2014 Biomineralization Gordon Research Conference & Gordon Research Seminar

2014年生物矿化戈登研究会议

• 批准号: 8773959
• 负责人: Marc D McKee
• 金额: $ 1.7万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8773959
• 关键词: Acceleration; Address; Anniversary; Bacteria; Biological; Biology; Biotechnology; Breathing; Carbonates; Chemistry; Computer Simulation; Dentistry; Desiccation; Development; Discipline; Disease; Elements; Embryo; Engineering; Environment; Equilibrium; Esthesia; Event; Evolution; Film; Food; Growth; Health; Homeostasis; Human; Institution; Invertebrates; Investigation; Ions; Knowledge; Laboratories; Labyrinth; Learning; Life; Locomotion; Marine Invertebrates; Mastication; Medicine; Minerals; Molecular; Nanotechnology; Optics; Organism; Participant; Pathologic; Peptides; Phytoplankton; Plants; Play; Process; Property; Proteins; Regulation; Research; Research Personnel; Role; Science; Scientist; Silicon Dioxide; Skeleton; Staging; Structure; Students; Thinking; Tissues; Tooth structure; Transgenic Mice; Vertebrates; Washington; analytical method; base; biomineralization; bone; design; inorganic phosphate; interest; interfacial; iron oxide; magnetic field; marine organism; meetings; mineralization; mouse model; next generation; novel; ocean currents; otoconia; public health relevance; skeletal; soft tissue; stem; symposium

DESCRIPTION (provided by applicant): The 2014 Biomineralization GRC is the 50th anniversary of this longstanding, highly rated GRC conference indicating a high level of excellence and enthusiasm over many years for this event. The biomineralization field is broad, with over 60 identified biominerals cutting across most phyla. This premier conference attracts the best and brightest scientists investigating biological regulation of mineralization in many diverse organisms. Indeed, hardening strategies invoking mineralization have many functions depending on the organism producing the biomineral, which for vertebrates includes i) skeletal support, locomotion, protection and serving as an ion reservoir in bones, ii) mastication of food by teeth, and iii) providing for sensation of balance and linear acceleration in human inner ear otoconia. In nonvertebrates, biomineralization functions to i) align bacteria within a magnetic field, ii) create bouyancy elements for phytoplankton in ocean currents, iii) provide mineral ion storage depots and protection in plants, iv) protect and provide optical functions in marine organisms, and v) protect embryos from bacterial invasion and dessication in eggshells. Many fundamental principles guiding biomineralization apply to all these organismal structures, and much can be learned from their collective investigation, which is one of the unique features of this meeting. New knowledge of the molecular determinants guiding biomineralization processes also leads to new bioinspired thinking for the rational engineering of functional materials based largely on hardening design strategies for nanomineral- containing organized structures, thin films and bulk materials. This GRC/GRS will explore the basic principles by which organisms synthesize, control and make use of minerals, as well as the potential applications of these, particularly as they relate to the creation of novel, biologically regulated mineralized materials. Sessions planned for this meeting are: Biomineral nucleation and growth, Intracellular biomineralization, Biominerals in marine invertebrates, Regulation of biomineralization in marine invertebrates, Protein/peptide regulation of biomineralization, Computational simulations of biomineralization, Transgenic mouse models for normal and pathologic biomineralization, and Mineralized material properties and bioinspired materials. The Keynote Session(Co-evolution of the geo- and biospheres) will have Robert Hazen as keynote speaker from the Carnegie Institution of Washington's Geophysical Laboratory giving a talk entitled "How minerals and life co- evolve." The inclusion of a trainee/early-stage investigator-based GRS immediately proceeding the GRC assures scientific and professional development for the next generation of researchers in the biomineralization field. The GRS participants all continue as GRC participants, thus providing essentially a full week of scientific exchange for the trainees/early-stage investigators.

描述（由申请人提供）：2014 年生物矿化 GRC 是这一历史悠久、评价很高的 GRC 会议的 50 周年，表明多年来对这一活动的高度卓越和热情。生物矿化领域非常广泛，已识别出 60 多种生物矿物质，涵盖大多数门类。这次重要的会议吸引了最优秀和最聪明的科学家，研究许多不同生物体中矿化的生物调节。事实上，矿化的硬化策略具有许多功能，具体取决于产生生物矿物质的生物体，对于脊椎动物来说，这些功能包括 i) 骨骼支撑、运动、保护和充当骨骼中的离子库，ii) 通过牙齿咀嚼食物，以及 iii) 为人类内耳耳石提供平衡感和线性加速感。在非脊椎动物中，生物矿化的功能是：i) 在磁场内排列细菌，ii) 为洋流中的浮游植物产生浮力元件，iii) 为植物提供矿物离子储存库和保护，iv) 保护海洋生物并提供光学功能，v) 保护胚胎免受细菌入侵和蛋壳干燥。许多指导生物矿化的基本原则适用于所有这些有机结构，并且可以从它们的集体研究中学到很多东西，这是本次会议的独特之处之一。指导生物矿化过程的分子决定因素的新知识也引发了功能材料合理工程的新生物启发思维，该思维主要基于含纳米矿物质的组织结构、薄膜和块体材料的硬化设计策略。该 GRC/GRS 将探讨生物体合成、控制和利用矿物质的基本原理，以及这些原理的潜在应用，特别是与创造新颖的、生物调节的矿物有关的应用。 矿化材料。本次会议计划的会议包括：生物矿物成核和生长、细胞内生物矿化、海洋无脊椎动物中的生物矿物、海洋无脊椎动物生物矿化的调节、生物矿化的蛋白质/肽调节、生物矿化的计算模拟、正常和病理生物矿化的转基因小鼠模型以及矿化材料特性和生物启发 材料。主题演讲（地球圈和生物圈的共同进化）将邀请来自华盛顿卡内基研究所地球物理实验室的罗伯特·哈森（Robert Hazen）作为主讲人，发表题为“矿物与生命如何共同进化”的演讲。在 GRC 中立即纳入基于实习生/早期研究员的 GRS，可确保生物矿化领域下一代研究人员的科学和专业发展。 GRS 参与者都将继续作为 GRC 参与者，从而为受训者/早期研究人员提供基本上一整周的科学交流。