MONITORING PEDIATRIC HEAD INJURY MODELS IN PIGLETS

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 创伤性脑损伤（TBI）是美国儿童发病率和死亡率的主要原因。 每年每10万名儿童中约有200人需要住院治疗。 不断增加的货币成本不仅来自对这些患者的急性重症监护， 长期护理也是必要的。这些患者的脑损伤是由两种原因造成的 原发性创伤和继发性损伤，如脑血流量减少、神经紊乱 在脑代谢中，以及随后的缺血性损伤在脑缺血后继续发展， 创伤性事件因此，最佳的治疗效果需要了解脑血流、氧气 TBI后患者的氧供应和氧消耗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Traumatic brain injury (TBI) is a leading cause of childhood morbidity and mortality in the United States, with an annual rate of approximately 200 per 100,000 children requiring hospitalization. The increasing monetary costs result not only from the acute intensive care for these patients but also from long-term care that is often necessary. Brain injuries in these patients result from both the primary trauma and secondary insults such as reductions in cerebral blood flow, derangements in cerebral metabolism, and the ensuing ischemic injuries that continue to progress well after the traumatic event. Optimal therapeutic efficacy thus requires knowledge of cerebral blood flow, oxygen supply, and oxygen consumption in patients after TBI.