Data Integration and Sharing Core

项目总结/摘要 对于U19项目，我们将建立一个数据集成与共享（DIS）核心来处理和分析 它的四个研究项目将产生大量的数据。U19提出了一个集成的 该研究旨在测试开发年龄相关疾病治疗方法的新方法。而不是专注于 个别疾病，我们探索成功的老年人，健康的百岁老人和控制之间的遗传差异 没有极端长寿家族史的人。我们的长期目标是利用发现的基因变异， 在百岁老人的基因组中，作为开发药物的潜在目标，可以预防，延缓发病和进展， 甚至有可能逆转许多与年龄有关的疾病。综合安全分遣队核心的总体目标是 为项目调查人员提供一个计算和统计平台，以分析和共享他们的数据 从而实现U19项目赠款的目标。U19的核心假设是， 百岁老人在保守的衰老途径中具有罕见变异的保护性基因型，这些基因型可用于 确定新的药物靶点，作为随后开发针对多种年龄相关疾病的治疗方法的基础 疾病，并最终增加人类的健康。这一假设是基于一个大的 已经在U19中生成的数据主体。为此目的设立一个专用核心的理由是， 需要一个统一的设施来管理大量的全基因组水平的数据， 这是U19的四个高度集成的项目。该DIS核心将实现三个具体目标 目的：1）协助项目处理和分析他们产生的数据; 2）整合项目数据 在系统一级，并确定长寿药物靶点的遗传网络; 3）开发一个门户网站， 仓库和共享项目生成的数据。DIS Core的功能非常重要，因为它将 建立该系统的目的是为了应对需要生成、检查和 多层次的各种方法，集成开发模型的寿命控制，并共享 在项目调查人员和科学界中广泛传播。

PROJECT SUMMARY/ABSTRACT For this U19 Program Project, we will establish a Data Integration and Sharing (DIS) Core to process and analyze the large amount of data that will be generated by its four research projects. This U19 proposes an integrated study to test a new approach for developing therapies for age-related diseases. Rather than focusing on individual diseases, we explore genetic differences between successfully aged, healthy centenarians and control individuals with no family history of extreme longevity. Our long-term goal is to use gene variants found enriched in the centenarian genome as potential targets for developing drugs that prevent, delay onset and progression, and possibly even revert many of the multiple age-related diseases. The overall objective of the DIS core is to provide a computational and statistical platform to the project investigators for analyzing and sharing their data in concert, thereby achieving the aims of the U19 project grant. The central hypothesis of this U19 is that centenarians harbor protective genotypes of rare variants in conserved aging pathways, which can be used to identify novel drug targets as the basis for subsequent development of therapeutics against multiple age-related diseases and to ultimately increase human healthspan. This hypothesis has been formulated based on a large body of data already produced in this U19. The rationale for a dedicated core to that purpose is that a consolidated facility is needed to manage the large amount of data on the whole genome level generated by each of four highly integrated projects of this U19. This DIS Core will be established to achieve three specific aims: 1) To assist projects in processing and analyzing the data that they generate; 2) To integrate project data at the systems level and identify genetic network of pro-longevity drug targets; 3) To develop a web portal to warehouse and share data generated by the projects. The function of the DIS Core is significant, because it will be set up to meet the challenge posed by the high volume of data that need to be generated, examined at multiple levels by a variety of approaches, integrated to develop the models for lifespan control, and shared among project investigators and the scientific community at large.