Interactive Technology for Pediatric HIV/AIDS Treatment Adherence

促进儿童艾滋病毒/艾滋病治疗依从性的互动技术

• 批准号: 8790283
• 负责人: Amanda Derryck Castel
• 金额: $ 35万
• 依托单位: MEDIA REZ, LLC
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-24 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8790283
• 关键词: AIDS prevention; AIDS/HIV problem; Accounting; Adherence; Adolescent; Adolescent and Young Adult; Age; Anti-Retroviral Agents; Arts; Attitude; Behavior Therapy; Behavioral; Biological; CD4 Lymphocyte Count; Caring; Centers for Disease Control and Prevention (U.S.); Childhood; Chronic Disease; Clinical; Computers; Counseling; Coupled; Data; Development; Devices; Directly Observed Therapy; Education; Effectiveness; Elements; Emotions; Evaluation; Fatigue; Feedback; Focus Groups; Frequencies; Goals; Grant; HIV; HIV Infections; Health; Health Personnel; Health education; Incentives; Individual; Internet; Intervention; Knowledge; Lead; Life; Life Style; Link; Measurement; Measures; Medical; Monitor; Morbidity - disease rate; Motivation; Nature; Outcome; Outcome Study; Parents; Patient Self-Report; Performance; Persons; Pharmaceutical Preparations; Phase; Play; Population; Prevention; Production; Program Development; Provider; Public Health; Randomized Controlled Trials; Recruitment Activity; Regimen; Reminder Systems; Research; Resistance; Resistance development; Resources; Role; Sampling; Self Care; Self Efficacy; Small Business Innovation Research Grant; Social support; Stream; Technology; Telephone; Testing; Text; Therapeutic; Time; Treatment Efficacy; Treatment Failure; Treatment outcome; United States; Video Games; Viral; Viral Load result; Virus; Work; Youth; animation; base; behavior change; cohort; cost; design; digital; disorder prevention; efficacy testing; evidence base; health literacy; improved; innovation; interest; medication compliance; mortality; multidisciplinary; novel therapeutics; phase 2 study; prototype; psychologic; public health relevance; randomized trial; research and development; software development; theories; transmission process; treatment adherence

DESCRIPTION (provided by applicant): This study will aim to assess the feasibility and acceptability of using state-of-the-art video game technology to increase adherence among HIV+ adolescents and young adults (AYA) ages 13- 24. Treatment fatigue and the desire for increasing independence among this particular population can lead to non-adherence, which can result in treatment-resistant HIV-a critical problem in the field of HIV care. AYA can be hard to reach with conventional health messaging, yet they respond to video games with a high level of engagement. The goal of this project is to harness this strong motivation to play games to improve medication adherence. Previous games for behavior change have shown positive results by using the compelling nature of gameplay to make health education entertaining and to shift attitudes and emotions about the illness and the treatment. This intervention includes all those elements, but goes beyond them with a new innovation which changes the way video games are used for adherence. The intended result is a novel therapeutic which serves as the basis for a marketable product and an effective, evidence-based behavioral intervention that increases adherence to treatment in HIV+ AYA. Our multidisciplinary team will recruit HIV+ AYA to assist in informing the development of prototype smartphone/Web video games. We will develop the intervention with repeated input from the target audience, as well as among their parents and healthcare providers, to increase acceptability. We will conduct feasibility testing and revisions to increase game performance and acceptability. We will pilot an intervention to assess the impact of the games on adherence measures among non-adherent HIV+ AYA over a 6-month period. We will assess the games' acceptability and impact on adherence as measured through biological outcomes such as CD4 count and viral load. We anticipate the results will demonstrate feasibility which will provide data to inform a Phase II study to test the efficacy of the game on increasing adherence through a larger randomized controlled trial as well as provide a more significant level of feedback on playability, art and animation styles, player engagement, and overall acceptability. Successful completion of these aims will demonstrate how this product might advance the effective implementation of an evidence-based behavioral intervention for HIV/AIDS treatment and care among HIV+ youth. The core technology could also be revised to be applied to other medical conditions.

描述（由申请人提供）：本研究旨在评估使用最先进的视频游戏技术来增加13- 24岁艾滋病毒阳性青少年和年轻人（AYA）依从性的可行性和可接受性。治疗疲劳和这一特定人群中增加独立性的愿望可能导致不依从性，这可能导致耐药HIV-HIV护理领域的一个关键问题。AYA可能很难用传统的健康信息来传达，但他们对视频游戏的反应却很高。这个项目的目标是利用这种强烈的动机来玩游戏，以提高药物依从性。以前的行为改变游戏已经显示出积极的结果，通过使用游戏的引人注目的性质，使健康教育娱乐和改变对疾病和治疗的态度和情绪。这种干预包括所有这些元素，但超越了他们的一个新的创新，改变了视频游戏用于坚持的方式。预期的结果是一种新型的治疗方法，作为可销售产品的基础，以及一种有效的、基于证据的行为干预措施，可增加HIV+ AYA患者对治疗的依从性。我们的多学科团队将招募HIV+ AYA，以协助开发智能手机/网络视频游戏原型。我们将通过目标受众以及他们的父母和医疗保健提供者的反复输入来开发干预措施，以提高可接受性。我们将进行可行性测试和修订，以提高游戏性能和可接受性。我们将试行一项干预措施，以评估游戏对非依从性HIV+ AYA患者依从性措施的影响，为期6个月。我们将评估游戏的可接受性和对坚持的影响，通过生物学结果，如CD 4计数和病毒载量来衡量。我们预计结果将证明可行性，这将为II期研究提供数据，以测试 通过一项更大规模的随机对照试验，评估了游戏在提高依从性方面的功效，并在可玩性、艺术和动画风格、玩家参与度和整体可接受性方面提供了更高水平的反馈。这些目标的成功实现将证明该产品如何能够促进在艾滋病毒阳性青年中有效实施基于证据的艾滋病毒/艾滋病治疗和护理行为干预。核心技术也可以修改，以应用于其他医疗条件。