Data Integration and Sharing Core

项目摘要/摘要 对于这个U19项目，我们将建立一个数据集成和共享(DIS)核心来处理和分析 它的四个研究项目将产生大量数据。这款U19提出了一种集成的 旨在测试开发治疗年龄相关疾病的新方法的研究。与其把重点放在 单个疾病，我们探索成功老龄化、健康的百岁老人和对照组之间的遗传差异。 没有超长寿家族史的个人。我们的长期目标是利用已发现的丰富的基因变异 在百岁老人基因组中，作为开发预防、延缓发病和进展的药物的潜在靶点， 甚至可能逆转许多与年龄相关的多种疾病。综合安全分遣队核心的总体目标是 为项目调查人员提供计算和统计平台，以分析和共享他们的数据 协调一致，从而实现U19项目赠款的目标。这个U19的中心假设是 百岁老人在保守的衰老途径中拥有稀有变异的保护性基因类型，这可以用来 确定新的药物靶点作为后续开发治疗多发性年龄相关性疾病的基础 并最终增加人类的健康寿命。这一假说是基于一个大型的 已在本U19中生成的数据体。为此目的而设立专用核心的理由是， 需要整合的设施来管理整个基因组水平上的大量数据 这款U19的四个高度集成的项目中的每一个。建立这一DIS核心将实现三个具体目标 目标：1)协助项目处理和分析其生成的数据；2)整合项目数据 在系统层面并确定长寿药物靶点的遗传网络；3)开发一个门户网站，以 存储和共享项目生成的数据。DIS核心的功能非常重要，因为它将 为应对需要生成的大量数据带来的挑战而设置，请查看 通过多种方法的多个级别，集成以开发寿命控制模型，并共享 在项目调查人员和整个科学界之间。

PROJECT SUMMARY/ABSTRACT For this U19 Program Project, we will establish a Data Integration and Sharing (DIS) Core to process and analyze the large amount of data that will be generated by its four research projects. This U19 proposes an integrated study to test a new approach for developing therapies for age-related diseases. Rather than focusing on individual diseases, we explore genetic differences between successfully aged, healthy centenarians and control individuals with no family history of extreme longevity. Our long-term goal is to use gene variants found enriched in the centenarian genome as potential targets for developing drugs that prevent, delay onset and progression, and possibly even revert many of the multiple age-related diseases. The overall objective of the DIS core is to provide a computational and statistical platform to the project investigators for analyzing and sharing their data in concert, thereby achieving the aims of the U19 project grant. The central hypothesis of this U19 is that centenarians harbor protective genotypes of rare variants in conserved aging pathways, which can be used to identify novel drug targets as the basis for subsequent development of therapeutics against multiple age-related diseases and to ultimately increase human healthspan. This hypothesis has been formulated based on a large body of data already produced in this U19. The rationale for a dedicated core to that purpose is that a consolidated facility is needed to manage the large amount of data on the whole genome level generated by each of four highly integrated projects of this U19. This DIS Core will be established to achieve three specific aims: 1) To assist projects in processing and analyzing the data that they generate; 2) To integrate project data at the systems level and identify genetic network of pro-longevity drug targets; 3) To develop a web portal to warehouse and share data generated by the projects. The function of the DIS Core is significant, because it will be set up to meet the challenge posed by the high volume of data that need to be generated, examined at multiple levels by a variety of approaches, integrated to develop the models for lifespan control, and shared among project investigators and the scientific community at large.