Risk of Parkinson Disease Associated with Solvent Exposures in Finland

芬兰与溶剂接触相关的帕金森病风险

• 批准号: 8752056
• 负责人: Brad A Racette
• 金额: $ 22.21万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-25 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8752056
• 关键词: Age; Age of Onset; Aromatic Hydrocarbons; Benzene; Case-Control Studies; Censuses; Chlorinated Hydrocarbons; Collaborations; Comorbidity; Comprehensive Health Care; Coronary heart disease; Country; Data; Databases; Dementia; Disease; Disease Progression; Elderly; Emergency Situation; Environmental Air Pollutants; Epidemiologic Studies; Evaluation; Exposure to; Finland; Healthcare; Hip Fractures; Hydrocarbons; Immigration; Individual; Institutes; Institution; Link; Malignant Neoplasms; Mechanics; Mental Depression; Metals; Methylene Chloride; Morbidity - disease rate; Neurodegenerative Disorders; Neurologist; Occupational; Occupational Epidemiology; Occupational Exposure; Occupational Health; Occupations; Onset of illness; Organic solvent product; Parkinson Disease; Parkinsonian Disorders; Pensions; Persons; Pharmacotherapy; Phenotype; Plastics; Population; Prevention; Psychotic Disorders; Public Health; Public Policy; Records; Registries; Relative Risks; Research Personnel; Risk; Risk Factors; Solvents; Symptoms; Tetrachloroethylene; Toluene; Trichloroethanes; Trichloroethylene; Universities; Washington; Water Pollutants; Work; cohort; comparison group; compliance behavior; disease diagnosis; disorder risk; falls; migration; mortality; neuropsychiatry; neurotoxic; population based; population health; public health relevance; sex; treatment planning; urban area

DESCRIPTION (provided by applicant): Parkinson disease (PD) is a common disease of the elderly associated with substantial morbidity and early mortality. The causes of PD are largely unknown, but recent studies in small cohorts have implicated occupational exposure to neurotoxic solvents. Demonstrating a relation in a larger study would provide an opportunity to reduce exposures and hence disease risk. This is particularly important given the lack of any definitive pharmacotherapy to slow disease progression. Moreover, prevention would not be limited to workers with high exposures such as painters, mechanics, metal workers and plastic workers, since solvents are common environmental air and water pollutants in urban areas of the US. This proposal investigates the relation between occupational solvent exposure and incident PD in a large and efficiently-constructed, population-based study using existing data in Finland. Finland is an ideal country in which to conduct the studies described below due to low migration/immigration, universal health care, PD diagnoses made by neurologists, and high patient compliance with treatment plans. For this study, we will link the Finnish national population registry to the national comprehensive health care database to identify incident PD cases and a highly suitable comparison group, along with a wealth of covariate data for all subjects. We will further link these data with individual-level occupational data from the Finnish census and national pension database, and then estimate occupational solvent exposure, using the validated Finnish Job-Exposure Matrix (FINJEM). These Finnish databases have been used extensively to investigate occupational risk factors for many other diseases, including cancer and coronary heart disease, but remain to be used to investigate occupational risks associated with PD or other neurodegenerative diseases. The investigators and institutions in this proposal are ideally suited to perform the proposed study, representing the leading occupational health experts from the Finnish Institute of Occupational Health (FIOH) and well-established occupational epidemiology research collaboration between Washington University and the University of Washington.

描述(申请人提供)：帕金森病(PD)是一种常见的老年人疾病，具有相当高的发病率和早期死亡率。帕金森病的原因在很大程度上是未知的，但最近在小队列中进行的研究表明，职业暴露于神经毒性溶剂中。在一项更大规模的研究中证明两者之间的关系将提供一个机会，以减少暴露，从而减少疾病风险。这一点尤其重要，因为缺乏任何权威性的药物疗法来减缓疾病的进展。此外，预防措施将不仅限于油漆工、机械师、金属工人和塑料工人等高暴露工人，因为溶剂是美国城市地区常见的环境空气和水污染物。这项建议利用芬兰现有的数据，在一项大型、高效构建的、基于人群的研究中，调查了职业溶剂暴露与帕金森病事件之间的关系。芬兰是进行下述研究的理想国家，因为低移民/移民、全民医疗保健、神经科医生做出的帕金森病诊断以及患者对治疗计划的高度依从性。在这项研究中，我们将把芬兰国家人口登记与国家综合卫生保健数据库联系起来，以确定帕金森病事件病例和高度合适的对照组，以及所有受试者的大量协变量数据。我们将进一步将这些数据与芬兰人口普查和国家养老金数据库中的个人职业数据联系起来，然后使用经过验证的芬兰工作暴露矩阵(FINJEM)估计职业溶剂暴露。这些芬兰数据库被广泛用于调查许多其他疾病的职业风险因素，包括癌症和冠心病，但仍被用于调查与帕金森病或其他神经退行性疾病有关的职业风险。这项建议中的研究人员和机构非常适合执行拟议的研究，他们代表了芬兰职业健康研究所(FIOH)的领先职业健康专家，以及华盛顿大学和华盛顿大学之间久负盛名的职业流行病学研究合作。