 45 岁之前被诊断出患有乳腺癌,并且肿瘤更具侵袭性,其特点是恶性程度高,雌激素和孕激素受体以及 HER-2 呈阴性染色(三阴性)。他们也更有可能患有基底样乳腺肿瘤,这是一种预后最差的固有乳腺癌亚型。造成这些差异的原因尚不清楚,现有研究缺乏统计能力来调查年轻女性乳腺癌亚型的危险因素。在此计划项目中,我们将汇集来自卡罗莱纳州乳腺癌研究 (CBCS)、黑人女性健康研究 (BWHS)、女性健康圈研究 (WCHS) 和多种族队列 (MEC) 的数据和样本,并继续积累病例,最终样本量将超过 5500 例病例和 5500 例对照。我们将收集组织块并按其内在亚型对癌症进行分类,并在四个高度互动的项目中研究亚型的特定遗传、生物学和流行病学危险因素。具体目标是检查诊断年龄与乳腺癌亚型之间的关联,以及 1) 最近 GWAS 研究结果中确定的遗传位点,使用精细绘图来识别潜在的因果等位基因; 2) 妊娠史和哺乳史,以及相关途径中遗传变异的潜在修饰; 3) 体型、早期生命和成年体力活动以及基因/环境相互作用; 4)风险因素在非洲可能适应地方性传染病(强大的免疫反应)和强烈的阳光(高皮肤色素沉着),但在西方社会可能导致高炎症环境和维生素 D 缺乏,这可能与早期侵袭性乳腺癌有关。互动目标将调查亚型与遗传和生物因素以及流行病学特征之间的关系。支持所有项目的核心包括 1) 管理核心; 2)数据采集核心; 3) 生物样本核心; 4) 生物统计和数据管理核心。通过汇集我们的数据、样本以及重要的专业知识来研究这些协同剂假设,我们将阐明 AA 女性中侵袭性早发乳腺癌的大部分病因。

