Center for Adaptive Leadership in Symptom Science

描述(由申请人提供)：拟议的卓越中心(P30)将促进生物行为研究，以扩展症状科学，使用适应性领导(AL)框架来概念化和研究慢性病中的认知/情感症状。该中心的总体目标是：(1)提高和维持从事跨学科生物行为研究的新护理科学家的生产力，以了解和改善症状、症状苦恼和症状后遗症，使用针对慢性病认知/情感改变的适应性方法；(2)协助研究人员量身定制研究方法和干预措施，通过解决少数群体健康问题并改进现有的或创建新的干预方案和自我报告措施(即患者报告结果测量信息系统[PROIS])，以优化认知/情感改变患者的研究参与。(3)提高研究人员使用纵向定量、定性和混合方法检查与认知/情感变化相关的症状、症状后遗症和患者适应轨迹的能力。中心的工作将在三个核心中进行，即行政核心、指导和学术核心以及设计和方法核心。该中心的预期成果包括对认知/情感症状和症状后遗症的轨迹进行研究，以描述模式、变异性和随时间的变化，以获得关于干预时机选择的关键期或过渡点所需的知识，确定亚人群(如认知能力水平不同的人或少数族裔的健康需求)之间的差异，并为开发/测试干预措施生成知识，以增强患者的适应能力。

DESCRIPTION (provided by applicant): The proposed Center of Excellence (P30) will promote biobehavioral research to extend symptom science using the Adaptive Leadership (AL) framework to conceptualize and study cognitive/affective symptoms in chronic illness. The overall Center aims are to: (1) Enhance and sustain the productivity of new nursing scientists engaged in interdisciplinary biobehavioral research to understand and ameliorate symptoms, symptom distress, and symptom sequelae using adaptive approaches for people with cognitive/affective changes in chronic illness; (2) Assist investigators to tailor research approaches and interventions to optimize research participation by people with cognitive/affective changes by addressing minority health issues and refining existing, or creating new intervention protocols and self-report measures (i.e., Patient-Reported Outcomes Measurement Information System [PROMIS]. (3) Increase investigator competence in using longitudinal quantitative, qualitative, and mixed method approaches to examine the trajectories of symptoms, symptom sequelae and patient adaptation associated with cognitive/affective changes. The work of the Center will be carried by in three Cores, the Administrative Core, the Mentoring and Scholarship Core, and the Design and Methods Core. Expected outcomes of the center include studies of trajectories of cognitive/affective symptoms and symptom sequelae to describe patterns, variability, and change over time to gain knowledge needed about critical periods or transition points for timing of interventions, identify differences within subpopulatios such as those with varying levels of cognitive ability or minority health needs, and generate knowledge for developing/testing interventions to enhance patients' adaptive capabilities.