Traumatic Bridging Vein Failure in Infants

婴儿外伤性桥静脉衰竭

• 批准号: 8769696
• 负责人: Susan Sheps Margulies
• 金额: $ 23.47万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-08 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8769696
• 关键词: Acceleration; Accidental Falls; Acute; Adult; Age; Animal Experiments; Animals; Applications Grants; Archives; Basic Science; Biomechanics; Brain; Brain Injuries; Cause of Death; Cerebrum; Child; Childhood; Childhood Injury; Cognitive deficits; Computer Simulation; Craniocerebral Trauma; Data; Dependence; Development; Diagnostic; Differential Diagnosis; Diffuse Axonal Injury; Elements; Ensure; Etiology; Event; Failure; Family suidae; Fatigue; Finite Element Analysis; Foundations; Future; Goals; Head; Head Movements; Hemorrhage; Household; Human; Incidence; Infant; Injury; Lead; Legal; Life; Measures; Mechanics; Medical; Modeling; Motion; Outcome; Patients; Positioning Attribute; Prevention strategy; Probability; Procedures; Property; Publishing; Records; Research; Rotation; Rupture; Sensitivity and Specificity; Simulate; Stress; Stretching; Subarachnoid Hemorrhage; Subdural Hematoma; Surface; Surgical sutures; Testing; Time; Tissues; Traumatic Brain Injury; Validation; Veins; age related; clinical Diagnosis; cranium; data modeling; experience; falls; immature animal; injury prevention; instrument; kinematics; models and simulation; prospective; public health relevance; research study; simulation

DESCRIPTION (provided by applicant): Traumatic brain injury (TBI) is the most common cause of death in childhood. Extra-axial hemorrhage (EAH, which includes subdural and subarachnoid hemorrhage) carries additional medical-legal significance, as it is often used to distinguish between accidental and abusive injury etiologies in young children. Although EAH is generally thought to occur from tearing of bridging veins (BVs) and/or cortical vessels, there is a paucity of data about the age dependence of BV properties, as well as the relationship between number of vessels ruptured and extent of EAH. In this proposal to investigate TBI mechanisms specific to young children, our hypotheses are that rapid rotations of the immature head can produce BV failure, that the biomechanical BV properties of the infant will reveal lower BV rupture stress and strain than the adult, conferring a vulnerability for BV rupture to the infant. n addition, we hypothesize that cyclic elongation will soften the BVs, rendering them more fragile with repeated head rotations than single events. With expertise in biomechanical testing and finite element analysis, and archived data from patient studies, animal experiments and anthropomorphic doll simulations of accidental and abusive TBI events, we are uniquely poised to determine the mechanisms associated with EAH in TBI. In this exploratory R21 grant application, our 2-year goal is to leverage these previous discoveries with new experiments to identify the mechanisms of traumatic EAH in children. In just two years, we will be the first to determine mechanical properties of pediatric BVs (Aim 1); integrate them into computational finite element models (FEMs) for EAH prediction, and validate the predictive capabilities of our procedures (Aim 2); and use the FEMs to identify EAH potential in single and cyclic head movements (Aim 3). Taken together, the results of this basic research plan will provide the scientific foundation for the development of new strategies for injury prevention, clinical diagnosis, and injury mitigation to reduce the number of children with new debilitating TBIs each year.

描述（由申请人提供）：创伤性脑损伤（TBI）是儿童最常见的死亡原因。轴外出血（EAH，包括硬膜下和蛛网膜下腔出血）具有额外的医学法律意义，因为它通常用于区分幼儿意外和虐待性伤害的病因。虽然EAH通常被认为是由桥静脉（BVs）和/或皮质血管撕裂引起的，但也存在一些不确定因素