项目成果

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Christine B. Ambrosone其他文献

Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification
对超过 40 万名女性的分析为 BRCA1 和 BRCA2 变异分类提供了病例对照证据
  • DOI:
    10.1038/s41467-025-59979-6
  • 发表时间:
    2025-05-25
  • 期刊:
  • 影响因子:
    15.700
  • 作者:
    Maria Zanti;Denise G. O’Mahony;Michael T. Parsons;Leila Dorling;Joe Dennis;Nicholas J. Boddicker;Wenan Chen;Chunling Hu;Marc Naven;Kristia Yiangou;Thomas U. Ahearn;Christine B. Ambrosone;Irene L. Andrulis;Antonis C. Antoniou;Paul L. Auer;Caroline Baynes;Clara Bodelon;Natalia V. Bogdanova;Stig E. Bojesen;Manjeet K. Bolla;Kristen D. Brantley;Nicola J. Camp;Archie Campbell;Jose E. Castelao;Melissa H. Cessna;Jenny Chang-Claude;Fei Chen;Georgia Chenevix-Trench;Don M. Conroy;Kamila Czene;Arcangela De Nicolo;Susan M. Domchek;Thilo Dörk;Alison M. Dunning;A. Heather Eliassen;D. Gareth Evans;Peter A. Fasching;Jonine D. Figueroa;Henrik Flyger;Manuela Gago-Dominguez;Montserrat García-Closas;Gord Glendon;Anna González-Neira;Felix Grassmann;Andreas Hadjisavvas;Christopher A. Haiman;Ute Hamann;Steven N. Hart;Mikael B. A. Hartman;Weang-Kee Ho;James M. Hodge;Reiner Hoppe;Sacha J. Howell;Anna Jakubowska;Elza K. Khusnutdinova;Yon-Dschun Ko;Peter Kraft;Vessela N. Kristensen;James V. Lacey;Jingmei Li;Geok Hoon Lim;Sara Lindström;Artitaya Lophatananon;Craig Luccarini;Arto Mannermaa;Maria Elena Martinez;Dimitrios Mavroudis;Roger L. Milne;Kenneth Muir;Katherine L. Nathanson;Rocio Nuñez-Torres;Nadia Obi;Janet E. Olson;Julie R. Palmer;Mihalis I. Panayiotidis;Alpa V. Patel;Paul D. P. Pharoah;Eric C. Polley;Muhammad U. Rashid;Kathryn J. Ruddy;Emmanouil Saloustros;Elinor J. Sawyer;Marjanka K. Schmidt;Melissa C. Southey;Veronique Kiak-Mien Tan;Soo Hwang Teo;Lauren R. Teras;Diana Torres;Amy Trentham-Dietz;Thérèse Truong;Celine M. Vachon;Qin Wang;Jeffrey N. Weitzel;Siddhartha Yadav;Song Yao;Gary R. Zirpoli;Melissa S. Cline;Peter Devilee;Sean V. Tavtigian;David E. Goldgar;Fergus J. Couch;Douglas F. Easton;Amanda B. Spurdle;Kyriaki Michailidou
  • 通讯作者:
    Kyriaki Michailidou
Association between TP53 and p21 genetic polymorphisms and acute side effects of radiotherapy in breast cancer patients
  • DOI:
    10.1007/s10549-005-9119-2
  • 发表时间:
    2005-12-06
  • 期刊:
  • 影响因子:
    3.000
  • 作者:
    Xiang-Lin Tan;Odilia Popanda;Christine B. Ambrosone;Silke Kropp;Irmgard Helmbold;Dietrich von Fournier;Wulf Haase;Marie Luise Sautter-Bihl;Frederik Wenz;Peter Schmezer;Jenny Chang-Claude
  • 通讯作者:
    Jenny Chang-Claude
Erratum to: DNA hypermethylation and clinicopathological features in breast cancer: the Western New York Exposures and Breast Cancer (WEB) Study
  • DOI:
    10.1007/s10549-013-2660-5
  • 发表时间:
    2013-08-01
  • 期刊:
  • 影响因子:
    3.000
  • 作者:
    Meng Hua Tao;Peter G. Shields;Jing Nie;Amy Millen;Christine B. Ambrosone;Stephen B. Edge;Shiva S. Krishnan;Catalin Marian;Bin Xie;Janet Winston;Dominica Vito;Maurizio Trevisan;Jo L. Freudenheim
  • 通讯作者:
    Jo L. Freudenheim
Refining breast cancer genetic risk and biology through multi-ancestry fine-mapping analyses of 192 risk regions
通过对 192 个风险区域的多祖先精细定位分析来完善乳腺癌的遗传风险和生物学
  • DOI:
    10.1038/s41588-024-02031-y
  • 发表时间:
    2025-01-03
  • 期刊:
  • 影响因子:
    29.000
  • 作者:
    Guochong Jia;Zhishan Chen;Jie Ping;Qiuyin Cai;Ran Tao;Chao Li;Joshua A. Bauer;Yuhan Xie;Stefan Ambs;Mollie E. Barnard;Yu Chen;Ji-Yeob Choi;Yu-Tang Gao;Montserrat Garcia-Closas;Jian Gu;Jennifer J. Hu;Motoki Iwasaki;Esther M. John;Sun-Seog Kweon;Christopher I. Li;Koichi Matsuda;Keitaro Matsuo;Katherine L. Nathanson;Barbara Nemesure;Olufunmilayo I. Olopade;Tuya Pal;Sue K. Park;Boyoung Park;Michael F. Press;Maureen Sanderson;Dale P. Sandler;Chen-Yang Shen;Melissa A. Troester;Song Yao;Ying Zheng;Thomas Ahearn;Abenaa M. Brewster;Adeyinka Falusi;Anselm J. M. Hennis;Hidemi Ito;Michiaki Kubo;Eun-Sook Lee;Timothy Makumbi;Paul Ndom;Dong-Young Noh;Katie M. O’Brien;Oladosu Ojengbede;Andrew F. Olshan;Min-Ho Park;Sonya Reid;Taiki Yamaji;Gary Zirpoli;Ebonee N. Butler;Maosheng Huang;Siew-Kee Low;John Obafunwa;Clarice R. Weinberg;Haoyu Zhang;Hongyu Zhao;Michelle L. Cote;Christine B. Ambrosone;Dezheng Huo;Bingshan Li;Daehee Kang;Julie R. Palmer;Xiao-Ou Shu;Christopher A. Haiman;Xingyi Guo;Jirong Long;Wei Zheng
  • 通讯作者:
    Wei Zheng
Proceedings of the fourth international molecular pathological epidemiology (MPE) meeting
  • DOI:
    10.1007/s10552-019-01177-z
  • 发表时间:
    2019-05-08
  • 期刊:
  • 影响因子:
    2.100
  • 作者:
    Peter T. Campbell;Christine B. Ambrosone;Reiko Nishihara;Hugo J. W. L. Aerts;Melissa Bondy;Nilanjan Chatterjee;Montserrat Garcia-Closas;Marios Giannakis;Jeffrey A. Golden;Yujing J. Heng;N. Sertac Kip;Jill Koshiol;X. Shirley Liu;Camila M. Lopes-Ramos;Lorelei A. Mucci;Jonathan A. Nowak;Amanda I. Phipps;John Quackenbush;Robert E. Schoen;Lynette M. Sholl;Rulla M. Tamimi;Molin Wang;Matty P. Weijenberg;Catherine J. Wu;Kana Wu;Song Yao;Kun-Hsing Yu;Xuehong Zhang;Timothy R. Rebbeck;Shuji Ogino
  • 通讯作者:
    Shuji Ogino

