Impact of mastitis in breast cancer formation

乳腺炎对乳腺癌形成的影响

• 批准号: 8653275
• 负责人: Minoti Hiremath
• 金额: $ 22.37万
• 依托单位: BOISE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8653275
• 关键词: Acute; Address; Affect; Applications Grants; Bacterial Infections; Biology; Biomedical Research; Breast; Breast Feeding; Calcium; Caring; Centers of Research Excellence; Chronic; Coculture Techniques; Development; Disease; Environment; Equipment; Extracellular Matrix; Funding; Future; Gene Proteins; Genes; Goals; Growth Factor; Histology; Housing; Incidence; Infection; Inflammation; Inflammatory; Injectable; Kidney; Lactation; Lobule; Mammary Gland Parenchyma; Mammary Tumorigenesis; Mammary gland; Mentors; Microscope; Milk; Modeling; Outcome; Pancreas; Pathology; Play; Pregnancy; Preparation; Process; Prophylactic treatment; Proteomics; Research; Research Personnel; Risk; Role; Sampling; Signal Transduction; Stem cells; System; Technical Expertise; Testing; Tissues; Tooth structure; Woman; Work; base; cancer risk; driving force; high throughput technology; improved; inflammatory breast cancer; instrumentation; malignant breast neoplasm; mass spectrometer; mastitis; mouse model; parathyroid hormone-related protein; research study; skeletal; therapeutic target; transcriptome sequencing; tumor progression

Mastitis is a common infection ofthe breast during lactation. Mastitis is either infective or due to milk stasis and induces inflammation in the extracellular matrix or stroma of the breast. Mastitis resolves with treatment but causes involution of mammary lobules. Episodes of mastitis are known to increase the risk of breast cancer. Moreover, in the post-lactation period, the breast cancer risk is increased, independent of mastitis. This is in part due to the induction of inflammatory genes during the process of involution. This project aims to determine if breast cancer develops more readily in a post-mastitis milieu. Using high-throughput technologies, we aim to define the acute and chronic changes that mastitis induces in the extracellular matrix (stroma) and how these changes contribute to the formation of breast cancer. Lastly, we aim to define the effects of mastitis on PTHrP signaling in the mammary stroma and PTHrP's role in promoting breast cancer via its effects on mammary stem cells. As a Junior Investigator in the COBRE in Matrix Biology, I will work with my scientific mentor to complete the scientific aims and to develop a grant proposal for future R01 funding.

乳腺炎是哺乳过程中乳腺癌的常见感染。乳腺炎是感染性的，要么是由于牛奶滞医，并引起细胞外基质或乳腺基质的炎症。乳腺炎通过治疗方法解决，但乳腺小叶的涉及。众所周知，乳腺炎发作会增加患乳腺癌的风险。此外，在分离后，乳腺癌的风险增加了，与乳腺炎无关。这部分是由于在交流过程中诱导炎症基因。该项目旨在确定乳腺癌是否在乳腺后的环境中更容易发展。使用高通量技术，我们旨在定义乳腺炎在细胞外基质（基质）中引起的急性和慢性变化，以及这些变化如何促进乳腺癌的形成。最后，我们旨在确定乳腺炎对乳腺基质中PTHRP信号传导的影响，并通过其对乳腺干细胞的影响来促进乳腺癌的作用。作为Matrix Biology的Cobre的初级研究员，我将与我的科学导师合作完成科学目标，并为未来R01资金制定赠款建议。