Bioinfornnatics Core

对于这个项目，我们将建立一个生物信息学核心来处理和分析大量的 将由其四个项目生成的数据。我们建议对基因组维护进行比较研究 以及与啮齿动物衰老有关的肿瘤抑制。虽然长期以来人们观察到啮齿动物不同 在他们的一生中，这种差异背后的机制仍然不清楚。缺乏这种能力 信息是一个重要的问题，因为在没有这些知识的情况下，获得调节衰老的能力 从整个生物体层面来看，这是极不可能的。我们的长期目标是了解 决定长寿。生物信息学核心的总体目标是提供计算支持和 为项目调查人员提供服务-即既与每个项目合作，处理其中产生的数据 并整合所有项目的数据，以实现计划项目拨款的整体目标。这个 这个计划的中心假设是长寿的啮齿动物进化出了特定的分子机制 以此来调节它们的寿命。这个假设是在初步数据的基础上提出的 在申请者的实验室里。一个专门的生物信息学核心的基本原理是，一个整合的设施 需要管理整个基因组水平上的大量数据，这些数据分别由四个高度 本计划项目的综合项目。这个生物信息学核心的建立将实现三个目标 具体目标：1)开发一个网络门户来存储和共享项目产生的数据；2) 促进项目处理和分析其生成的数据；3)在 系统水平和识别与寿命控制相关的遗传网络。生物信息学核心的功能 意义重大，因为它的设置是为了应对需要 通过各种方法在多个层次上进行生成、检查、集成以开发 寿命控制，并在项目调查人员之间共享。 相关性(见说明)； 拟议的生物信息学核心与公共卫生有关，因为Web数据门户和新颖的 计算方法，将被开发来解决巨大差异背后的遗传基础 在啮齿动物的寿命中，数据也将被用来向更大的研究界传播数据。这个 拟议的研究与国家图书馆-L的使命相关，因为它与发展基础知识有关 这将有助于减轻与高龄相关的人类残疾的负担。

For this program project, we will establish a bioinformatics core to process and analyze the large amount of data that will be generated by its four projects. We propose a comparative study of genome maintenance and tumor suppression in relation to aging in rodents. While it has long been observed that rodents differ enormously in their life spans, the mechanisms behind this difference remain unclear. Lack of this information is an important problem, because, without this knowledge, acquiring the ability to modulate aging on the whole organism level is highly unlikely. Our long-term goal is to understand the mechanisms that determine longevity. The overall objective of the bioinformatics core is to provide computational support and service to the project investigators - namely, both to work with each project to handle data generated therein and to integrate data from all projects to achieve the aims of the program project grant as a whole. The central hvpothesis of this Program is that long-lived rodents have evolved specific molecular mechanisms that mediate their longevity. This hypothesis has been formulated on the basis of preliminary data produced in the applicants' laboratories. The rationale for a dedicated bioinformatics core is that a consolidated facility is needed to manage the large amount of data on the whole genome level generated by each of four highly integrated projects of this program project. This bioinformatics core will be established to achieve three specific aims: 1) To deveipp a Web portal to warehouse and share data generated by projects; 2) To facilitate projects to process and analyze the data that they generate; 3) To integrate project data at the systems level and identify genetic network related to life span control. The function of the bioinformatics core is significant, because it will be set up to meet the challenge posed by the high volume of data that need to be generated, examined at multiple levels by a variety of approaches, integrated to develop the models of lifespan control, and shared among project investigators. RELEVANCE (See instructions); The proposed bioinformatics core is relevant to public health because the Web data portal and novel computational methods, which will be developed to tackle the genetic bases behind the enormous difference in life span among rodents, will also be used to disseminate the data to the larger research community. The proposed research is relevant to the Nll-l's mission in that it pertains to developing fundamental knowledge that will help reduce the burdens of human disability associated with advanced age.