Integrating social networks through amygdalostriatal paths

通过杏仁核纹状体路径整合社交网络

• 批准号: 9275017
• 负责人: JULIE L. FUDGE
• 金额: $ 36.44万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-16 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9275017
• 关键词: Amygdaloid structure; Anatomy; Animals; Anxiety; Area; Autistic Disorder; Basal Ganglia; Brain; Brain region; Cell Nucleus; Cells; Cognitive; Confocal Microscopy; Corpus striatum structure; Cues; Detection; Emotional; Emotions; Fiber; Human; Injection of therapeutic agent; Insula of Reil; Label; Laboratories; Light Microscope; Maps; Mediating; Mental disorders; Microscopic; Monitor; Neurons; Organizational Productivity; Output; Pathway interactions; Patients; Physiological; Play; Population; Positioning Attribute; Prefrontal Cortex; Primates; Psychotic Disorders; Role; Social Concepts; Social Functioning; Social Network; Structure; Synapses; Syndrome; Tracer; Undifferentiated; Ventral Striatum; emotion dysregulation; motivated behavior; neuroimaging; nonhuman primate; novel; public health relevance; putamen; relating to nervous system; segregation; severe mental illness; social; symptomatology

DESCRIPTION (provided by applicant): Integrating social networks through amygdalostriatal paths A longstanding focus of our laboratory is the identification of pathways through the primate amygdala that are positioned to mediate symptomatology of severe mental illnesses. Because emotional dysregulation in psychiatric syndromes is often expressed as maladaptive social function, the proposed studies examine how networks involved in social function interact with 'salience detection' pathways in the amygdala and striatum of the nonhuman primate. Tract tracing studies in nonhuman primate enable more accurate interpretation of neuroimaging results in humans, and are a critical bridge for understanding details of primate brain structure on a cellular level. In this set of studies, we examine two cortical networks that are frequently dysregulated in psychiatric illnesses: the 'salience detection' network (areas 25/32, agranular insula) which monitors internal physiologic states to 'mark' salient cues, and the 'social monitoring' network (areas 24/14/dysgranular cortex), which detects and interprets the meaning and value of others' actions. These networks are often considered physiologically distinct. However, since emotional dysregulation in human illness is frequently expressed in misinterpretation of social cues, integration of 'salience' and 'social monitoring' networks must exist. We propose that specific circuits through the amygdala and striatum are substrates for this integration. Aim 1 will map the boundaries of inputs from 'social-monitoring-associated' cortex in the amygdala, and the resulting organization of outputs to the striatum. In Aim 2, we will place retrograde tracers into novel striatal sectors targeted by 'social' corticoamygdala-striatal path in Aim 1 to determine whether they are defined by direct cortical projections from the social monitoring network. In Aim 3 we will examine the amygdala under higher power, to determine whether converging inputs terminals from nodes of the 'salience' and 'social monitoring' networks predominantly synapse on the same neural population, or on separate subpopulations.

描述(申请人提供)：通过杏仁纹状体路径整合社交网络我们实验室的一个长期重点是识别通过灵长类杏仁核的路径，这些路径被定位为调节严重精神疾病的症状。由于精神疾病综合征中的情绪失调通常表现为社会功能不适应，因此拟议中的研究考察了参与社会功能的网络如何与非人类灵长类动物杏仁核和纹状体中的“显著检测”通路相互作用。非人灵长类动物的轨迹追踪研究能够更准确地解释人类的神经成像结果，是在细胞水平上理解灵长类动物大脑结构细节的关键桥梁。在这组研究中，我们研究了两个在精神疾病中经常失调的皮质网络：监测内部生理状态以对突出线索进行标记的“显著检测”网络(25/32区，无颗粒脑岛)和检测和解释他人行为的意义和价值的“社会监测”网络(24/14区/颗粒皮质)。这些网络通常被认为在生理上是不同的。然而，由于人类疾病中的情绪失调经常表现为对社会线索的曲解，因此必须存在“突出”和“社会监控”网络的整合。我们认为，通过杏仁核和纹状体的特定回路是这种整合的底物。目标1将绘制杏仁核“社会监控相关”皮质的输入边界，以及纹状体输出的结果组织。在目标2中，我们将把逆行示踪剂放入目标1中以“社会”杏仁核-纹状体路径为目标的新的纹状体区域，以确定它们是否由社会监测网络的直接皮质投射所定义。在目标3中，我们将研究更高功率下的杏仁核，以确定来自‘突出’和‘社会监控’网络节点的汇聚输入终端主要是在同一神经群体上突触，还是在不同的亚群上突触。