MONITORING PEDIATRIC HEAD INJURY MODELS IN PIGLETS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在美国，创伤性脑损伤是儿童发病率和死亡率的主要原因。 每年每100,000名需要住院的儿童中约有200人需要住院。 货币成本的增加不仅是因为对这些患者的急性重症监护，而且 此外，还需要长期护理，这往往是必要的。这些患者的脑损伤是由这两种原因造成的 原发创伤和二次伤害，如脑血流减少，精神错乱 在大脑新陈代谢方面，以及随后的缺血性损伤，在 创伤性事件。因此，最佳的治疗效果需要了解脑血流、氧气 颅脑损伤后患者的供氧量和氧耗量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Traumatic brain injury (TBI) is a leading cause of childhood morbidity and mortality in the United States, with an annual rate of approximately 200 per 100,000 children requiring hospitalization. The increasing monetary costs result not only from the acute intensive care for these patients but also from long-term care that is often necessary. Brain injuries in these patients result from both the primary trauma and secondary insults such as reductions in cerebral blood flow, derangements in cerebral metabolism, and the ensuing ischemic injuries that continue to progress well after the traumatic event. Optimal therapeutic efficacy thus requires knowledge of cerebral blood flow, oxygen supply, and oxygen consumption in patients after TBI.