MRI & CT studies of the developing vocal tract

核磁共振成像

• 批准号: 8632679
• 负责人: HOURI Kaloustian VORPERIAN
• 金额: $ 64.37万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8632679
• 关键词: Accounting; Achievement; Acoustics; Address; Adult; Advocate; Age; Algorithms; Anatomy; Asses; Behavior; Birth; Cartilage; Child; Clinical; Consent; Data; Databases; Deglutition; Development; Discipline; Down Syndrome; Foundations; Genetic; Goals; Growth; Head and neck structure; Histocompatibility Testing; Hyoid bone structure; Image; Impairment; Individual; Intervention; Investigation; Joints; Larynx; Length; Longevity; Magnetic Resonance Imaging; Mandible; Measurement; Measures; Medical Imaging; Methods; Mission; Modeling; Morphology; Nature; Oral; Oropharyngeal; Output; Participant; Pattern; Pharyngeal structure; Physiology; Process; Production; Property; Relative (related person); Research; Respiration; Sampling; Secure; Shapes; Source; Specific qualifier value; Speech; Speech Acoustics; Speech Development; Speech Disorders; Speech Sound; Statistical Methods; Structure; System; Testing; Tissues; Width; Work; X-Ray Computed Tomography; acoustic imaging; base; clinical application; craniofacial; design; early childhood; feeding; improved; medical specialties; novel; postnatal; prenatal; public health relevance; sex; sexual dimorphism; soft tissue; sound; theories; three-dimensional modeling; trend; two-dimensional

The growth of the oral and pharyngeal structures and their respective cavities - that define the vocal tract (VT) - follow a prenatal to postnatal developmental continuum. Current theory asserts that postnatal growth of the VT is guided by the functions it serves, especially for the period from birth to early childhood where growth entails changes in size, shape, and relative proportions. Acoustic theory posits an evolving relationship between the VT anatomy and the properties of speech sounds during development. The available anatomic information is inadequate to explain the full nature of this relationship. Since 2000, our VT Development Lab has made steady progress towards its mission to quantitatively characterize sex-specific anatomic changes of the supralaryngeal speech system during development using a two-pronged anatomic-acoustic approach that entails: A. Anatomy: 1) Establishing a unique imaging database, consisting of 1679 imaging studies across the lifespan, that is representative of typically developing individuals of both sexes. 2) Compiling a large set of two dimensional landmark based measurements that capture the concurrent growth of the VT structures throughout the lifespan; and advancing novel analysis methods using select 3D models to quantify multidimensional growth (Chung et al. 2013, submitted) 3) Characterizing systematically the individual and relational growth of VT structures (Vorperian et al. 1999, 2005, 2007, 2009 & 2011). B. Acoustic: 1) Synthesizing findings on the development of vowel acoustic space i.e. the acoustic output of the developing VT (Vorperian & Kent, 2007). 2) Synthesizing findings on speech impairment in DS to help guide future research efforts (Kent & Vorperian, 2013). 3) Beginning to establish an acoustics database consisting of recordings from 250 participants including 90 individuals with Down Syndrome (DS) between the ages four to adulthood; and 4) Compiling developmental acoustics data including measures of the first four formants and their bandwidths. This proposed project combines imaging, acoustics, and VT modeling to study the development of the supra-laryngeal speech apparatus throughout the lifespan within the theoretical construct on function driven craniofacial growth. Research goals are to: 1) Capitalize on the imaging database to quantify the 3D growth of individual, relative and relational growth of VT structures while taking into account the structures' tissue type (bony, soft, cartilage and cavity), embryologic origin, plane of growth, and/or functional use. Also, extend our acoustics database while addressing fundamental issues in acoustic analysis. 2) Assess hypotheses that are acoustically driven and/or guided by structure/function interplay using typically and atypically developing individuals; and 3) Use age and sex-specific VT models to test hypotheses on anatomic-acoustic relationships. Project findings will provide a coherent and much needed picture on the development of VT structures throughout the lifespan. Such information is foundational for both theoretical constructs and clinical application in multiple disciplines that deal with craniofacial structures and functions.

口腔和咽部结构及其各自腔体的生长 - 定义了声道 (VT) - 遵循产前到产后的发育连续体。目前的理论认为，出生后的生长 VT 由其所服务的功能引导，特别是在从出生到幼儿期的生长过程中 包括尺寸、形状和相对比例的变化。声学理论假设了一种不断发展的关系 VT 解剖结构和发育过程中语音特性之间的关系。可用的解剖学 信息不足以解释这种关系的全部性质。自 2000 年以来，我们的 VT 开发实验室 在定量描述性别特异性解剖变化的使命方面取得了稳步进展 使用双管齐下的解剖声学方法开发过程中的喉上语音系统 需要： A. 解剖学： 1) 建立一个独特的影像数据库，包含 1679 项影像研究 寿命，代表正常发育的男女个体的寿命。 2）编译一大套两个 基于维度地标的测量，捕获 VT 结构的并发增长 整个生命周期；并使用选定的 3D 模型来量化推进新颖的分析方法 多维成长（Chung et al. 2013，提交）3）系统地描述个体和 VT 结构的相关增长（Vorperian 等人，1999、2005、2007、2009 和 2011）。 B. 声学：1) 综合元音声学空间发展的发现，即发展中的 VT 的声学输出 （Vorperian 和肯特，2007 年）。 2) 综合 DS 言语障碍的研究结果以帮助指导未来的研究 努力（Kent 和 Vorperian，2013）。 3) 开始建立一个由录音组成的声学数据库 250 名参与者，其中 90 名年龄在 4 岁到成年的唐氏综合症 (DS) 患者；和 4) 编译发育声学数据，包括前四个共振峰及其带宽的测量。 该项目结合了成像、声学和 VT 建模来研究 功能驱动的理论构建中喉上言语器官的整个生命周期 颅面生长。研究目标是： 1) 利用成像数据库来量化 3D 增长 VT 结构的个体、相对和关联生长，同时考虑结构的组织类型 （骨、软、软骨和空腔）、胚胎起源、生长平面和/或功能用途。另外，延长我们的 声学数据库，同时解决声学分析的基本问题。 2）评估假设 通过使用典型和非典型开发的结构/功能相互作用来声学驱动和/或引导 个人； 3) 使用年龄和性别特定的 VT 模型来检验解剖学-声学关系的假设。 项目研究结果将为 VT 结构的发展提供一个连贯且急需的图景 整个生命周期。这些信息是理论构建和临床应用的基础 在涉及颅面结构和功能的多个学科中。