Wake Forest NCORP Research Base

描述(由申请人提供)：维克森林NCORP癌症中心研究基地将继续利用已建立的和富有成效的维克森林癌症中心CCOP研究基地的独特资源和专业知识，并与我们的NCORP社区合作伙伴、顾问和其他研究基地建立已建立的合作关系，以解决癌症和治疗相关的症状和毒性、癌症护理提供问题以及与癌症相关的健康差距，如下所述。 具体目标1：扩大我们在以下领域的癌症控制临床试验活动：1)癌症治疗的心血管并发症，包括早期诊断、干预和预防策略；2)癌症治疗的神经认知并发症，重点是预防和早期治疗放化疗引起的神经认知影响，以及识别和治疗已有毒性的患者；3)更多的癌症和治疗相关症状和毒副作用，从诊断到长期生存。 具体目标2：与NCORP社区站点和其他NCORP研究基地合作，发展和加强我们的CCDR产品组合。我们将强调补充我们在心血管并发症和存活率方面已确立的专门知识领域的研究。 具体目标3：结合临床研究，通过生物标本采集和相关科学研究，阐明肿瘤发生的基本机制及治疗相关症状和毒性。这些努力将有助于更好地了解治疗结果和疗效，并确定具体干预措施对哪些人有效或无效。 具体目标4：在维克森林NCORP癌症中心研究基地进行的所有研究调查中，保持和加强我们在招募种族和少数民族以及服务不足的人群方面的成功。 具体目标5：通过参与和指导早期职业教师、医学肿瘤学和放射肿瘤学实习生、公共卫生博士后研究员和学生参与维克森林NCORP研究基地的活动，培训下一代医学和公共卫生研究人员。

Description (provided by the applicant): The Wake Forest NCORP Cancer Center Research Base will continue to utilize the unique resources and expertise of the established and productive Wake Forest Cancer Center CCOP Research Base and build on established collaborations with our NCORP community partners, consultants and other Research Bases to address cancer and treatment-related symptoms and toxicities, cancer care delivery issues, and cancer related health disparities as outlined below. Specific Aim 1: To expand our cancer control clinical trial activities in the following areas: 1) Cardiovascular complications of cancer therapy including early diagnosis, intervention and prevention strategies; 2) Neurocognitive complications of cancer therapy with an emphasis on prevention and early treatment of radiation and chemotherapy-induced neuro-cognitive effects, as well as identification and treatment of patients with established toxicity; and 3) Additional cancer and treatment-related symptoms and toxicities experienced across the spectrum from diagnosis through long-term survivorship. Specific Aim 2: To grow and strengthen our CCDR portfolio in conjunction with NCORP community sites and collaboration with other NCORP research bases. We will emphasize studies that complement our established thematic areas of expertise in cardiovascular complications and survivorship. Specific Aim 3: To elucidate the basic mechanisms underlying cancer and treatment-related symptoms and toxicities through bio specimen collection and correlative science accompanying our clinical investigations. These efforts will facilitate a better understanding of treatment outcomes and efficacy, and identification of individuals for whom specific interventions will or wil not be effective. Specific Aim 4: To maintain and build on our success in recruiting racial and ethnic minority and underserved populations across all research investigations pursued by the Wake Forest NCORP Cancer Center Research Base. Specific Aim 5: To train the next generation of medical and public health researchers through involvement and mentoring of early career faculty, medical oncology and radiation oncology trainees, and public health post-doctoral fellows and students in Wake Forest NCORP Research Base activities.