Neurocognitive Outcomes Following Proton Beam Radiation Therapy for Treatment of

质子束放射治疗后的神经认知结果

• 批准号: 8726734
• 负责人: LISA SCHUM KAHALLEY
• 金额: $ 14.87万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8726734
• 关键词: Address; Aftercare; Age; Appointment; Area; Attention; Brain Neoplasms; Cancer Center; Cancer Patient; Cancer Survivor; Child; Childhood; Childhood Brain Neoplasm; Clinical; Cognitive; Country; Cranial Irradiation; Data; Data Collection; Decision Making; Destinations; Diagnostic; Doctor of Philosophy; Dose; Environment; Excision; Exhibits; Family; Family Physicians; Fostering; Functional disorder; Funding; Growth; Impaired cognition; Intervention; K-Series Research Career Programs; Late Effects; Literature; Malignant Neoplasms; Medical; Medicine; Mentors; Modality; Neurocognitive; Neuropsychology; Operative Surgical Procedures; Outcome; Outcomes Research; Patients; Pediatric Oncology; Performance; Photons; Population; Psychology; Publishing; Quality of life; Radiation therapy; Reporting; Research; Research Methodology; Research Personnel; Research Training; Risk; Risk Factors; Severities; Short-Term Memory; Site; Staging; Survival Rate; Survivors; Techniques; Technology; Texas; Time; Tissues; Training; Writing; base; brain tissue; brain volume; cancer care; chemotherapy; clinical care; clinical risk; clinically significant; cognitive function; college; comparison group; cost; disorder control; experience; frontier; functional disability; functional outcomes; improved; interest; irradiation; longitudinal design; neuro-oncology; oncology program; patient oriented; pediatric department; processing speed; professor; programs; prospective; proton beam; proton therapy; social; statistics; survivorship; theories; therapy development; tumor

DESCRIPTION (provided by applicant): This candidate, Lisa Schum Kahalley, PhD, is an Assistant Professor in the Section of Psychology, Department of Pediatrics, at Baylor College of Medicine, with a secondary appointment in the Texas Children's Cancer Center. The proposed career development award outlines critical mentoring, training, and research experiences to prepare Dr. Kahalley for an independent research program in neurocognitive late effects research. The mentoring committee supporting this application consists of experienced researchers and clinicians in pediatric neuropsychology (Doug Ris, PhD), neuro-oncology (Fatih Okcu, MD, Murali Chintagumpala, MD), and longitudinal statistics (Paras Mehta, PhD). They will oversee this candidate's specialized training in neuropsychology, longitudinal research methods, and scientific writing and grantsmanship to prepare her to transition into neurocognitive outcome research and research independence. The proposed research plan will provide applied experience in these specific areas of focus. Brain tumor survivors are at risk for lasting treatment-related cognitive impairment. Interest in the use of proton beam radiation therapy (PBRT) for treatment of pediatric brain tumor continues to grow as many believe this technique could improve survival rates while also preserving quality of life outcomes. Many herald the clinical potential of PBRT to spare cognitive functioning by minimizing damage to healthy brain tissue without sacrificing disease control. Still, there are no published reports to date of cognitive outcomes following PBRT for pediatric brain tumor. This proposal includes two studies, one cross-sectional and one longitudinal, designed to maximize the empirical yield for this 5-year funding period. Study 1 is a prospective, longitudinal examination of neurocognitive outcomes and changes over time among patients treated for pediatric brain tumors with PBRT versus surgery alone. Study 2 is a cross-sectional comparison of neurocognitive outcomes between survivors of pediatric brain tumor previously treated with PBRT versus conventional radiation therapy. This proposal is consistent with NCI's strategic objectives to improve the quality of life for cancer survivors, promote safe and equitable cancer care, and foster informed decision making. Results will have clinical value, providing a timely initial report of neurocognitive functioning and comparison between treatment modalities that will be a notable addition to the sparse existent literature in PBRT late effects. Remarkable advantages of this research environment will facilitate the successful execution of these studies. In particular, Texas Children's Cancer Center has one of the largest pediatric neuro-oncology programs in the country with access to one of the few proton therapy centers in the US currently open for the treatment of pediatric brain tumor.

应聘者：丽莎·舒姆·卡哈利，博士，贝勒医学院儿科心理学系助理教授，德州儿童癌症中心副教授。拟议的职业发展奖概述了重要的指导、培训和研究经验，为Kahalley博士在神经认知迟发效应研究方面的独立研究计划做好准备。支持这一申请的指导委员会由儿科神经心理学(Doug Ris博士)、神经肿瘤学(Fatih Okcu医学博士)和纵向统计学(Paras Mehta博士博士)的经验丰富的研究人员和临床医生组成。他们将监督这位候选人在神经心理学、纵向研究方法、科学写作和勇气方面的专门培训，为她过渡到神经认知结果研究和研究独立性做好准备。拟议的研究计划将提供这些具体重点领域的应用经验。脑瘤幸存者面临与治疗相关的持久认知障碍的风险。人们对使用质子束放射治疗(PBRT)治疗儿童脑肿瘤的兴趣继续增长，因为许多人认为这种技术可以在提高存活率的同时保持生活质量。许多人预示着PBRT的临床潜力，它可以在不牺牲疾病控制的情况下，将对健康脑组织的损害降至最低，从而避免认知功能的损害。尽管如此，到目前为止还没有发表过关于儿童脑肿瘤PBRT后认知结果的报道。这项建议包括两项研究，一项是横向研究，另一项是纵向研究，旨在最大限度地提高5年期供资期间的经验收益。研究1是对接受PBRT和单纯手术治疗的儿童脑肿瘤患者的神经认知结果和随时间变化的前瞻性、纵向检查。研究2是对既往接受PBRT和常规放射治疗的儿童脑肿瘤幸存者的神经认知结果进行横断面比较。这一建议符合NCI的战略目标，即提高癌症幸存者的生活质量，促进安全和公平的癌症护理，并促进知情的决策。结果将具有临床价值，提供及时的神经认知功能的初步报告和治疗方式之间的比较，这将是对现有的为数不多的PBRT晚期效应文献的显著补充。这种研究环境的显著优势将促进这些研究的成功实施。特别是，德克萨斯儿童癌症中心拥有全国最大的儿科神经肿瘤学项目之一，可以进入美国目前开放的为数不多的治疗儿科脑瘤的质子治疗中心之一。