Integrating social networks through amygdalostriatal paths

描述（由申请人提供）：通过杏仁核纹状体路径整合社会网络我们实验室长期关注的焦点是通过灵长类动物杏仁核确定介导严重精神疾病症状的途径。由于精神综合症中的情绪失调通常表现为社会功能失调，因此拟议的研究考察了涉及社会功能的网络如何与非人灵长类动物杏仁核和纹状体中的“显著性检测”途径相互作用。非人灵长类动物的神经道追踪研究可以更准确地解释人类的神经成像结果，并且是在细胞水平上理解灵长类动物大脑结构细节的关键桥梁。在这组研究中，我们研究了在精神疾病中经常失调的两个皮质网络：“显著性检测”网络（25/32区，颗粒岛），它监测内部生理状态以“标记”显著性线索，以及“社会监测”网络（24/14区/非颗粒皮质），它检测和解释他人行为的意义和价值。这些网络通常被认为是生理上不同的。然而，由于人类疾病中的情绪失调经常表现为对社会线索的误解，因此必须存在“突出”和“社会监测”网络的整合。我们提出，通过杏仁核和纹状体的特定回路是这种整合的基础。目标1将绘制杏仁核中“社会监控相关”皮层输入的边界，以及输出到纹状体的结果组织。在第二项研究中，我们将把逆行示踪剂放置在第一项研究中“社会”皮质杏仁体-纹状体路径的新纹状体区域，以确定它们是否由来自社会监测网络的直接皮层投影定义。在目标3中，我们将在更高的功率下检查杏仁核，以确定来自“突出性”和“社会监测”网络节点的汇聚输入终端是否主要在相同的神经群上突触，还是在单独的亚群上突触。

DESCRIPTION (provided by applicant): Integrating social networks through amygdalostriatal paths A longstanding focus of our laboratory is the identification of pathways through the primate amygdala that are positioned to mediate symptomatology of severe mental illnesses. Because emotional dysregulation in psychiatric syndromes is often expressed as maladaptive social function, the proposed studies examine how networks involved in social function interact with 'salience detection' pathways in the amygdala and striatum of the nonhuman primate. Tract tracing studies in nonhuman primate enable more accurate interpretation of neuroimaging results in humans, and are a critical bridge for understanding details of primate brain structure on a cellular level. In this set of studies, we examine two cortical networks that are frequently dysregulated in psychiatric illnesses: the 'salience detection' network (areas 25/32, agranular insula) which monitors internal physiologic states to 'mark' salient cues, and the 'social monitoring' network (areas 24/14/dysgranular cortex), which detects and interprets the meaning and value of others' actions. These networks are often considered physiologically distinct. However, since emotional dysregulation in human illness is frequently expressed in misinterpretation of social cues, integration of 'salience' and 'social monitoring' networks must exist. We propose that specific circuits through the amygdala and striatum are substrates for this integration. Aim 1 will map the boundaries of inputs from 'social-monitoring-associated' cortex in the amygdala, and the resulting organization of outputs to the striatum. In Aim 2, we will place retrograde tracers into novel striatal sectors targeted by 'social' corticoamygdala-striatal path in Aim 1 to determine whether they are defined by direct cortical projections from the social monitoring network. In Aim 3 we will examine the amygdala under higher power, to determine whether converging inputs terminals from nodes of the 'salience' and 'social monitoring' networks predominantly synapse on the same neural population, or on separate subpopulations.