Global Health Research and Training in malaria and cholera: opportunities for nov

疟疾和霍乱全球卫生研究和培训：十一月的机遇

• 批准号: 8679737
• 负责人: LINNIE GOLIGHTLY
• 金额: $ 17.21万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-15 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8679737
• 关键词: Award; Biological Assay; Biomedical Engineering; Bone Marrow; Cardiovascular Diseases; Cellular Phone; Cerebral Malaria; Cholera; Clinical; Clinical Trials; Collaborations; Data; Detection; Development; Devices; Diagnosis; Diagnostic; Disease; Dosage Forms; Educational process of instructing; Effectiveness; Engineering; Enteral; Evolution; Faculty; Feasibility Studies; Funding; Future; Generations; Ghana; Goals; Haiti; Human; Image; Immune response; Individual; Infection; International; Ischemia; Israel; Laboratories; Letters; Malaria; Mediating; Medical Students; Mentors; Mentorship; Modeling; Mus; National Institute of Allergy and Infectious Disease; Optics; Outcome; Parasites; Pathogenesis; Physicians; Plasmodium falciparum; Postdoctoral Fellow; Property; Rattus; Research; Research Project Grants; Research Training; Resources; Safety; Science; Scientist; Signal Transduction; Site; Staging; Stem cells; Stroke; Testing; Time; Toxicology; Training; Translational Research; United States National Institutes of Health; Universities; Work; base; bench to bedside; career; cellular engineering; clinical efficacy; commensal microbes; cost; engineering design; experience; global health; imaging probe; in vivo; innovation; meetings; member; multidisciplinary; novel; novel diagnostics; novel therapeutics; patient oriented research; pre-clinical; preclinical study; prevent; prophylactic; prototype; public health relevance; repaired; research clinical testing; research study; response; stem; stem cell biology

DESCRIPTION (provided by applicant): The goal of the current proposal is to provide mentorship for fellows, medical students and undergraduates for careers in global health through participation in patient-oriented research. The research will be conducted with firmly established collaborators at international sites of research excellence in Ghana and Haiti. The projects will stem from research funded by an NIH R01 and two Bill and Melinda Gates Grand Challenge Exploration Awards. These projects will provide experiences in highly innovative clinical translational research in transition from the bench to the bedside. The specific projects are: (1) Endothelial progenitor cells and the pathogenesis of cerebral malaria (2) Re-wiring enteric signaling for preventing cholera (3) A noninvasive cell phone imaging probe for diagnosing malaria. The collaborative research teams for these projects involve scientists from disparate fields such as stem cell biology and engineering working in concert with physician-scientists. The individuals are united in common goals of understanding basic mechanisms of malaria pathogenesis or the development of novel diagnostics and prophylactics for malaria and cholera, respectively. The experiences of trainees participating in these projects will prime them for futures in multidisciplinary collaborative global health research. Combined with complementary didactic studies they will be well prepared to make major advances in this field. In addition, the proposal will provide vital funding to permit me to continue to teach and train those in the global health "pipeline" for these types of careers.

描述（由申请人提供）：本提案的目标是通过参与以患者为导向的研究，为研究员、医科学生和本科生提供全球卫生事业的指导。这项研究将在加纳和海地的国际研究中心与稳固的合作者进行。这些项目将源于由NIH R01和两个比尔和梅林达盖茨大挑战探索奖资助的研究。这些项目将为高度创新的临床转化研究提供从实验室到床边的过渡经验。具体项目有：（1）内皮祖细胞与脑型疟疾的发病机制（2）肠道信号转导的重组预防霍乱（3）诊断疟疾的非侵入性手机成像探针。这些项目的合作研究团队包括来自不同领域的科学家，如干细胞生物学和工程学，与医生科学家合作。这些人团结在共同的目标上，即了解疟疾发病机制的基本机制，或分别开发疟疾和霍乱的新诊断和治疗方法。参加这些项目的受训人员的经验将为他们今后从事多学科合作全球卫生研究打下基础。与补充教学研究相结合，他们将做好充分准备，在这一领域取得重大进展。此外，该提案将提供重要的资金，使我能够继续为这些类型的职业教育和培训全球卫生“管道”中的人员。