High resolution imaging of the myocardium

描述(由申请人提供)：有许多心脏疾病和治疗方法可以从高分辨率、实时成像模式提供的信息中受益。心肌的疾病和异常是由于心肌的问题，从感染到传导、结构和收缩的异常。在这些情况下，在没有直接看到心壁的情况下，将导管插入心腔，以获得电学测量，进行活检以检测细胞变化，或传递能量来治疗心律失常。我们的目标是开发心肌成像工具，为心脏电生理学家、心脏病专家和心脏外科医生提供心壁的视图，以帮助疾病诊断和指导治疗。我们的目标是开发高分辨率光学成像设备和图像分析，用于心壁疾病的诊断和治疗监测。光学成像在心肌中的应用范围从通过光学活检评估移植排斥反应到监测射频消融治疗。这份DP2新创新者提案专注于建立一个平台成像模式，包括设计光学导管和开发分类算法，用于心血管和心脏电生理实验室的心肌实时成像。我们的目标是证明OCT可以通过提供细胞水平的心肌成像来满足未满足的心脏成像的临床需求。我们的方法是多尺度的，包括：开发针对心肌成像优化的具有和不具有偏振敏感性的高分辨率OCT系统，以及用于执行光学活组织检查和提供心肌基质的三维成像的高分辨率导管的原型。我们将评估在有无血液存在的情况下体外培养人心肌组织的新技术。

DESCRIPTION (provided by applicant): There are a large range of diseases and therapies of the heart that can benefit from the information provided by a high-resolution, real time imaging modality. Diseases and abnormalities of the myocardium are due to problems of the heart muscle, ranging from infections to abnormalities in conduction, structure, and contraction. For these conditions, catheters are inserted into the heart chambers, without a direct view of the heart wall to obtain electrical measurements, take biopsies to detect cellular changes, or delivery energy to treat arrhythmias. It is our goal to develop tools for imaging the myocardium, which will provide cardiac electrophysiologist, cardiologist, and heart surgeons a view of the heart wall to aid in disease diagnosis and guide therapy. Our objective is to develop high-resolution optical imaging modalities and image analysis for diagnosis and therapy monitoring of diseases of the heart wall. Applications of optical imaging in the myocardium range from assessment of transplant rejection by preforming an optical biopsy to monitoring radiofrequency ablation therapy. This DP2 New Innovator proposal focuses on establishing a platform imaging modality including designing optical catheters and developing classification algorithms for real time imaging of the myocardium in the cardiovascular and cardiac electrophysiology laboratory. We aim to demonstrate that OCT can address unmet clinical needs of cardiac imaging by providing cellular-level imaging of the myocardium. Our approach is multi-scaled including: developing high resolution OCT system with and without polarization sensitivity optimized for myocardial imaging, and prototyping high resolution catheters to perform optical biopsy and provide three dimensional imaging of myocardial substrates. We will evaluate the new technology developed on human myocardial tissue ex vivo with and without the presence of blood.