Christine B. Ambrosone的其他文献

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{{ truncateString('Christine B. Ambrosone', 18)}}的其他基金

Relationships between parity, breastfeeding and ER- breast cancer in African American women: Elucidating the biologic underpinnings at the molecular and cellular level.
非裔美国女性的产次、母乳喂养和 ER-乳腺癌之间的关系:阐明分子和细胞水平的生物学基础。
  • 批准号:
    10303040
  • 财政年份:
    2018
  • 资助金额:
    $ 351.2万
  • 项目类别:
Relationships between parity, breastfeeding and ER- breast cancer in African American women: Elucidating the biologic underpinnings at the molecular and cellular level.
非裔美国女性的产次、母乳喂养和 ER-乳腺癌之间的关系:阐明分子和细胞水平的生物学基础。
  • 批准号:
    10057367
  • 财政年份:
    2018
  • 资助金额:
    $ 351.2万
  • 项目类别:
Relationships between parity, breastfeeding and ER- breast cancer in African American women: Elucidating the biologic underpinnings at the molecular and cellular level.
非裔美国女性的产次、母乳喂养和 ER-乳腺癌之间的关系:阐明分子和细胞水平的生物学基础。
  • 批准号:
    10520028
  • 财政年份:
    2018
  • 资助金额:
    $ 351.2万
  • 项目类别:
Infrastructure for Pathways, a Prospective Study of Breast Cancer Survivorship
通路基础设施,乳腺癌存活率的前瞻性研究
  • 批准号:
    10622554
  • 财政年份:
    2016
  • 资助金额:
    $ 351.2万
  • 项目类别:
Infrastructure for Pathways, a Prospective Study of Breast Cancer Survivorship
通路基础设施,乳腺癌存活率的前瞻性研究
  • 批准号:
    10439575
  • 财政年份:
    2016
  • 资助金额:
    $ 351.2万
  • 项目类别:
Infrastructure for Pathways, a Prospective Study of Breast Cancer Survivorship
通路基础设施,乳腺癌存活率的前瞻性研究
  • 批准号:
    9044480
  • 财政年份:
    2016
  • 资助金额:
    $ 351.2万
  • 项目类别:
Infrastructure for Pathways, a Prospective Study of Breast Cancer Survivorship
通路基础设施,乳腺癌存活率的前瞻性研究
  • 批准号:
    9980180
  • 财政年份:
    2016
  • 资助金额:
    $ 351.2万
  • 项目类别:
Infrastructure for Pathways, a Prospective Study of Breast Cancer Survivorship
通路基础设施,乳腺癌存活率的前瞻性研究
  • 批准号:
    10081095
  • 财政年份:
    2016
  • 资助金额:
    $ 351.2万
  • 项目类别:
Invasive breast cancer with and without DCIS: Race, risk factors and outcomes
伴或不伴 DCIS 的浸润性乳腺癌:种族、危险因素和结果
  • 批准号:
    8512328
  • 财政年份:
    2013
  • 资助金额:
    $ 351.2万
  • 项目类别:
Invasive breast cancer with and without DCIS: Race, risk factors and outcomes
伴或不伴 DCIS 的浸润性乳腺癌:种族、危险因素和结果
  • 批准号:
    8634076
  • 财政年份:
    2013
  • 资助金额:
    $ 351.2万
  • 项目类别:

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