Integrating social networks through amygdalostriatal paths

通过杏仁核纹状体路径整合社交网络

• 批准号: 9275017
• 负责人: JULIE L. FUDGE
• 金额: $ 36.44万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-16 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9275017
• 关键词: Amygdaloid structure; Anatomy; Animals; Anxiety; Area; Autistic Disorder; Basal Ganglia; Brain; Brain region; Cell Nucleus; Cells; Cognitive; Confocal Microscopy; Corpus striatum structure; Cues; Detection; Emotional; Emotions; Fiber; Human; Injection of therapeutic agent; Insula of Reil; Label; Laboratories; Light Microscope; Maps; Mediating; Mental disorders; Microscopic; Monitor; Neurons; Organizational Productivity; Output; Pathway interactions; Patients; Physiological; Play; Population; Positioning Attribute; Prefrontal Cortex; Primates; Psychotic Disorders; Role; Social Concepts; Social Functioning; Social Network; Structure; Synapses; Syndrome; Tracer; Undifferentiated; Ventral Striatum; emotion dysregulation; motivated behavior; neuroimaging; nonhuman primate; novel; public health relevance; putamen; relating to nervous system; segregation; severe mental illness; social; symptomatology

DESCRIPTION (provided by applicant): Integrating social networks through amygdalostriatal paths A longstanding focus of our laboratory is the identification of pathways through the primate amygdala that are positioned to mediate symptomatology of severe mental illnesses. Because emotional dysregulation in psychiatric syndromes is often expressed as maladaptive social function, the proposed studies examine how networks involved in social function interact with 'salience detection' pathways in the amygdala and striatum of the nonhuman primate. Tract tracing studies in nonhuman primate enable more accurate interpretation of neuroimaging results in humans, and are a critical bridge for understanding details of primate brain structure on a cellular level. In this set of studies, we examine two cortical networks that are frequently dysregulated in psychiatric illnesses: the 'salience detection' network (areas 25/32, agranular insula) which monitors internal physiologic states to 'mark' salient cues, and the 'social monitoring' network (areas 24/14/dysgranular cortex), which detects and interprets the meaning and value of others' actions. These networks are often considered physiologically distinct. However, since emotional dysregulation in human illness is frequently expressed in misinterpretation of social cues, integration of 'salience' and 'social monitoring' networks must exist. We propose that specific circuits through the amygdala and striatum are substrates for this integration. Aim 1 will map the boundaries of inputs from 'social-monitoring-associated' cortex in the amygdala, and the resulting organization of outputs to the striatum. In Aim 2, we will place retrograde tracers into novel striatal sectors targeted by 'social' corticoamygdala-striatal path in Aim 1 to determine whether they are defined by direct cortical projections from the social monitoring network. In Aim 3 we will examine the amygdala under higher power, to determine whether converging inputs terminals from nodes of the 'salience' and 'social monitoring' networks predominantly synapse on the same neural population, or on separate subpopulations.

描述（申请人提供）：通过杏仁核纹状体路径整合社交网络我们实验室长期以来的重点是识别通过灵长类动物杏仁核的路径，这些路径被定位为介导严重精神疾病的神经病学。由于精神综合征中的情绪失调通常表现为适应不良的社会功能，因此拟议的研究将研究参与社会功能的网络如何与非人类灵长类动物杏仁核和纹状体中的“显着性检测”通路相互作用。在非人灵长类动物中进行的神经束追踪研究能够更准确地解释人类的神经成像结果，并且是在细胞水平上了解灵长类动物大脑结构细节的关键桥梁。在这组研究中，我们检查了两个在精神疾病中经常失调的皮层网络：“显着性检测”网络（区域25/32，无颗粒皮层），它监测内部生理状态以“标记”显着线索，以及“社会监测”网络（区域24/14/异常颗粒皮层），它检测和解释他人行为的意义和价值。这些网络通常被认为是生理上不同的。然而，由于人类疾病中的情绪失调经常表现为对社会线索的误解，因此必须存在“显着性”和“社会监测”网络的整合。我们认为，通过杏仁核和纹状体的特定电路是这种整合的基板。目标1将绘制来自杏仁核中“社会监控相关”皮层的输入边界，以及由此产生的对纹状体输出的组织。在目标2中，我们将把逆行示踪剂到新的纹状体部门的目标1中的“社会”皮质杏仁核-纹状体路径为目标，以确定它们是否被定义为从社会监测网络的直接皮质预测。在目标3中，我们将在更高的功率下检查杏仁核，以确定来自“显着性”和“社会监控”网络节点的收敛输入终端是否主要在同一神经群体上或在单独的亚群上突触。