High resolution imaging of the myocardium

高分辨率心肌成像

• 批准号: 8758262
• 负责人: Christine P Hendon
• 金额: $ 240万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-30 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8758262
• 关键词: Address; Algorithms; Arrhythmia; Biopsy; Blood; Cardiac; Cardiovascular system; Catheters; Classification; Clinical; Diagnosis; Disease; Electrophysiology (science); Goals; Graft Rejection; Heart; Heart Diseases; Human; Image; Image Analysis; Imaging Device; Infection; Laboratories; Monitor; Myocardial; Myocardial tissue; Myocardium; Optical Biopsy; Optics; Radiofrequency Interstitial Ablation; Resolution; Structure; Surgeon; System; Therapeutic Intervention; Time; Ventricular Remodeling; design; disease diagnosis; electrical measurement; imaging modality; insight; new technology; optical imaging; public health relevance

DESCRIPTION (provided by applicant): There are a large range of diseases and therapies of the heart that can benefit from the information provided by a high-resolution, real time imaging modality. Diseases and abnormalities of the myocardium are due to problems of the heart muscle, ranging from infections to abnormalities in conduction, structure, and contraction. For these conditions, catheters are inserted into the heart chambers, without a direct view of the heart wall to obtain electrical measurements, take biopsies to detect cellular changes, or delivery energy to treat arrhythmias. It is our goal to develop tools for imaging the myocardium, which will provide cardiac electrophysiologist, cardiologist, and heart surgeons a view of the heart wall to aid in disease diagnosis and guide therapy. Our objective is to develop high-resolution optical imaging modalities and image analysis for diagnosis and therapy monitoring of diseases of the heart wall. Applications of optical imaging in the myocardium range from assessment of transplant rejection by preforming an optical biopsy to monitoring radiofrequency ablation therapy. This DP2 New Innovator proposal focuses on establishing a platform imaging modality including designing optical catheters and developing classification algorithms for real time imaging of the myocardium in the cardiovascular and cardiac electrophysiology laboratory. We aim to demonstrate that OCT can address unmet clinical needs of cardiac imaging by providing cellular-level imaging of the myocardium. Our approach is multi-scaled including: developing high resolution OCT system with and without polarization sensitivity optimized for myocardial imaging, and prototyping high resolution catheters to perform optical biopsy and provide three dimensional imaging of myocardial substrates. We will evaluate the new technology developed on human myocardial tissue ex vivo with and without the presence of blood.

描述（由申请人提供）：有大量心脏疾病和治疗可受益于高分辨率、真实的时间成像模态提供的信息。心肌的疾病和异常是由于心肌的问题，从感染到传导、结构和收缩的异常。对于这些情况，将导管插入心脏腔室中，而不直接观察心脏壁以获得电测量，进行活检以检测细胞变化，或输送能量以治疗心律失常。我们的目标是开发心肌成像工具，这将为心脏电生理学家、心脏病专家和心脏外科医生提供心壁视图，以帮助疾病诊断和指导治疗。我们的目标是开发高分辨率的光学成像模式和图像分析，用于心脏壁疾病的诊断和治疗监测。光学成像在心肌中的应用范围从通过进行光学活检来评估移植排斥到监测射频消融治疗。该DP2 New Innovator提案侧重于建立平台成像模式，包括设计光学导管和开发分类算法，用于心血管和心脏电生理实验室中心肌的真实的实时成像。我们的目的是证明OCT可以通过提供心肌细胞水平成像来解决未满足的心脏成像临床需求。我们的方法是多尺度的，包括：开发高分辨率OCT系统，具有和不具有偏振灵敏度优化心肌成像，和原型高分辨率导管进行光学活检，并提供心肌基板的三维成像。我们将评估在有和没有血液存在的情况下对人体心肌组织进行离体培养的新技术。