Global Health Research and Training in malaria and cholera: opportunities for nov

描述（由申请人提供）：当前提案的目标是通过参与面向患者的研究，为研究员、医科学生和本科生在全球卫生领域的职业生涯提供指导。这项研究将在加纳和海地的国际卓越研究地点与牢固建立的合作者进行。这些项目将由美国国立卫生研究院R01和两个比尔和梅琳达·盖茨大挑战探索奖资助。这些项目将提供高度创新的临床转化研究经验，从实验台过渡到床边。具体项目有：(1)内皮祖细胞与脑型疟疾发病机制；(2)肠道信号重新接线预防霍乱；(3)无创手机成像探针诊断疟疾。这些项目的合作研究团队包括来自不同领域的科学家，如干细胞生物学和工程学，他们与内科科学家一起工作。这些人的共同目标是了解疟疾发病机制的基本机制，或开发疟疾和霍乱的新诊断和预防措施。学员参与这些项目的经验将为他们将来从事多学科全球卫生合作研究做好准备。结合互补性教学研究，他们将为在这一领域取得重大进展做好充分准备。此外，该提案将提供至关重要的资金，使我能够继续教授和培训那些在全球卫生“管道”中从事这类职业的人。

DESCRIPTION (provided by applicant): The goal of the current proposal is to provide mentorship for fellows, medical students and undergraduates for careers in global health through participation in patient-oriented research. The research will be conducted with firmly established collaborators at international sites of research excellence in Ghana and Haiti. The projects will stem from research funded by an NIH R01 and two Bill and Melinda Gates Grand Challenge Exploration Awards. These projects will provide experiences in highly innovative clinical translational research in transition from the bench to the bedside. The specific projects are: (1) Endothelial progenitor cells and the pathogenesis of cerebral malaria (2) Re-wiring enteric signaling for preventing cholera (3) A noninvasive cell phone imaging probe for diagnosing malaria. The collaborative research teams for these projects involve scientists from disparate fields such as stem cell biology and engineering working in concert with physician-scientists. The individuals are united in common goals of understanding basic mechanisms of malaria pathogenesis or the development of novel diagnostics and prophylactics for malaria and cholera, respectively. The experiences of trainees participating in these projects will prime them for futures in multidisciplinary collaborative global health research. Combined with complementary didactic studies they will be well prepared to make major advances in this field. In addition, the proposal will provide vital funding to permit me to continue to teach and train those in the global health "pipeline" for these types of careers.