Integrating social networks through amygdalostriatal paths

通过杏仁核纹状体路径整合社交网络

• 批准号: 8800657
• 负责人: JULIE L. FUDGE
• 金额: $ 45.99万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-16 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8800657
• 关键词: Amygdaloid structure; Anatomy; Animals; Anxiety; Area; Autistic Disorder; Basal Ganglia; Brain; Brain region; Cell Nucleus; Cells; Cognitive; Confocal Microscopy; Corpus striatum structure; Cues; Detection; Emotional; Emotions; Fiber; Figs - dietary; Human; Injection of therapeutic agent; Insula of Reil; Label; Laboratories; Light Microscope; Maps; Mediating; Microscopic; Monitor; Neurons; Output; Pathway interactions; Patients; Physiological; Play; Population; Positioning Attribute; Prefrontal Cortex; Primates; Psychotic Disorders; Role; Social Concepts; Social Functioning; Social Network; Structure; Synapses; Syndrome; Tracer; Undifferentiated; Ventral Striatum; motivated behavior; neuroimaging; nonhuman primate; novel; public health relevance; putamen; relating to nervous system; segregation; severe mental illness; social

DESCRIPTION (provided by applicant): Integrating social networks through amygdalostriatal paths A longstanding focus of our laboratory is the identification of pathways through the primate amygdala that are positioned to mediate symptomatology of severe mental illnesses. Because emotional dysregulation in psychiatric syndromes is often expressed as maladaptive social function, the proposed studies examine how networks involved in social function interact with 'salience detection' pathways in the amygdala and striatum of the nonhuman primate. Tract tracing studies in nonhuman primate enable more accurate interpretation of neuroimaging results in humans, and are a critical bridge for understanding details of primate brain structure on a cellular level. In this set of studies, we examine two cortical networks that are frequently dysregulated in psychiatric illnesses: the 'salience detection' network (areas 25/32, agranular insula) which monitors internal physiologic states to 'mark' salient cues, and the 'social monitoring' network (areas 24/14/dysgranular cortex), which detects and interprets the meaning and value of others' actions. These networks are often considered physiologically distinct. However, since emotional dysregulation in human illness is frequently expressed in misinterpretation of social cues, integration of 'salience' and 'social monitoring' networks must exist. We propose that specific circuits through the amygdala and striatum are substrates for this integration. Aim 1 will map the boundaries of inputs from 'social-monitoring-associated' cortex in the amygdala, and the resulting organization of outputs to the striatum. In Aim 2, we will place retrograde tracers into novel striatal sectors targeted by 'social' corticoamygdala-striatal path in Aim 1 to determine whether they are defined by direct cortical projections from the social monitoring network. In Aim 3 we will examine the amygdala under higher power, to determine whether converging inputs terminals from nodes of the 'salience' and 'social monitoring' networks predominantly synapse on the same neural population, or on separate subpopulations.

描述（由申请人提供）：通过杏仁核纹状体路径整合社交网络我们实验室的长期重点是识别通过灵长类杏仁核的路径，这些路径可调节严重精神疾病的症状。由于精神综合症中的情绪失调通常表现为适应不良的社会功能，因此拟议的研究探讨了参与社会功能的网络如何与非人类灵长类动物的杏仁核和纹状体中的“显着性检测”通路相互作用。非人类灵长类动物的神经束追踪研究能够更准确地解释人类的神经影像结果，并且是在细胞水平上了解灵长类动物大脑结构细节的关键桥梁。在这组研究中，我们检查了在精神疾病中经常失调的两个皮质网络：“显着性检测”网络（区域 25/32，粒状岛叶），其监测内部生理状态以“标记”显着线索；以及“社会监控”网络（区域 24/14/颗粒状皮质），其检测并解释他人行为的意义和价值。这些网络通常被认为在生理上是不同的。然而，由于人类疾病中的情绪失调经常表现为对社会线索的误解，因此必须存在“显着性”和“社会监控”网络的整合。我们提出，通过杏仁核和纹状体的特定回路是这种整合的基础。目标 1 将绘制杏仁核“社交监控相关”皮层输入的边界，以及由此产生的纹状体输出组织。在目标 2 中，我们将把逆行示踪剂放入目标 1 中“社会”皮质杏仁核-纹状体路径所针对的新纹状体区域，以确定它们是否是由社会监测网络的直接皮质投影定义的。在目标 3 中，我们将在更高功率下检查杏仁核，以确定来自“显着性”和“社会监控”网络节点的汇聚输入终端是否主要在同一神经群体或不同的子群体上突触。